ID E1EZ74_GIAIA Unreviewed; 387 AA.
AC E1EZ74;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Nucleoside diphosphate kinase {ECO:0000313|EMBL:EFO64505.1};
GN ORFNames=GLP15_2014 {ECO:0000313|EMBL:EFO64505.1};
OS Giardia intestinalis (strain P15) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=658858 {ECO:0000313|EMBL:EFO64505.1, ECO:0000313|Proteomes:UP000008974};
RN [1] {ECO:0000313|EMBL:EFO64505.1, ECO:0000313|Proteomes:UP000008974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P15 {ECO:0000313|EMBL:EFO64505.1,
RC ECO:0000313|Proteomes:UP000008974};
RX PubMed=20929575; DOI=10.1186/1471-2164-11-543;
RA Jerlstrom-Hultqvist J., Franzen O., Ankarklev J., Xu F., Nohynkova E.,
RA Andersson J.O., Svard S.G., Andersson B.;
RT "Genome analysis and comparative genomics of a Giardia intestinalis
RT assemblage E isolate.";
RL BMC Genomics 11:543-543(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000256|ARBA:ARBA00004430}.
CC -!- SIMILARITY: Belongs to the NDK family. {ECO:0000256|RuleBase:RU004011}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFO64505.1}.
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DR EMBL; ACVC01000093; EFO64505.1; -; Genomic_DNA.
DR AlphaFoldDB; E1EZ74; -.
DR STRING; 658858.E1EZ74; -.
DR EnsemblProtists; EFO64505; EFO64505; GLP15_2014.
DR VEuPathDB; GiardiaDB:GLP15_2014; -.
DR OMA; VCMCLEI; -.
DR OrthoDB; 46345at2759; -.
DR Proteomes; UP000008974; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0004550; F:nucleoside diphosphate kinase activity; IEA:InterPro.
DR GO; GO:0006241; P:CTP biosynthetic process; IEA:InterPro.
DR GO; GO:0006183; P:GTP biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006228; P:UTP biosynthetic process; IEA:InterPro.
DR CDD; cd04412; NDPk7B; 1.
DR Gene3D; 3.30.70.141; Nucleoside diphosphate kinase-like domain; 2.
DR InterPro; IPR006602; DM10_dom.
DR InterPro; IPR034907; NDK-like_dom.
DR InterPro; IPR036850; NDK-like_dom_sf.
DR InterPro; IPR037993; NDPk7B.
DR InterPro; IPR001564; Nucleoside_diP_kinase.
DR PANTHER; PTHR46135; NME/NM23 FAMILY MEMBER 8; 1.
DR PANTHER; PTHR46135:SF3; THIOREDOXIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00334; NDK; 2.
DR PRINTS; PR01243; NUCDPKINASE.
DR SMART; SM00676; DM10; 1.
DR SMART; SM00562; NDK; 1.
DR SUPFAM; SSF54919; Nucleoside diphosphate kinase, NDK; 2.
DR PROSITE; PS51336; DM10; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000313|EMBL:EFO64505.1};
KW Transferase {ECO:0000313|EMBL:EFO64505.1}.
FT DOMAIN 2..90
FT /note="DM10"
FT /evidence="ECO:0000259|PROSITE:PS51336"
SQ SEQUENCE 387 AA; 43145 MW; 93E6992F384BCED4 CRC64;
MDTTRYSFNV LWYDRIADQD RPYILSYYPD TREIDMYEVA TKRVFLKKCQ YPEFNFADCH
VGGTITIYSR QLKIVGYAND FTCNALSAEK EATCAIVKPH AVAESPIIIA DAIISAMQRN
LRISRIRMVR FSENDVNAFY EEHIGKPFFP NLAAMVMAGP ACVIELIGPN AILAWRDIIG
PTDPSKCDPS KHLRGKYGVD VTSNAFHGSA SKGDADRELG IVFRLCPVAA IGCKNNSVML
IQPKFKDYVG HILVGLVNYI SKISPDIYIT GINTCIPTAN DLAEVMAAYQ GVIPRWSEYI
DVFSTGPCIA LEIATHRPPE EVNMIETLRA FAGPFEPKIA VYLAPESVRA VYGTDAINNC
VFVTDLPEEA ELHADFWFRI MPSAGKR
//
