ID E1IBK8_9CHLR Unreviewed; 1269 AA.
AC E1IBK8;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=OSCT_0709 {ECO:0000313|EMBL:EFO81427.1};
OS Oscillochloris trichoides DG-6.
OC Bacteria; Chloroflexota; Chloroflexia; Chloroflexales; Chloroflexineae;
OC Oscillochloridaceae; Oscillochloris.
OX NCBI_TaxID=765420 {ECO:0000313|EMBL:EFO81427.1, ECO:0000313|Proteomes:UP000054010};
RN [1] {ECO:0000313|EMBL:EFO81427.1, ECO:0000313|Proteomes:UP000054010}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DG-6 {ECO:0000313|EMBL:EFO81427.1,
RC ECO:0000313|Proteomes:UP000054010};
RX PubMed=21037015; DOI=10.1128/JB.00931-10;
RA Kuznetsov B.B., Ivanovsky R.N., Keppen O.I., Sukhacheva M.V.,
RA Bumazhkin B.K., Patutina E.O., Beletsky A.V., Mardanov A.V., Baslerov R.V.,
RA Panteleeva A.N., Kolganova T.V., Ravin N.V., Skryabin K.G.;
RT "Draft genome sequence of the anoxygenic filamentous phototrophic bacterium
RT Oscillochloris trichoides subsp. DG-6.";
RL J. Bacteriol. 193:321-322(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EFO81427.1}.
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DR EMBL; ADVR01000012; EFO81427.1; -; Genomic_DNA.
DR RefSeq; WP_006561267.1; NZ_GL501401.1.
DR AlphaFoldDB; E1IBK8; -.
DR STRING; 765420.OSCT_0709; -.
DR eggNOG; COG0587; Bacteria.
DR HOGENOM; CLU_001600_0_0_0; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000054010; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000054010};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..72
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
FT REGION 1148..1201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1149..1167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1175..1192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1269 AA; 139533 MW; F7811438E3B6CC76 CRC64;
MKDFIHLHVH SEYSLLDGYA STKAIAGRAA ELGMDSIALT DHGVMYGAME FYDAAKKAGI
KPIIGMEAYM APGSRTEATT RGGKNYFHLL LLAKNEVGYR NLVRLTTRAH LDGMAKGVFA
RPRIDRELLE QYHEGLVVTS ACIAGEVIQQ LTAQQRKQAV ETAAYYRDLL GAENYFLELQ
LHENTPELEG INDELVRIGE ELGIPLVVTN DTHFVRAEDV ETQHRVMAMG MNMTHQEFCN
KGFKMDESYH IMSGEEMWAK FKRYGTAPLE NTRRIADMCN LKLDFGRVQL PQFDLPEGHD
AASYLRLVCE EGLMKRCNGN PPANYIARLD DELDVINATG FPDYMLIVWD YVKYARSRGI
PCLPRGSAGA SLVLYCLGIT DVDPVQNKLL FERFLSRERL EMPDIDTDFA DSRRGEILDY
IAGKYGRENV AQIITYGTLG AKAALRDMGR VLGVELSEVD RVAKLIPSLP VGVTISQALE
RVPELKQIYT TQPHLAEVID WAKKVEGRMR NVGTHACGVV VSRTPLEEMV PLQRTTKDEH
AVMASFEGPT LAKMGLLKMD ILGLTNLSVV AEALNYIERS TGIKMELADI PLEDKKTFEA
LGRGETKNVF QLESAGMTRY LMQLKPTRVD DLYAMVALYR PGPLEQIPHY IQGKNDPANI
TYLHPILKPI LEDTYGVIVY QEQIMQLLQT VADYTLGQAY IVIKAISKKN KELMAENGAK
FKEGCLKKGI SAQVADELWE LILPFAGYSF NRPHATLYGL LSYQTAWLKV NYPVEYMAAV
LTGAGGVIED VAKAALETRR LGVALLPPDV NHSQKGFEIE PIQGQLPNGV RYQNAIRFGL
AAIKNVGEGP LDAILEARTE GGAFSTLEDL CARVDRNAIN KRVLESLIKA GALDSLPGTR
RQKLTVLDQA ISAATEAQKA RDVGQASLFD MMGESSGNDG SINVPRINLP PITTTPADMK
EELLWERELL GLNITNDPVS QALTGVNWTG ITRLNEITEE HIGKSFKFIG LLSGVRHIST
KKGDAMLVGV VDDATGTIEM VVFPKVLSKS GDLLQNDAVV KLAAKVDNRR DTPQLVVESV
EAVDVDSAPG AVAVEMDLDG VTEHLEEPTP MEETPMVAPP RIERSVAEAP VAAPATPISV
IPHREAVTLK SNGNGNGHSN GNGKAAPKNP QRSAPIPATA ESSSSATPSF SGRTLRIRLP
RTSDRDADVR LMQDVHNVLL TSSGMDRVRL YMPNGVGIVV LESAHTVDCT PNLLADLRDV
LGSDWVRVE
//
