ID E1EZK5_GIAIA Unreviewed; 534 AA.
AC E1EZK5;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Cysteine protease {ECO:0000313|EMBL:EFO64378.1};
DE Flags: Fragment;
GN ORFNames=GLP15_5239 {ECO:0000313|EMBL:EFO64378.1};
OS Giardia intestinalis (strain P15) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=658858 {ECO:0000313|EMBL:EFO64378.1, ECO:0000313|Proteomes:UP000008974};
RN [1] {ECO:0000313|EMBL:EFO64378.1, ECO:0000313|Proteomes:UP000008974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P15 {ECO:0000313|EMBL:EFO64378.1,
RC ECO:0000313|Proteomes:UP000008974};
RX PubMed=20929575; DOI=10.1186/1471-2164-11-543;
RA Jerlstrom-Hultqvist J., Franzen O., Ankarklev J., Xu F., Nohynkova E.,
RA Andersson J.O., Svard S.G., Andersson B.;
RT "Genome analysis and comparative genomics of a Giardia intestinalis
RT assemblage E isolate.";
RL BMC Genomics 11:543-543(2010).
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFO64378.1}.
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DR EMBL; ACVC01000097; EFO64378.1; -; Genomic_DNA.
DR AlphaFoldDB; E1EZK5; -.
DR STRING; 658858.E1EZK5; -.
DR EnsemblProtists; EFO64378; EFO64378; GLP15_5239.
DR VEuPathDB; GiardiaDB:GLP15_5239; -.
DR OMA; KCQDANI; -.
DR OrthoDB; 5473778at2759; -.
DR Proteomes; UP000008974; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF642; PRO-CATHEPSIN H; 1.
DR Pfam; PF00112; Peptidase_C1; 2.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:EFO64378.1};
KW Membrane {ECO:0000256|SAM:Phobius}; Protease {ECO:0000313|EMBL:EFO64378.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 489..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 66..424
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT REGION 24..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EFO64378.1"
SQ SEQUENCE 534 AA; 58681 MW; 25AA762A9338B8FD CRC64;
GAGTCTRDSK SNKYTNCNVD AYELGPDLKG ESNPSSQNAN DRSKKQDSFF LVDVRDMNVK
GRQRTLPHSV DLREVGLVTR AKDQGLCGSC YEFTTIEVLE NLMLVDADLY TRGKYLDPKP
FPSNYFCNCS TSAGQDDSKK SADCTTMITV QNRTEQDYTD IPENWKSYSA STLRLSVQFL
LDNLIGGNYC NGGNYFRAIS DFVNKLSKLA KESECIYREY ATPEKAAPDS GAKCQGTNIG
DFNPAFVSMP MKKKTSSSSA GAAGSDEYEY VTNGGSGTPN KFGVYQILRN EGVPASGLIV
EEMDKGKFAA WERNVMNVLA RGVGVAAAMH TESGVDTSID KDYESVVASA LTFNLYKSGV
FPDVKCVRSA TNHQVMLVGY GAYKGRPVWI LRNSWGTGWG VSGYYYIGRG SNSLCHELSV
EYTMPRFYGP DRDGVHPLFL SVPDEAQKVA LADAVRASPF SNKVKRCVNG LDTVDAYGGT
MCEAIEVSAW NYVLVGALAI VLFFLGRYCM QYYFCAPEYI FHSPINLNLP HKGV
//