UniProt: E1C3P6

Database: UniProt
Entry: E1C3P6_CHICK

LinkDB:  E1C3P6_CHICK 
Original site:  E1C3P6_CHICK

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Ontology (33)   
   GO (33)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (5)   
   RefSeq(pep) (5)   
Protein domain (15)   
   InterPro (7)   
   Pfam (2)   
   PROSITE (4)   
   SMART (2)   
All databases (59)   

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ID   E1C3P6_CHICK            Unreviewed;       544 AA.
AC   E1C3P6;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 98.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   Name=PAK1 {ECO:0000313|Ensembl:ENSGALP00010002842.1};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010002842.1, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00010002842.1}
RP   IDENTIFICATION.
RC   STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010002842.1};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; NP_001155844.1; NM_001162372.3.
DR   RefSeq; XP_015136339.1; XM_015280853.1.
DR   RefSeq; XP_015136340.1; XM_015280854.1.
DR   RefSeq; XP_015136341.1; XM_015280855.1.
DR   RefSeq; XP_015136342.1; XM_015280856.1.
DR   AlphaFoldDB; E1C3P6; -.
DR   SMR; E1C3P6; -.
DR   STRING; 9031.ENSGALP00000000961; -.
DR   PaxDb; 9031-ENSGALP00000000961; -.
DR   Ensembl; ENSGALT00010004716.1; ENSGALP00010002842.1; ENSGALG00010002102.1.
DR   GeneID; 419083; -.
DR   KEGG; gga:419083; -.
DR   CTD; 5058; -.
DR   VEuPathDB; HostDB:geneid_419083; -.
DR   GeneTree; ENSGT00950000182988; -.
DR   InParanoid; E1C3P6; -.
DR   OMA; KEGWISY; -.
DR   OrthoDB; 460351at2759; -.
DR   Reactome; R-GGA-202433; Generation of second messenger molecules.
DR   Reactome; R-GGA-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR   Reactome; R-GGA-2871796; FCERI mediated MAPK activation.
DR   Reactome; R-GGA-389359; CD28 dependent Vav1 pathway.
DR   Reactome; R-GGA-3928662; EPHB-mediated forward signaling.
DR   Reactome; R-GGA-3928664; Ephrin signaling.
DR   Reactome; R-GGA-399954; Sema3A PAK dependent Axon repulsion.
DR   Reactome; R-GGA-445144; Signal transduction by L1.
DR   Reactome; R-GGA-5218920; VEGFR2 mediated vascular permeability.
DR   Reactome; R-GGA-5621575; CD209 (DC-SIGN) signaling.
DR   Reactome; R-GGA-5627123; RHO GTPases activate PAKs.
DR   Reactome; R-GGA-5687128; MAPK6/MAPK4 signaling.
DR   Reactome; R-GGA-8964616; G beta:gamma signalling through CDC42.
DR   Reactome; R-GGA-9013149; RAC1 GTPase cycle.
DR   Reactome; R-GGA-9013404; RAC2 GTPase cycle.
DR   Reactome; R-GGA-9013406; RHOQ GTPase cycle.
DR   Reactome; R-GGA-9013407; RHOH GTPase cycle.
DR   Reactome; R-GGA-9013420; RHOU GTPase cycle.
DR   Reactome; R-GGA-9013423; RAC3 GTPase cycle.
DR   Reactome; R-GGA-9013424; RHOV GTPase cycle.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000000681; Expressed in cerebellum and 12 other cell types or tissues.
DR   GO; GO:0005884; C:actin filament; IEA:Ensembl.
DR   GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR   GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005518; F:collagen binding; IEA:Ensembl.
DR   GO; GO:0043015; F:gamma-tubulin binding; IEA:Ensembl.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR   GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Ensembl.
DR   GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR   GO; GO:0006338; P:chromatin remodeling; IEA:Ensembl.
DR   GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR   GO; GO:0048012; P:hepatocyte growth factor receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR   GO; GO:0060244; P:negative regulation of cell proliferation involved in contact inhibition; IEA:Ensembl.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0033148; P:positive regulation of intracellular estrogen receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0090063; P:positive regulation of microtubule nucleation; IEA:Ensembl.
DR   GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
DR   GO; GO:0051496; P:positive regulation of stress fiber assembly; IEA:Ensembl.
DR   GO; GO:1903608; P:protein localization to cytoplasmic stress granule; IEA:Ensembl.
DR   GO; GO:0032956; P:regulation of actin cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0050770; P:regulation of axonogenesis; IBA:GO_Central.
DR   GO; GO:0043408; P:regulation of MAPK cascade; IBA:GO_Central.
DR   GO; GO:0042060; P:wound healing; IEA:Ensembl.
DR   CDD; cd01093; CRIB_PAK_like; 1.
DR   CDD; cd06654; STKc_PAK1; 1.
DR   Gene3D; 3.90.810.10; CRIB domain; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR000095; CRIB_dom.
DR   InterPro; IPR036936; CRIB_dom_sf.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR033923; PAK_BD.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1.
DR   PANTHER; PTHR48015:SF20; SERINE_THREONINE-PROTEIN KINASE PAK 1; 1.
DR   Pfam; PF00786; PBD; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00285; PBD; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50108; CRIB; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   1: Evidence at protein level;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:E1C3P6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539}.
SQ   SEQUENCE   544 AA;  60649 MW;  CF359FD8AA5C1244 CRC64;
     MSNNGVETED KPPAPPMRNT STMIGSGSKD TGTLNHGSKP LPPNPEEKKK RDRFYRSILP
     GDKTNKKKEK ERPEISLPSD FEHTIHVGFD AVTGEFTGMP EQWARLLQTS NITKLEQKKN
     PQAVLDVLEF YNSKKTSSSQ KYMSFTDKLA EEYNSSNTLN VKAVSETPAV PSVSEDEDDE
     DDAAPPPVIA PRPEHTKSIY TRSVIDPLPP PTRDVATSPI SSPSENSTAA PDMLIRNAEK
     QKKKPKMSDE EILEKLRSIV SVGDPKKKYT RFEKIGQGAS GTVYTAMDVA TGQEVAIKQM
     NLQQQPKKEL IINEILVMRE NKNPNIVNYL DSYLVGEELW VVMEYLAGGS LTDVVTETCM
     DEGQIAAVCR ECLQALEFLH SNQVIHRDIK SDNILLGMDG SVKLTDFGFC AQITPEQSKR
     STMVGTPYWM APEVVTRKAY GPKVDIWSLG IMAIEMIEGE PPYLNENPLR ALYLIATNGT
     PELQNPEKLS PIFRDFLNRC LEMDVEKRGS AKELLQHQFL KIAKPLSSLT PLIIAAKEAT
     KNNH
//

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