ID E1F2U0_GIAIA Unreviewed; 487 AA.
AC E1F2U0;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=DNA-directed RNA polymerase III subunit RPC3 {ECO:0000256|RuleBase:RU367076};
DE Short=RNA polymerase III subunit C3 {ECO:0000256|RuleBase:RU367076};
GN ORFNames=GLP15_3091 {ECO:0000313|EMBL:EFO63250.1};
OS Giardia intestinalis (strain P15) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=658858 {ECO:0000313|EMBL:EFO63250.1, ECO:0000313|Proteomes:UP000008974};
RN [1] {ECO:0000313|EMBL:EFO63250.1, ECO:0000313|Proteomes:UP000008974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P15 {ECO:0000313|EMBL:EFO63250.1,
RC ECO:0000313|Proteomes:UP000008974};
RX PubMed=20929575; DOI=10.1186/1471-2164-11-543;
RA Jerlstrom-Hultqvist J., Franzen O., Ankarklev J., Xu F., Nohynkova E.,
RA Andersson J.O., Svard S.G., Andersson B.;
RT "Genome analysis and comparative genomics of a Giardia intestinalis
RT assemblage E isolate.";
RL BMC Genomics 11:543-543(2010).
CC -!- FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of
CC DNA into RNA using the four ribonucleoside triphosphates as substrates.
CC Specific core component of RNA polymerase III which synthesizes small
CC RNAs, such as 5S rRNA and tRNAs. {ECO:0000256|RuleBase:RU367076}.
CC -!- SUBUNIT: Component of the RNA polymerase III (Pol III) complex
CC consisting of 17 subunits. {ECO:0000256|RuleBase:RU367076}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367076}.
CC -!- SIMILARITY: Belongs to the eukaryotic RPC3/POLR3C RNA polymerase
CC subunit family. {ECO:0000256|RuleBase:RU367076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFO63250.1}.
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DR EMBL; ACVC01000140; EFO63250.1; -; Genomic_DNA.
DR AlphaFoldDB; E1F2U0; -.
DR STRING; 658858.E1F2U0; -.
DR EnsemblProtists; EFO63250; EFO63250; GLP15_3091.
DR VEuPathDB; GiardiaDB:GLP15_3091; -.
DR OMA; EGMIPRS; -.
DR OrthoDB; 5479617at2759; -.
DR Proteomes; UP000008974; Unassembled WGS sequence.
DR GO; GO:0005666; C:RNA polymerase III complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR013197; RNA_pol_III_RPC82-rel_HTH.
DR InterPro; IPR008806; RNA_pol_III_Rpc82_C.
DR InterPro; IPR039748; RPC3.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR12949:SF0; DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3; 1.
DR PANTHER; PTHR12949; RNA POLYMERASE III DNA DIRECTED -RELATED; 1.
DR Pfam; PF08221; HTH_9; 1.
DR Pfam; PF05645; RNA_pol_Rpc82; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478,
KW ECO:0000256|RuleBase:RU367076}; Nucleus {ECO:0000256|RuleBase:RU367076};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU367076}.
FT DOMAIN 9..68
FT /note="RNA polymerase III subunit RPC82-related helix-turn-
FT helix"
FT /evidence="ECO:0000259|Pfam:PF08221"
FT DOMAIN 148..342
FT /note="RNA polymerase III Rpc82 C -terminal"
FT /evidence="ECO:0000259|Pfam:PF05645"
FT REGION 182..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..204
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 487 AA; 54434 MW; A2469244B6FD4EDA CRC64;
MRFSGFKSVV LSCIEEYFDT TAVAIVQYLM EVAFGTLNDL VTAVRLPPDI IKTSMMALLR
HNIAFFVELP VLRNGHELSR KHMVYGVFSE QAMVRMFCPI VLPRVSDFDG LGDQLLAALT
LGGSMTAPEI LEVLRTMNVD VALPRLLETL STLLSRGVIQ RSSELRERCQ NLITSAYYAH
HHQSHNPKGS ESGEPPRKHS YGLHSLEPDN ISDSGESYCV SVEQLIALFQ EEELADYVCT
VYDRDMGTVF RAALFISNSF QALGFCPFSP ADVRPNTRSF NLEQLHGALI NTQYSLNATG
SNFTLSFCAS VLNLYVSEPK AMVHMTSDGQ YIVDIDTAIE RMQMAVLLRI VAERHGPMAR
RMFNIIRARG MMEASVVAAE GMIPRSQAVS LLTTLCTEGY LQITMLSNSA EPKVETSYFL
YSINPNFSSV AANAAFTCLH NMRSKLKQIE ELQFTLLASN QVQRINDQID LIEPIYIKLI
ETAMLLF
//
