ID   E1F3P8_GIAIA            Unreviewed;      2091 AA.
AC   E1F3P8;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   SubName: Full=Kinase {ECO:0000313|EMBL:EFO62920.1};
GN   ORFNames=GLP15_316 {ECO:0000313|EMBL:EFO62920.1};
OS   Giardia intestinalis (strain P15) (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=658858 {ECO:0000313|EMBL:EFO62920.1, ECO:0000313|Proteomes:UP000008974};
RN   [1] {ECO:0000313|EMBL:EFO62920.1, ECO:0000313|Proteomes:UP000008974}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P15 {ECO:0000313|EMBL:EFO62920.1,
RC   ECO:0000313|Proteomes:UP000008974};
RX   PubMed=20929575; DOI=10.1186/1471-2164-11-543;
RA   Jerlstrom-Hultqvist J., Franzen O., Ankarklev J., Xu F., Nohynkova E.,
RA   Andersson J.O., Svard S.G., Andersson B.;
RT   "Genome analysis and comparative genomics of a Giardia intestinalis
RT   assemblage E isolate.";
RL   BMC Genomics 11:543-543(2010).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFO62920.1}.
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DR   EMBL; ACVC01000158; EFO62920.1; -; Genomic_DNA.
DR   STRING; 658858.E1F3P8; -.
DR   EnsemblProtists; EFO62920; EFO62920; GLP15_316.
DR   VEuPathDB; GiardiaDB:GLP15_316; -.
DR   OMA; SSEFICH; -.
DR   OrthoDB; 1663009at2759; -.
DR   Proteomes; UP000008974; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR24345; SERINE/THREONINE-PROTEIN KINASE PLK; 1.
DR   PANTHER; PTHR24345:SF0; SERINE_THREONINE-PROTEIN KINASE PLK1; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:EFO62920.1};
KW   Transferase {ECO:0000313|EMBL:EFO62920.1}.
FT   DOMAIN          68..547
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          1823..1871
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2091 AA;  232156 MW;  D7802AEC30890D3E CRC64;
     MNDSFGLFTT NSIRSENSTE SENSPTYYHT VLEFAVKPIF YPPLKHGQAR DRIWTRVYPD
     GSVSIHEYKL HSQIGKGSYA DVYTAENTIL RRTFVLRMVD RIRLAKALGT QEAADKFLWS
     AASLMDKVQH PNVVRLYEVF FNLLAVPTPY IRHEDVNTSA STQMIHAGVI YSNFGGLFSS
     SQNLAVDSLH LHVSTSFSRP NKNITYDMVK GILSPTHLGQ IFDVNGTSAI RSPDDIDSYN
     NKFIYVIERC HMKDLNSNLK GLSLRDIVII FYQIAHGLEY LHSLLIVHHD IKLENVLIDS
     TDSSSFQSTT SENPHKSSLR YGIDLSNLCN LCSPININNT DTDAIKSLRT WLSPFNPAAS
     ELESPSFYNQ EPNTTKTITQ YEHDIFSSTK YNFAGKNKTR TCKSTNTDFS TNSYSKYWVP
     PISLGAYDSV ETILDTSLTS LKFSKIVPFY IYYSLIFSSQ FDSSNRLAFE HVIKRSNINT
     YPLVAKLSDF DTAKDLSIHG KVLPSLQDLL GKIVHELIEV LIDVFTNNLS SLLTNFDFLD
     AFLEDFFFST INYESDSYQS NILHTNYYVS CENLDQLRPK TKVFNGTNEL KSFLTNSSKC
     GHLQETFTLS TSSSSDLSFA KSTFCTDTTE RVFVPDQTTS DLALPASMTP NDMEVCSSPI
     SSTTQFIAGL TDENPLLGCS DNENSSDPQL IINVGKCCSH SADGTNTLDT GHQEPSCSAL
     EKSGPVLLSD IQTNTSTYSS PSHILHCTVG LTSNPLTFNS LQRHDTSSKS FARRLPRVHR
     TINFSCSQVM LSRRSSSTRR LYLHHLIRYL NKLLILNIQP KILQNFYFLL ELLNTYFTSN
     IFEDKLAERL TTLFSSSEFI CHHPLSKHTF PAYLSSIAGT RHCMPPESLR VWNTPSAATP
     NLYMGMPSDV WQFGVALYAV LIGKHRELPL QRSSEEAMQI STHLSLLLAD LLCGLLAPSP
     MQRYTMVEVV NHPFFDANNF PLSASPDQLF TINFSSKYTP STNSSKEHID NKSGMYQCTE
     SLHHSSAGAS DPGLRSTLFA GVLYPDSLPF SSHVCSSKAN SSNNLIDKIQ AHIDSKEIRK
     SLDLALRFLA KNSAHGEELL KMSLRLRKYH FWVTVRRRDK LVRENRRMFR RSSISNDEIY
     SLLIQTPHNS KQLLLSALQS SKSKDYNVLP RLTNSDKTIM PHKSHSGTLH DERFGTSLEE
     STNSAQDSDS LVTSGIKKAS MLKLYETACS STSNLPIYKA RPRTFLNDDS RHSDWSASKL
     SGGQFDLMNV AAGDNVLDQL HDDIYLMLNT IPWKSSFVRV MPYISNYDHS MVKSMKRKSS
     FHSVFNATGT NFTEMNPFID IEVNIKELSI GANIAFSKLF NLFSLGLLND MTTVHDSGAT
     TVSTRSLEYI FSNSLLKGAG NIWGLIKALK SIQVGVLLEC LVSTVPYFEK LTISRLTWIK
     HLYSTVKAQH NSNSLSLQRT ATNISCTALQ YPSTTALLSA NDPPVSLPNV SGHDSLYKST
     SVRLTTSGIS NIFANQYVHE EATASSSTYT TEIQPYSTDP TSPIRKSNNI SLPHDESVEV
     FYALLSSPSS VPSFIENDSE TMRCYYSVNT DSCVTPESIS STLNGLATIV EEERQISSKD
     ALLTTDLTSI SPSSYSQSLS AKLLTAPVDL TISKVDLHTS TGIFPFDDLC CLSRSKTASE
     CQLEFPPRSA SATTFPKVLP SFATSLQAGF KERLQEGLGE SITSGYSISE CANDILTPLD
     QLESLYPRMV RYSSAMISRS KIPEYPRSSG ILMTQSQQNS NEKLTNDRIM LLHTDTSDST
     GIAALHSQIR TIWAGQASKM GPAVGSSSGQ LSTKGSTNYP SQKTSSQTLR VDSQEKSDST
     RIVSSMQGHK LSLRKHGSTT ALAGIFSDMS MQCKNIERMS RFVSMESSSY SDSTDCETLL
     STALPGKEKT SESCRDHDLP ESNALQLELV NSESLLDVNP SSRINLPGLK NAVKFQKTIL
     NAPAAVNSSF TSRNSSANSL HLYDKANTHL SRSSACIAAT HNQPYLEECP SMASASNNSI
     PSCVLDIFES AIPCEDDVDN VSVAANVTRF LGLDVNNLDN VEIEYSTSTT K
//