ID E1C857_CHICK Unreviewed; 252 AA.
AC E1C857;
DT 02-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2016, sequence version 3.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Tetraspanin {ECO:0000256|RuleBase:RU361218};
GN Name=TSPAN6 {ECO:0000313|Ensembl:ENSGALP00010023468.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|Ensembl:ENSGALP00010023468.1, ECO:0000313|Proteomes:UP000000539};
RN [1] {ECO:0000313|Ensembl:ENSGALP00010023468.1}
RP IDENTIFICATION.
RC STRAIN=broiler {ECO:0000313|Ensembl:ENSGALP00010023468.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361218}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361218}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC {ECO:0000256|ARBA:ARBA00006840, ECO:0000256|RuleBase:RU361218}.
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DR RefSeq; NP_001264532.1; NM_001277603.1.
DR AlphaFoldDB; E1C857; -.
DR STRING; 9031.ENSGALP00000010997; -.
DR PaxDb; 9031-ENSGALP00000010997; -.
DR Ensembl; ENSGALT00010040444.1; ENSGALP00010023468.1; ENSGALG00010016772.1.
DR GeneID; 422262; -.
DR KEGG; gga:422262; -.
DR CTD; 7105; -.
DR VEuPathDB; HostDB:geneid_422262; -.
DR GeneTree; ENSGT00940000159092; -.
DR InParanoid; E1C857; -.
DR OMA; FLFRHEI; -.
DR OrthoDB; 2913577at2759; -.
DR Proteomes; UP000000539; Chromosome 4.
DR Bgee; ENSGALG00000006808; Expressed in spermatocyte and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043124; P:negative regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0039532; P:negative regulation of cytoplasmic pattern recognition receptor signaling pathway; IEA:Ensembl.
DR CDD; cd03161; TM4SF2_6_like_LEL; 1.
DR Gene3D; 1.10.1450.10; Tetraspanin; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR InterPro; IPR048232; TSN6/7_LEL.
DR PANTHER; PTHR19282; TETRASPANIN; 1.
DR PANTHER; PTHR19282:SF426; TETRASPANIN-32; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR PRINTS; PR00259; TMFOUR.
DR SUPFAM; SSF48652; Tetraspanin; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 1: Evidence at protein level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361218};
KW Proteomics identification {ECO:0007829|PeptideAtlas:E1C857};
KW Reference proteome {ECO:0000313|Proteomes:UP000000539};
KW Transmembrane {ECO:0000256|RuleBase:RU361218};
KW Transmembrane helix {ECO:0000256|RuleBase:RU361218}.
FT TRANSMEM 21..42
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361218"
FT TRANSMEM 62..80
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361218"
FT TRANSMEM 92..114
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361218"
FT TRANSMEM 218..244
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361218"
SQ SEQUENCE 252 AA; 27828 MW; 462E8F64CA421764 CRC64;
MASPSRRLQT KPVITCLKSV LLTYTFVFWV SGIVLLAVGV WGRVSLAVYF SLLDEKATNV
PFVLVGAGVV VVLLGTFGCF ATCRGSTWML KLYAMLLSLI FLIVLVAAVV GFVFRHEIKT
NFESNLNLAL KNYNGTADHH SEAVDTIQRT LHCCGVQNYS DWEKTEYFTQ KGIPQSCCKS
QDDCSVEDLR DPSKAKQKVF VDGCFFLVTS AMESKMSVVA GISFGIACFQ LVGIILACCL
SQYITNNQYE MV
//