ID E1EXF6_GIAIA Unreviewed; 370 AA.
AC E1EXF6;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=ribose-phosphate diphosphokinase {ECO:0000256|ARBA:ARBA00013247};
DE EC=2.7.6.1 {ECO:0000256|ARBA:ARBA00013247};
GN ORFNames=GLP15_409 {ECO:0000313|EMBL:EFO65110.1};
OS Giardia intestinalis (strain P15) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=658858 {ECO:0000313|EMBL:EFO65110.1, ECO:0000313|Proteomes:UP000008974};
RN [1] {ECO:0000313|EMBL:EFO65110.1, ECO:0000313|Proteomes:UP000008974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P15 {ECO:0000313|EMBL:EFO65110.1,
RC ECO:0000313|Proteomes:UP000008974};
RX PubMed=20929575; DOI=10.1186/1471-2164-11-543;
RA Jerlstrom-Hultqvist J., Franzen O., Ankarklev J., Xu F., Nohynkova E.,
RA Andersson J.O., Svard S.G., Andersson B.;
RT "Genome analysis and comparative genomics of a Giardia intestinalis
RT assemblage E isolate.";
RL BMC Genomics 11:543-543(2010).
CC -!- PATHWAY: Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose
CC 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from
CC D-ribose 5-phosphate (route I): step 1/1.
CC {ECO:0000256|ARBA:ARBA00004996}.
CC -!- SIMILARITY: Belongs to the ribose-phosphate pyrophosphokinase family.
CC {ECO:0000256|ARBA:ARBA00006478}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFO65110.1}.
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DR EMBL; ACVC01000047; EFO65110.1; -; Genomic_DNA.
DR AlphaFoldDB; E1EXF6; -.
DR STRING; 658858.E1EXF6; -.
DR EnsemblProtists; EFO65110; EFO65110; GLP15_409.
DR VEuPathDB; GiardiaDB:GLP15_409; -.
DR OMA; LLMGTHT; -.
DR OrthoDB; 276387at2759; -.
DR Proteomes; UP000008974; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0004749; F:ribose phosphate diphosphokinase activity; IEA:InterPro.
DR GO; GO:0009165; P:nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06223; PRTases_typeI; 1.
DR Gene3D; 3.40.50.2020; -; 2.
DR InterPro; IPR029099; Pribosyltran_N.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR InterPro; IPR005946; Rib-P_diPkinase.
DR NCBIfam; TIGR01251; ribP_PPkin; 1.
DR PANTHER; PTHR10210:SF32; RIBOSE-PHOSPHATE DIPHOSPHOKINASE; 1.
DR PANTHER; PTHR10210; RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER; 1.
DR Pfam; PF14572; Pribosyl_synth; 1.
DR Pfam; PF13793; Pribosyltran_N; 1.
DR SMART; SM01400; Pribosyltran_N; 1.
DR SUPFAM; SSF53271; PRTase-like; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:EFO65110.1};
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW Transferase {ECO:0000313|EMBL:EFO65110.1}.
FT DOMAIN 9..129
FT /note="Ribose-phosphate pyrophosphokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13793"
SQ SEQUENCE 370 AA; 40583 MW; D0703FB4D4871096 CRC64;
MSDKRKLAIA YTTASEPLAR RIIKLIQPSY EYSVVITLNI KQFSDGEISL QYESNIRGCD
LFIVGAICPP RCNDNLMELL LAIDAAKRAS AAHVTAIIPY FGYARQDRKA ASRTPISAKL
VTDLLIASGV DRVVVQDIHA AQIQGFFPSS IPFDHIDGYL VFIQAIIDRF EEDIKNLIVV
SPDAGGATRC RNLATQLHAD IAIIDKRRVV ANMCDVMNVV GDVNGKICLL YDDIVDTARS
LTKAAQALKE KGAEQVFACA SHAVLSGEAT RKIKESCIDY ILFSDSIPLS PKQIEELGEK
LQIVSGDFMF ANCINCIHTD TSFGESIKSV KVLAEQKLSK ITKGYSSSDG VVVSREQSVD
LRRFDVGTKQ
//