ID E1C3P6_CHICK Unreviewed; 544 AA.
AC E1C3P6;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=PAK1 {ECO:0000313|Ensembl:ENSGALP00010002842.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010002842.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010002842.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010002842.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; NP_001155844.1; NM_001162372.3.
DR RefSeq; XP_015136339.1; XM_015280853.1.
DR RefSeq; XP_015136340.1; XM_015280854.1.
DR RefSeq; XP_015136341.1; XM_015280855.1.
DR RefSeq; XP_015136342.1; XM_015280856.1.
DR AlphaFoldDB; E1C3P6; -.
DR SMR; E1C3P6; -.
DR STRING; 9031.ENSGALP00000000961; -.
DR PaxDb; 9031-ENSGALP00000000961; -.
DR Ensembl; ENSGALT00010004716.1; ENSGALP00010002842.1; ENSGALG00010002102.1.
DR GeneID; 419083; -.
DR KEGG; gga:419083; -.
DR CTD; 5058; -.
DR VEuPathDB; HostDB:geneid_419083; -.
DR GeneTree; ENSGT00950000182988; -.
DR InParanoid; E1C3P6; -.
DR OMA; KEGWISY; -.
DR OrthoDB; 460351at2759; -.
DR Reactome; R-GGA-202433; Generation of second messenger molecules.
DR Reactome; R-GGA-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR Reactome; R-GGA-2871796; FCERI mediated MAPK activation.
DR Reactome; R-GGA-389359; CD28 dependent Vav1 pathway.
DR Reactome; R-GGA-3928662; EPHB-mediated forward signaling.
DR Reactome; R-GGA-3928664; Ephrin signaling.
DR Reactome; R-GGA-399954; Sema3A PAK dependent Axon repulsion.
DR Reactome; R-GGA-445144; Signal transduction by L1.
DR Reactome; R-GGA-5218920; VEGFR2 mediated vascular permeability.
DR Reactome; R-GGA-5621575; CD209 (DC-SIGN) signaling.
DR Reactome; R-GGA-5627123; RHO GTPases activate PAKs.
DR Reactome; R-GGA-5687128; MAPK6/MAPK4 signaling.
DR Reactome; R-GGA-8964616; G beta:gamma signalling through CDC42.
DR Reactome; R-GGA-9013149; RAC1 GTPase cycle.
DR Reactome; R-GGA-9013404; RAC2 GTPase cycle.
DR Reactome; R-GGA-9013406; RHOQ GTPase cycle.
DR Reactome; R-GGA-9013407; RHOH GTPase cycle.
DR Reactome; R-GGA-9013420; RHOU GTPase cycle.
DR Reactome; R-GGA-9013423; RAC3 GTPase cycle.
DR Reactome; R-GGA-9013424; RHOV GTPase cycle.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000000681; Expressed in cerebellum and 12 other cell types or tissues.
DR GO; GO:0005884; C:actin filament; IEA:Ensembl.
DR GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0001726; C:ruffle; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005518; F:collagen binding; IEA:Ensembl.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:Ensembl.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Ensembl.
DR GO; GO:0016477; P:cell migration; IEA:Ensembl.
DR GO; GO:0006338; P:chromatin remodeling; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:0048012; P:hepatocyte growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
DR GO; GO:0060244; P:negative regulation of cell proliferation involved in contact inhibition; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0033148; P:positive regulation of intracellular estrogen receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0090063; P:positive regulation of microtubule nucleation; IEA:Ensembl.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
DR GO; GO:0051496; P:positive regulation of stress fiber assembly; IEA:Ensembl.
DR GO; GO:1903608; P:protein localization to cytoplasmic stress granule; IEA:Ensembl.
DR GO; GO:0032956; P:regulation of actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0050770; P:regulation of axonogenesis; IBA:GO_Central.
DR GO; GO:0043408; P:regulation of MAPK cascade; IBA:GO_Central.
DR GO; GO:0042060; P:wound healing; IEA:Ensembl.
DR CDD; cd01093; CRIB_PAK_like; 1.
DR CDD; cd06654; STKc_PAK1; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR033923; PAK_BD.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1.
DR PANTHER; PTHR48015:SF20; SERINE_THREONINE-PROTEIN KINASE PAK 1; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00285; PBD; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|PeptideAtlas:E1C3P6};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539}.
SQ SEQUENCE 544 AA; 60649 MW; CF359FD8AA5C1244 CRC64;
MSNNGVETED KPPAPPMRNT STMIGSGSKD TGTLNHGSKP LPPNPEEKKK RDRFYRSILP
GDKTNKKKEK ERPEISLPSD FEHTIHVGFD AVTGEFTGMP EQWARLLQTS NITKLEQKKN
PQAVLDVLEF YNSKKTSSSQ KYMSFTDKLA EEYNSSNTLN VKAVSETPAV PSVSEDEDDE
DDAAPPPVIA PRPEHTKSIY TRSVIDPLPP PTRDVATSPI SSPSENSTAA PDMLIRNAEK
QKKKPKMSDE EILEKLRSIV SVGDPKKKYT RFEKIGQGAS GTVYTAMDVA TGQEVAIKQM
NLQQQPKKEL IINEILVMRE NKNPNIVNYL DSYLVGEELW VVMEYLAGGS LTDVVTETCM
DEGQIAAVCR ECLQALEFLH SNQVIHRDIK SDNILLGMDG SVKLTDFGFC AQITPEQSKR
STMVGTPYWM APEVVTRKAY GPKVDIWSLG IMAIEMIEGE PPYLNENPLR ALYLIATNGT
PELQNPEKLS PIFRDFLNRC LEMDVEKRGS AKELLQHQFL KIAKPLSSLT PLIIAAKEAT
KNNH
//