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Database: UniProt
Entry: E1EXP1_GIAIA
LinkDB: E1EXP1_GIAIA
Original site: E1EXP1_GIAIA 
ID   E1EXP1_GIAIA            Unreviewed;       754 AA.
AC   E1EXP1;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   08-MAY-2019, entry version 34.
DE   SubName: Full=Dicer {ECO:0000313|EMBL:EFO65028.1};
GN   ORFNames=GLP15_2572 {ECO:0000313|EMBL:EFO65028.1};
OS   Giardia intestinalis (strain P15) (Giardia lamblia).
OC   Eukaryota; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=658858 {ECO:0000313|EMBL:EFO65028.1, ECO:0000313|Proteomes:UP000008974};
RN   [1] {ECO:0000313|EMBL:EFO65028.1, ECO:0000313|Proteomes:UP000008974}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P15 {ECO:0000313|EMBL:EFO65028.1,
RC   ECO:0000313|Proteomes:UP000008974};
RX   PubMed=20929575; DOI=10.1186/1471-2164-11-543;
RA   Jerlstrom-Hultqvist J., Franzen O., Ankarklev J., Xu F., Nohynkova E.,
RA   Andersson J.O., Svard S.G., Andersson B.;
RT   "Genome analysis and comparative genomics of a Giardia intestinalis
RT   assemblage E isolate.";
RL   BMC Genomics 11:543-543(2010).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EFO65028.1}.
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DR   EMBL; ACVC01000052; EFO65028.1; -; Genomic_DNA.
DR   EnsemblProtists; EFO65028; EFO65028; GLP15_2572.
DR   OMA; WADMYEE; -.
DR   OrthoDB; 475946at2759; -.
DR   Proteomes; UP000008974; Unassembled WGS sequence.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd00593; RIBOc; 2.
DR   Gene3D; 1.10.1520.10; -; 2.
DR   InterPro; IPR041279; Dicer_N.
DR   InterPro; IPR003100; PAZ_dom.
DR   InterPro; IPR036085; PAZ_dom_sf.
DR   InterPro; IPR000999; RNase_III_dom.
DR   InterPro; IPR036389; RNase_III_sf.
DR   Pfam; PF17895; Dicer_N; 1.
DR   Pfam; PF02170; PAZ; 1.
DR   Pfam; PF00636; Ribonuclease_3; 2.
DR   SMART; SM00535; RIBOc; 2.
DR   SUPFAM; SSF101690; SSF101690; 1.
DR   SUPFAM; SSF69065; SSF69065; 2.
DR   PROSITE; PS50821; PAZ; 1.
DR   PROSITE; PS50142; RNASE_3_2; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008974};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008974};
KW   RNA-mediated gene silencing {ECO:0000256|SAAS:SAAS00703041}.
FT   DOMAIN      169    251       PAZ. {ECO:0000259|PROSITE:PS50821}.
FT   DOMAIN      328    418       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN      643    734       RNase III. {ECO:0000259|PROSITE:PS50142}.
SQ   SEQUENCE   754 AA;  83680 MW;  B51BEC2E61B77EBE CRC64;
     MDALGYCCTI VTNRGPTYWL LLLDTHLGIL PGFKISTGRG LPAAEVYFET GPKVSLSRTD
     ANIIAMYQAI LFQLLGPTFP ASWIKIGATM PYNEYTFPRF VPSPPQFATL AFLPLLSPTN
     PLELRALMVT AQLICNAKRL SDEYTDYSTL SISLRGRIVA TPEIGWSLYV VLGIDSTQTS
     FSYFTRADEP VTYTNYYATV RNIHLRAADL PLVAAIRLDD LGDHQIPVSG SWDALAPKLR
     FLPPELCLLL PDEFDLIKIQ ALRFLPEIAK HIYDIQNTIY ALDKRFPNCG RVGGERYFAI
     TVGLRLDQGR GRGLAGWRTP FGPFGVSHTN VFQRLELLGD AVLGFVVTAR LLCLFPNASV
     GTLVDLKMEL VRNETLNYLV QMLRLPQLAE FSGTLMAKSK TWADMYEELV GSVFTGPNGI
     YGCEEFLAKT LISPEHSKPI ESACPDAIIR ALERICTGEA EVHEFKSIVD YAYEQGIRVF
     CSLRVSTMFL ERLRDIPSED LPDWYQLGIQ FSHHLGLSES DHAASVVDIV THLARGLWLS
     SPGFRVEWQT DKSELACLPA VPVLYVYHRS VQYPILYGSL TGSPKGPIAS KILSLCEKFL
     AYRSSGGNIR MAAQAISTSL VIPIPSGTIP FLIQLLQLAL TPHVYQKLEL LGDAFLKCNL
     AFHLHVLHPT LTEGTLTRMR QSAETNCVLG KLIRRFPSIV DKVITESHPK IQSDSKVYGD
     TFEAILAAVL LACGEEAASS FVREFVLPQV VTDV
//
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