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Database: UniProt
Entry: E1C703_CHICK
LinkDB: E1C703_CHICK
Original site: E1C703_CHICK 
ID   E1C703_CHICK            Unreviewed;      2935 AA.
AC   E1C703;
DT   02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   02-DEC-2020, entry version 71.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGALP00000015880};
GN   Name=CENPF {ECO:0000313|Ensembl:ENSGALP00000015880};
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00000015880, ECO:0000313|Proteomes:UP000000539};
RN   [1] {ECO:0000313|Ensembl:ENSGALP00000015880, ECO:0000313|Proteomes:UP000000539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000015880,
RC   ECO:0000313|Proteomes:UP000000539};
RX   PubMed=15592404; DOI=10.1038/nature03154;
RG   International Chicken Genome Sequencing Consortium;
RA   Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA   Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA   Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA   Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA   McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA   Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA   Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA   Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA   Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA   Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA   Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA   Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA   Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA   Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA   Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA   Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA   Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA   Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA   Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA   Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA   Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA   Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA   Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA   Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA   Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA   Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA   Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA   Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA   Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA   Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA   Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA   Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA   Wilson R.K.;
RT   "Sequence and comparative analysis of the chicken genome provide unique
RT   perspectives on vertebrate evolution.";
RL   Nature 432:695-716(2004).
RN   [2] {ECO:0000313|Ensembl:ENSGALP00000015880}
RP   IDENTIFICATION.
RC   STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000015880};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
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DR   EMBL; AADN05000005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_989976.2; NM_204645.2.
DR   STRING; 9031.ENSGALP00000015880; -.
DR   PaxDb; E1C703; -.
DR   Ensembl; ENSGALT00000015897; ENSGALP00000015880; ENSGALG00000009690.
DR   GeneID; 395357; -.
DR   KEGG; gga:395357; -.
DR   CTD; 1063; -.
DR   eggNOG; ENOG502QVMD; Eukaryota.
DR   GeneTree; ENSGT00730000111187; -.
DR   HOGENOM; CLU_000551_0_0_1; -.
DR   InParanoid; E1C703; -.
DR   OMA; YNAQLVQ; -.
DR   OrthoDB; 205405at2759; -.
DR   TreeFam; TF101133; -.
DR   Reactome; R-GGA-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-GGA-2467813; Separation of Sister Chromatids.
DR   Reactome; R-GGA-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-GGA-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-GGA-9648025; EML4 and NUDC in mitotic spindle formation.
DR   Proteomes; UP000000539; Chromosome 3.
DR   Bgee; ENSGALG00000009690; Expressed in testis and 6 other tissues.
DR   ExpressionAtlas; E1C703; baseline and differential.
DR   GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR   GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR   GO; GO:0030496; C:midbody; IEA:Ensembl.
DR   GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR   GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0045120; C:pronucleus; IEA:Ensembl.
DR   GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR   GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR   GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR   GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR   GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0016202; P:regulation of striated muscle tissue development; IEA:Ensembl.
DR   GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 1.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 1.
DR   Pfam; PF10481; CENP-F_N; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000539}.
FT   DOMAIN          1..298
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          2128..2267
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2782..2827
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          212..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2713..2776
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2851..2935
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          13..85
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          97..138
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          162..189
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          271..443
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          472..541
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          544..606
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          621..704
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          709..736
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          891..935
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          957..1037
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1042..1065
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1164..1184
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1192..1240
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1281..1301
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1548..1568
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1580..1600
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1914..1934
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1964..2082
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2090..2222
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2234..2268
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2290..2376
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2397..2470
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2485..2541
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2553..2587
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2609..2639
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2650..2677
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        212..244
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2713..2732
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2733..2776
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2857..2904
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2905..2919
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2920..2935
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2935 AA;  339939 MW;  C8232767D5FAD7D2 CRC64;
     MSWAVEEWKE GLSPRVLQKI HELESQVDKL KKERQQRQFQ LESLEAALQK QKQKVENEKN
     ETAILKRENQ SLMELCDSLD KAKQKNSHDL QVKESQVNIL SGQLSSSKKE IERLEQELKR
     YKCELERSQQ SLIAAELSFS GTPQKSFTAP LTPVQSHNDA KFEELEEKYK KEVQERKKLE
     LELRTIQVKK INQPYLQQSS LSHREIARHQ ASSSVFSWQQ EKTPSRNQET PAKRTSSTPY
     FPWEKEGNSS IKSEKNKFDN SFSEDCNSLL INQLRAQNQE LNSTIKDLEQ QLQALEKEKK
     SHMNKYQETE LQLDRMKLEL TEKDKVLNKT RDKLTQMKTQ FDQATVQVQA MEQKMKRLSE
     ELNCQRQNAE SARQSLEQKI KAKEKEYQEE LSCQQRSLQK LDQQNSDVRN KLNQELQQAK
     NDFNALQAEL DKVIAVKQRL ERDTSDLTQK LCRAEQALLA AQAKETDLTR NFEDVKKEKN
     LLDAQYEKKL REIHQLEEEL GAVKQSLKQS QNFAEEMKNK NTSQEAELKL LEEKFIKQEN
     SLSLEKLKLA LADTEKQQRS TENLLKEKEN HIKEQNCKIS KMEEELEALQ RLLEFKQREC
     EELKKETNAF SQWRNENDHV INKLKLEKED MLIHIRDLES SLQSQQIENR EHSEKFKIME
     TERDRKNIEI KELRDMLGCK SAELEEQKKV CDELRQEAEC SDKKYCKDIE NMSCKILQLT
     NQVSELEEKI QLAASEGLQR EQYYHELLGE YEKICCLVKA KDTSEMTEDA EDYLQSGQDE
     TVLGNKQLAA NKPVAKGHGC TRALLGIEKM KDMMVLQDQI SFLEISPVAQ KQLNSDQQHQ
     DEDLPQIESE TEERLCDVEQ RHESFITETN QYISNLQADI SAHQKSIRKT VAIIEKKDMQ
     LQSLRERLEN QQTELQDLKT SNKFLEDSVR QLKLMSEMWG SEKKDMSSVI CSYSKEIEEL
     TGENATLKDL SRDLEQNQIT LLEANRNISN SLKEKEEIIS EMSRKHKEEK QCMEARTEEI
     SRELKVLQAQ YKLVEEENVN VMSILREQTV VFEEKKAELE QEEKLVLNEN KYILHKLIAS
     EEIKKNLIQE LQQLQSGFSD VERVPSPELD CLKQGMSNVK ATQNGIQEQH GTVCIQGREQ
     LVKELETKSE PLAYDFSCER KVCSDQLRKI MEEKDTELNK YQLNLELLHM DLEDREVSLE
     NYRLEVMQLK TDLKKMETEL EKSVREKETL QQELLSVKEL KASYSQLRLL SEDSQLEDND
     DDVSHNCGKR GMDEFVLSSS LQVITNKLSE LEKICERLQN ENTAFASPFK DSKTDGIRDI
     NKMAEEKENI INTNLRTEKA AFQDELLDQS DNSDLRMDCG NKEISFRFKE HSTGSSSDYE
     DLKLSSEEVK IYFAEIKDKF FSFQNEHMKL YEQHCSMVSK IMELQSCIKI LRAENSALSA
     SMSSVHLDSL RILLSSSQND TQSKLDETKS TDSLLDVTFS EVSKVDNSCN GGVCKWTDEI
     NQLKNSVEGM SEDAAKVLIE DDHSGHILDS VKELRSSTPS KYNPEGRIKE LEMLCQIYEK
     VIKVLQNQLH IQENMKTEEI QEMKNIMLSE RREIDKLQNL SDKKEWQQKL NYLTTEMECK
     LAEEGKTKNL SFDLKTASPQ LQVLNSGSLS LPCTDTENTT QKKNNTLYQL GVPVGNPALR
     KNKPKLIPVE KTAVGETAVH ENTTETTESK LVEAFSNKFH RGEECRNMSG KNTSSSHHDS
     ALSFSNSSIF LSSEDFFENE ISTETHQKEI KQKTIEDPKL IYAPEGHKNV DFLMEVKELN
     SQVDFQNAQL TLENSTLIEL EETAVEKEEN SGIKEKLESA SVSKQQLSCG VVSLGKEPEK
     ISAKHNVNKT VLSNTTDTLD DIELTKGNCH DLFLGAEIEQ RQTKSEQVNM ETHALFVEGN
     AEILQAKCQQ LERDREINLQ TIPSSLQEQL VSVTAERNHI GQEQSVLSEN KKELGQEYQK
     LQEKLKELET NKEDSAKTIR RLEREVKIQT NLLETAKSDT DQLSGEKDHL LQNLQSLEKD
     ALSFRLEEEK LQNQVADLNK EKEVLMRESE MMQSKLSALE IENSKLSRYL DGLITEKREL
     AARLNSAQKE VNQMREGMEK LKIKIESDER KKRHIAEKLK ENERKSDALL DKVERLEREL
     EMSEENLEDA VVQLETAKAE AETFITEKEE MAEKLKCLQS QIDDLTSQKE CLAKDSKEKQ
     ERILELESSN LTTAKLLEEK EEEKMQIKDE FENAVLLLKS ELKGMSEKLE FSSKEEEFAR
     AKEQVLINQV ACLEQDKTML LQECQELKNE NIKLDHTREL LAQEVVEYKQ KLEEKMQENH
     AFQQQIKETE ELSSQLTRME HEHECWHQEK QKLQNLIVEL NLKAQPFSDD GTFPDILNIL
     KVAYNDLEKE LESTLCEKTA LCKKVNEQTE NCIKLEVKLS DAEQAISKLQ EEFTMERKKL
     AEQIQLLQEH SEQNKIDLHL VVSEKHELTK SLGAVQKELQ EKENIMKREI SKYQDKLLQT
     EKEHQNALKE ANRKNEIQIE ACQEKVNSLE CFISSQKLEI EHLNSTKEEL NNSLKEANQT
     LGELLKLKAD NINTIVQLNK EKEFVQSEVQ LWIKSCKQME QEKEVLQKQL ADCEELLKKK
     DLSTDENAIT EEIKLELEEL QEAVEVKTRE ANENLEKYCS LIVKYYKLEE ANEMLKMQVT
     LLNGQLKQRT SDAVSSSLLN SGNSSTVSSQ SDKEMRWNED TTKPSTKRQR CEDTRKDNGE
     PRSPLPETSS KKKRKEDICQ NLENQENSDY EPDGLPEVVK RGFADIPTER VSPYILRRTT
     LNLWTSPHLA SQSENLPIPT QHVQTGRWDH LGEHSYSTPG GSKSQKINDE QQSQARTAFS
     PMKSSTRSPL WPYKQSTNIV SDNIRETHMI HKGKDSQNEQ ALPKQDQQQE NCKVQ
//
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