ID   E1F3J4_GIAIA            Unreviewed;      1074 AA.
AC   E1F3J4;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=Protein 21.1 {ECO:0000313|EMBL:EFO62974.1};
GN   ORFNames=GLP15_4350 {ECO:0000313|EMBL:EFO62974.1};
OS   Giardia intestinalis (strain P15) (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=658858 {ECO:0000313|EMBL:EFO62974.1, ECO:0000313|Proteomes:UP000008974};
RN   [1] {ECO:0000313|EMBL:EFO62974.1, ECO:0000313|Proteomes:UP000008974}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P15 {ECO:0000313|EMBL:EFO62974.1,
RC   ECO:0000313|Proteomes:UP000008974};
RX   PubMed=20929575; DOI=10.1186/1471-2164-11-543;
RA   Jerlstrom-Hultqvist J., Franzen O., Ankarklev J., Xu F., Nohynkova E.,
RA   Andersson J.O., Svard S.G., Andersson B.;
RT   "Genome analysis and comparative genomics of a Giardia intestinalis
RT   assemblage E isolate.";
RL   BMC Genomics 11:543-543(2010).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFO62974.1}.
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DR   EMBL; ACVC01000155; EFO62974.1; -; Genomic_DNA.
DR   AlphaFoldDB; E1F3J4; -.
DR   STRING; 658858.E1F3J4; -.
DR   EnsemblProtists; EFO62974; EFO62974; GLP15_4350.
DR   VEuPathDB; GiardiaDB:GLP15_4350; -.
DR   OMA; NIACTRA; -.
DR   OrthoDB; 5475985at2759; -.
DR   Proteomes; UP000008974; Unassembled WGS sequence.
DR   Gene3D; 1.10.287.1490; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR24184:SF11; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR24184; SI:CH211-189E2.2; 1.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   SMART; SM00248; ANK; 7.
DR   SUPFAM; SSF56399; ADP-ribosylation; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 2.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REPEAT          952..979
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REGION          492..553
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          773..801
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          435..486
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          553..714
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        492..539
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1074 AA;  118697 MW;  AD05311EEC1DC4F8 CRC64;
     MSKADSKEWF TAIGARRYTQ VRELLDIYKG FRNSAQDTGL MVAARINDPE LATILAVQEA
     GLINKSDETA LIIAAQLDHP RICEILAPLE KTIYYKDGRN ALMIAAEAGS MNACLALARE
     FPVERDPSGY TALDYSVISN NIACTRAIVD LVRHSQEDFQ FAMDLAERDG RSDIYAYLQM
     ALRKQTQKAE EQEVEMINAT SATVANSCAV RASHAPLHRS GSTPMKATLN RNEIRARSNQ
     KSQTVMRAQT GHSPNYPKHS QYSNNTFHSP TARAVSASGL NNSTAVMNMQ VSLSGSVVGS
     SQLRSLSPGS NLRERTQPGE LAVTNANSVL SAMEYQTIQK NAEVRDLFEQ LKNVTDLRSS
     SLINQLQKYV ANLHMDYDRA VHEKIQMENS LASTVPRRSV SPATVIEQVD GPALHRKKTE
     ILVTSEGEEI SPEQLTEIKK AAKDAEQLRD EVRKLEDEKR TLDVCVNNLT EALQKLKEDN
     AIMVRNAQRF ANFGRGSNSG SEDQIYDKRP STGDMQSSAD CRVASSIGPE STPINSHQEG
     RSRSVDRQQQ SVEKKLREEV RRLQEDLANA SREASSAIDM KARLERQISE INDKAMEYQA
     QVEQANAQKT DAMREKLAVE ERLLELQEEM LELKEELELQ MRGDDQSDKR KVSELEEANR
     ILISENENLI SQLSDMQHDG GDLKHDVSRL TAQLQEAHAQ IADLNNVVDE LSSRNVINTS
     NSEEKRLRET LTAREDDLLR AQMDIESLNT LVGNQQAQIE ELQAKLVSTG GATKFNTTGG
     KKSSSAAQNK RGPPTNLRGE TQSLYEEFAT RSRSELKASA AAQASVLARS QNGKRSGSNL
     AMSRSGEKKY LYTSQGDSVG NASNSGTALR DYAVDKAEHT TRPVSRTKFL SLTLIPPHMS
     AQQILSMREN LDTTCISTAN NRKTDLMEAA EAGDSAHVWK YLNYQAGLQD EEGKTALMYA
     AQKGHIEIVK ALMQKEARIQ THFGTTALMD AACNGHTDIV SILVDYEGGM ATKGDENGES
     AGLTALMLAA HEGHLDCVHI LIRKENSMVC SNGMTARDFA KTDEIRNLLD AFQG
//