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Database: UniProt
Entry: E1EXF6_GIAIA
LinkDB: E1EXF6_GIAIA
Original site: E1EXF6_GIAIA 
ID   E1EXF6_GIAIA            Unreviewed;       370 AA.
AC   E1EXF6;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   RecName: Full=ribose-phosphate diphosphokinase {ECO:0000256|ARBA:ARBA00013247};
DE            EC=2.7.6.1 {ECO:0000256|ARBA:ARBA00013247};
GN   ORFNames=GLP15_409 {ECO:0000313|EMBL:EFO65110.1};
OS   Giardia intestinalis (strain P15) (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=658858 {ECO:0000313|EMBL:EFO65110.1, ECO:0000313|Proteomes:UP000008974};
RN   [1] {ECO:0000313|EMBL:EFO65110.1, ECO:0000313|Proteomes:UP000008974}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P15 {ECO:0000313|EMBL:EFO65110.1,
RC   ECO:0000313|Proteomes:UP000008974};
RX   PubMed=20929575; DOI=10.1186/1471-2164-11-543;
RA   Jerlstrom-Hultqvist J., Franzen O., Ankarklev J., Xu F., Nohynkova E.,
RA   Andersson J.O., Svard S.G., Andersson B.;
RT   "Genome analysis and comparative genomics of a Giardia intestinalis
RT   assemblage E isolate.";
RL   BMC Genomics 11:543-543(2010).
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose
CC       1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from
CC       D-ribose 5-phosphate (route I): step 1/1.
CC       {ECO:0000256|ARBA:ARBA00004996}.
CC   -!- SIMILARITY: Belongs to the ribose-phosphate pyrophosphokinase family.
CC       {ECO:0000256|ARBA:ARBA00006478}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFO65110.1}.
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DR   EMBL; ACVC01000047; EFO65110.1; -; Genomic_DNA.
DR   AlphaFoldDB; E1EXF6; -.
DR   STRING; 658858.E1EXF6; -.
DR   EnsemblProtists; EFO65110; EFO65110; GLP15_409.
DR   VEuPathDB; GiardiaDB:GLP15_409; -.
DR   OMA; LLMGTHT; -.
DR   OrthoDB; 276387at2759; -.
DR   Proteomes; UP000008974; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0004749; F:ribose phosphate diphosphokinase activity; IEA:InterPro.
DR   GO; GO:0009165; P:nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 2.
DR   InterPro; IPR029099; Pribosyltran_N.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   InterPro; IPR005946; Rib-P_diPkinase.
DR   NCBIfam; TIGR01251; ribP_PPkin; 1.
DR   PANTHER; PTHR10210:SF32; RIBOSE-PHOSPHATE DIPHOSPHOKINASE; 1.
DR   PANTHER; PTHR10210; RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER; 1.
DR   Pfam; PF14572; Pribosyl_synth; 1.
DR   Pfam; PF13793; Pribosyltran_N; 1.
DR   SMART; SM01400; Pribosyltran_N; 1.
DR   SUPFAM; SSF53271; PRTase-like; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000313|EMBL:EFO65110.1};
KW   Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW   Transferase {ECO:0000313|EMBL:EFO65110.1}.
FT   DOMAIN          9..129
FT                   /note="Ribose-phosphate pyrophosphokinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13793"
SQ   SEQUENCE   370 AA;  40583 MW;  D0703FB4D4871096 CRC64;
     MSDKRKLAIA YTTASEPLAR RIIKLIQPSY EYSVVITLNI KQFSDGEISL QYESNIRGCD
     LFIVGAICPP RCNDNLMELL LAIDAAKRAS AAHVTAIIPY FGYARQDRKA ASRTPISAKL
     VTDLLIASGV DRVVVQDIHA AQIQGFFPSS IPFDHIDGYL VFIQAIIDRF EEDIKNLIVV
     SPDAGGATRC RNLATQLHAD IAIIDKRRVV ANMCDVMNVV GDVNGKICLL YDDIVDTARS
     LTKAAQALKE KGAEQVFACA SHAVLSGEAT RKIKESCIDY ILFSDSIPLS PKQIEELGEK
     LQIVSGDFMF ANCINCIHTD TSFGESIKSV KVLAEQKLSK ITKGYSSSDG VVVSREQSVD
     LRRFDVGTKQ
//
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