ID E1CHM2_XENTR Unreviewed; 456 AA.
AC E1CHM2;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Transcriptional coactivator YAP1 {ECO:0000313|RefSeq:NP_001182697.1};
DE SubName: Full=Yes-associated protein 1 {ECO:0000313|EMBL:BAJ19431.1, ECO:0000313|Ensembl:ENSXETP00000116602};
GN Name=yap1 {ECO:0000313|Ensembl:ENSXETP00000116602,
GN ECO:0000313|RefSeq:NP_001182697.1,
GN ECO:0000313|Xenbase:XB-GENE-952394};
GN Synonyms=xyap {ECO:0000313|RefSeq:NP_001182697.1}, yap
GN {ECO:0000313|RefSeq:NP_001182697.1}, Yap1
GN {ECO:0000313|EMBL:BAJ19431.1}, yap2
GN {ECO:0000313|RefSeq:NP_001182697.1}, yap65
GN {ECO:0000313|RefSeq:NP_001182697.1}, yki
GN {ECO:0000313|RefSeq:NP_001182697.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:BAJ19431.1};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000116602}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000116602};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|EMBL:BAJ19431.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Embryo {ECO:0000313|EMBL:BAJ19431.1};
RA Nejigane S., Haramoto Y., Okuno M., Asashima M., Takahashi S.;
RT "Yap1 and TAZ: Hippo signal transcriptional coactivators are expressed in
RT Xenopus early development.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001182697.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20979024;
RA Nejigane S., Haramoto Y., Okuno M., Takahashi S., Asashima M.;
RT "The transcriptional coactivators Yap and TAZ are expressed during early
RT Xenopus development.";
RL Int. J. Dev. Biol. 55:121-126(2011).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000116602}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2021) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001182697.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the YAP1 family.
CC {ECO:0000256|ARBA:ARBA00038057}.
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DR EMBL; AB551789; BAJ19431.1; -; mRNA.
DR RefSeq; NP_001182697.1; NM_001195768.1.
DR Ensembl; ENSXETT00000118092; ENSXETP00000116602; ENSXETG00000032689.
DR GeneID; 100488779; -.
DR KEGG; xtr:100488779; -.
DR AGR; Xenbase:XB-GENE-952394; -.
DR CTD; 10413; -.
DR Xenbase; XB-GENE-952394; yap1.
DR eggNOG; KOG0940; Eukaryota.
DR HOGENOM; CLU_041917_0_1_1; -.
DR OMA; LPMRMRN; -.
DR OrthoDB; 2593247at2759; -.
DR TreeFam; TF326941; -.
DR Proteomes; UP000008143; Chromosome 2.
DR Bgee; ENSXETG00000032689; Expressed in 4-cell stage embryo and 11 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 6.20.430.10; -; 1.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR17616:SF9; TRANSCRIPTIONAL COACTIVATOR YAP1; 1.
DR PANTHER; PTHR17616; YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER; 1.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS01159; WW_DOMAIN_1; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 137..170
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 195..228
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT REGION 60..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 456 AA; 49910 MW; ED32FE3D5016D603 CRC64;
MEPGSQPSAP AQPPPAGHQI VHVRSDSETD LEALFNAVMN PKNANVPQTL PMRMRKLPDS
FFKQPEPKSH SRQASTDGGS AGALTPQHVR AHSSPASLQL GAVSPGALSP PGVVPGPAPA
PNAQHLRQSS YEIPDDVPLP PGWEMAKTPS GQRYFLNHME QTTTWQDPRK AMLSQINLPA
PTSPPVQQNI MTPTGPLPDG WEQALTPEGE TYFINHKNKT TSWLDPRLDP RFAMNQQRLS
QSAPVKSPPA LPPQSPQSGV LGSGGNQQQM RLQQLQMEKE RLRLKHQELL RQVRPQELAL
RSQIPPMEQD GGTQNPVCST GISQEMRTMT MNSSDPFLNS GTYHSRDEST DSGLSMSSYS
VPRTPDDFLN SVDEMDTGEA ITQSTIPTQQ NRFPDYLETL PGTNVDLGTL EGEAMNVEGE
ELMPSLQEAL SSDILNDMES VLAATKLDKE SFLTWL
//
