ID E1F2Q8_GIAIA Unreviewed; 645 AA.
AC E1F2Q8;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 49.
DE RecName: Full=cysteine--tRNA ligase {ECO:0000256|ARBA:ARBA00012832};
DE EC=6.1.1.16 {ECO:0000256|ARBA:ARBA00012832};
DE AltName: Full=Cysteinyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00031499};
GN ORFNames=GLP15_3124 {ECO:0000313|EMBL:EFO63218.1};
OS Giardia intestinalis (strain P15) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=658858 {ECO:0000313|EMBL:EFO63218.1, ECO:0000313|Proteomes:UP000008974};
RN [1] {ECO:0000313|EMBL:EFO63218.1, ECO:0000313|Proteomes:UP000008974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P15 {ECO:0000313|EMBL:EFO63218.1,
RC ECO:0000313|Proteomes:UP000008974};
RX PubMed=20929575; DOI=10.1186/1471-2164-11-543;
RA Jerlstrom-Hultqvist J., Franzen O., Ankarklev J., Xu F., Nohynkova E.,
RA Andersson J.O., Svard S.G., Andersson B.;
RT "Genome analysis and comparative genomics of a Giardia intestinalis
RT assemblage E isolate.";
RL BMC Genomics 11:543-543(2010).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFO63218.1}.
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DR EMBL; ACVC01000140; EFO63218.1; -; Genomic_DNA.
DR AlphaFoldDB; E1F2Q8; -.
DR STRING; 658858.E1F2Q8; -.
DR EnsemblProtists; EFO63218; EFO63218; GLP15_3124.
DR VEuPathDB; GiardiaDB:GLP15_3124; -.
DR OMA; FHNDMKS; -.
DR OrthoDB; 2140072at2759; -.
DR Proteomes; UP000008974; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004817; F:cysteine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006423; P:cysteinyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00672; CysRS_core; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR015803; Cys-tRNA-ligase.
DR InterPro; IPR024909; Cys-tRNA/MSH_ligase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR032678; tRNA-synt_1_cat_dom.
DR NCBIfam; TIGR00435; cysS; 1.
DR PANTHER; PTHR10890:SF3; CYSTEINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR PANTHER; PTHR10890; CYSTEINYL-TRNA SYNTHETASE; 1.
DR Pfam; PF01406; tRNA-synt_1e; 1.
DR PRINTS; PR00983; TRNASYNTHCYS.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 4: Predicted;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000313|EMBL:EFO63218.1}; ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT DOMAIN 26..351
FT /note="tRNA synthetases class I catalytic"
FT /evidence="ECO:0000259|Pfam:PF01406"
SQ SEQUENCE 645 AA; 73022 MW; 8970D60EE0EB0FFA CRC64;
MAAFPTSVWI TNSLTGRLEE LRTRAPSTVL AYICGPTVYD STHLGHARTY VTFDVIRRIF
EDYFGLRVHY QCNITDVDDK IIARAVERGS SIFDVCRKYE QEFFSDMRTL SVRPFTVVTR
VTEYMADIIL FIQKIMDNGF AYVSAGSVYF DVVVARNAGY SYPKLRPLGS SSDELQLLIQ
NADGVDSKNR VSEKRSSSDF ALWKAWKETE PEDAKWDATF SRKNGAVSEL ITLPGRPGWH
IECSAMAAAA LGKNTEGAFD LHLGGCDLQF PHHDNELIQL ETWAKKKNMI GCFLHSGHLK
IAGDVMSKSK KNFKTVREVL NIFTANQVRM LFCMVPYSAS LDYSISMMDA AVAKDKKITS
FLSNCRQIIQ HEEELSEPIK NLRYNTMEET LEAQTIEFLS NVDIAFRNDI SIVSAMNHIM
SLIDNCKAYI FACQTEGRQV NTFLLSNARD KIVHILSIMG FSYAGSENSA TGNALQIARV
VCNFRREIKD LLMAPTINTV EADVKALRKA LLGLCDKLRD QDLPLTGFAI EDADKESCVK
PINVGEWKIQ RQRELDLAEA KRLQQEKVQQ EKLEKQRLER AKALIPAEKM FLENAEFSAF
DEHGIPTHLA ETGPDGNPVP IPKSRYKKLR KDWEAQKKLN EKYSN
//