ID   E1F0E1_GIAIA            Unreviewed;       767 AA.
AC   E1F0E1;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   22-FEB-2023, entry version 32.
DE   RecName: Full=DUF676 domain-containing protein {ECO:0000259|Pfam:PF05057};
GN   ORFNames=GLP15_3470 {ECO:0000313|EMBL:EFO64084.1};
OS   Giardia intestinalis (strain P15) (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=658858 {ECO:0000313|EMBL:EFO64084.1, ECO:0000313|Proteomes:UP000008974};
RN   [1] {ECO:0000313|EMBL:EFO64084.1, ECO:0000313|Proteomes:UP000008974}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P15 {ECO:0000313|EMBL:EFO64084.1,
RC   ECO:0000313|Proteomes:UP000008974};
RX   PubMed=20929575; DOI=10.1186/1471-2164-11-543;
RA   Jerlstrom-Hultqvist J., Franzen O., Ankarklev J., Xu F., Nohynkova E.,
RA   Andersson J.O., Svard S.G., Andersson B.;
RT   "Genome analysis and comparative genomics of a Giardia intestinalis
RT   assemblage E isolate.";
RL   BMC Genomics 11:543-543(2010).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFO64084.1}.
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DR   EMBL; ACVC01000105; EFO64084.1; -; Genomic_DNA.
DR   AlphaFoldDB; E1F0E1; -.
DR   ESTHER; giaia-e1f0e1; Duf_676.
DR   EnsemblProtists; EFO64084; EFO64084; GLP15_3470.
DR   VEuPathDB; GiardiaDB:GLP15_3470; -.
DR   OMA; YTELACQ; -.
DR   OrthoDB; 5476950at2759; -.
DR   Proteomes; UP000008974; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR007751; DUF676_lipase-like.
DR   InterPro; IPR044294; Lipase-like.
DR   PANTHER; PTHR12482:SF5; DUF676 DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR12482; UNCHARACTERIZED; 1.
DR   Pfam; PF05057; DUF676; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   4: Predicted;
FT   DOMAIN          520..648
FT                   /note="DUF676"
FT                   /evidence="ECO:0000259|Pfam:PF05057"
FT   REGION          218..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          385..414
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        222..257
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..414
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   767 AA;  85644 MW;  9D1C5600EBC36E4E CRC64;
     MSKEKSELNA YCLQVVVGSM FVGYNAPRGY YVLKVSVKDH RKIKYVAVSS IKSFLLPTQT
     KDCLTRYKVT TQIIGIEQTC YHSEPFYIHE GNQTIHFNTI LTFTVGSKNR QISCAVISFK
     LYYVPFPKDF DTVEKIINAD ESQYIKAFDQ SLFENPKLST VMKRRCYLDN FCVPFAGYHI
     ETFNVTDNFK LECFVSNFLT SEKTKLMIYD MNGVVSESTD LSDNSEDPRR VLSGKDDEED
     DDTGKKRETG RGGSERQLKK LLNKSRVEST DISQRYNSLK TILYDVCGCT IERDPILNSV
     VVSVDNVAVT PLNIAFVLKA ARSVYLKMLP SFRAQFYGYL TYQDLKSMFQ APDTHNDSYY
     TELACQYRKT IRSLYSPQTS MITSRVDDTI EDSDRSEQSS RASSRSASVS ASSGAVNPSY
     GNIPYKPTVS TSSAMPTKSE LLDIIMQNRK LYPYVRPEKY VIEAPIVFVR SYAQGSTPTD
     DKLTVASLEP PVANNVYYAV SSNVKSARKL LSTDLDKINV YIYLHGLQAQ HLDMLAISEC
     LATFRKGKSL DILCESYADS SAAPSKENAG KIYNEIFSKL SSRNVKLDSL QSINFIGHSL
     GGLLCLKVAS MLPPDQQEKL GFLLTINAPI TGTTFKSNLV SMAVPFITGK MPVIKEMKDC
     SSDGVIYTTA TQFPSFKQAY FVGTCGDGFV PFRCATGMGI TEDQVLISNL LAKNIKSSVV
     KQAIVCFDAG ELKENGSGLN NIIGRTAHLR LLEDRQAFRM VLEALGF
//