ID E1QVM5_OLSUV Unreviewed; 459 AA.
AC E1QVM5;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=thiamine diphosphokinase {ECO:0000256|ARBA:ARBA00013245};
DE EC=2.7.6.2 {ECO:0000256|ARBA:ARBA00013245};
GN OrderedLocusNames=Olsu_1068 {ECO:0000313|EMBL:ADK68178.1};
OS Olsenella uli (strain ATCC 49627 / DSM 7084 / CIP 109912 / JCM 12494 /
OS NCIMB 702895 / VPI D76D-27C) (Lactobacillus uli).
OC Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales; Atopobiaceae;
OC Olsenella.
OX NCBI_TaxID=633147 {ECO:0000313|EMBL:ADK68178.1, ECO:0000313|Proteomes:UP000000333};
RN [1] {ECO:0000313|EMBL:ADK68178.1, ECO:0000313|Proteomes:UP000000333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49627 / DSM 7084 / CIP 109912 / JCM 12494 / NCIMB 702895 /
RC VPI D76D-27C {ECO:0000313|Proteomes:UP000000333};
RX PubMed=21304694; DOI=10.4056/sigs.1082860;
RA Goker M., Held B., Lucas S., Nolan M., Yasawong M., Glavina Del Rio T.,
RA Tice H., Cheng J.F., Bruce D., Detter J.C., Tapia R., Han C., Goodwin L.,
RA Pitluck S., Liolios K., Ivanova N., Mavromatis K., Mikhailova N., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Rohde M., Sikorski J., Pukall R., Woyke T., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., Lapidus A.;
RT "Complete genome sequence of Olsenella uli type strain (VPI D76D-27C).";
RL Stand. Genomic Sci. 3:76-84(2010).
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DR EMBL; CP002106; ADK68178.1; -; Genomic_DNA.
DR RefSeq; WP_013251930.1; NZ_JQCO01000001.1.
DR AlphaFoldDB; E1QVM5; -.
DR STRING; 633147.Olsu_1068; -.
DR GeneID; 78512488; -.
DR KEGG; ols:Olsu_1068; -.
DR PATRIC; fig|633147.7.peg.476; -.
DR eggNOG; COG0637; Bacteria.
DR eggNOG; COG1564; Bacteria.
DR HOGENOM; CLU_612290_0_0_11; -.
DR Proteomes; UP000000333; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0030975; F:thiamine binding; IEA:InterPro.
DR GO; GO:0004788; F:thiamine diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009229; P:thiamine diphosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0006772; P:thiamine metabolic process; IEA:InterPro.
DR CDD; cd07505; HAD_BPGM-like; 1.
DR CDD; cd07995; TPK; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 3.40.50.10240; Thiamin pyrophosphokinase, catalytic domain; 1.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006439; HAD-SF_hydro_IA.
DR InterPro; IPR041492; HAD_2.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR023198; PGP-like_dom2.
DR InterPro; IPR006282; Thi_PPkinase.
DR InterPro; IPR007373; Thiamin_PyroPKinase_B1-bd.
DR InterPro; IPR036371; TPK_B1-bd_sf.
DR InterPro; IPR007371; TPK_catalytic.
DR InterPro; IPR036759; TPK_catalytic_sf.
DR NCBIfam; TIGR01509; HAD-SF-IA-v3; 1.
DR NCBIfam; TIGR01378; thi_PPkinase; 1.
DR PANTHER; PTHR41299; THIAMINE PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR41299:SF1; THIAMINE PYROPHOSPHOKINASE; 1.
DR Pfam; PF13419; HAD_2; 1.
DR Pfam; PF04265; TPK_B1_binding; 1.
DR Pfam; PF04263; TPK_catalytic; 1.
DR SFLD; SFLDG01129; C1.5:_HAD__Beta-PGM__Phosphata; 1.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SMART; SM00983; TPK_B1_binding; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF63999; Thiamin pyrophosphokinase, catalytic domain; 1.
DR SUPFAM; SSF63862; Thiamin pyrophosphokinase, substrate-binding domain; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ADK68178.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000333};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 396..454
FT /note="Thiamin pyrophosphokinase thiamin-binding"
FT /evidence="ECO:0000259|SMART:SM00983"
SQ SEQUENCE 459 AA; 49069 MW; 88531E85DA41A8A1 CRC64;
MPIKAAIFDC DGTLVDSMPL WHDVTVELLR RHHVADAEEA FVRTESLPMV EMCHAFHDEW
GVEAEGEELV RELVDMVREG YRSRVSLLPG CRAFLDELAS AGVRMVVASS TAPEELSVAL
SAQGVDGYFE RVFSTGGPIR SKDYPDIWEL VLDYLGTDPA DTWVFEDAPF GMRTARSVGA
NTVCLFSPHG DRDLAACERY ADILVHSYHE LSLALLDDYA RPPQASPSAH PRLAPLRVLV
VGASPERPSS ALLRSLAAST DYVIAADAGA DALRSCGIAP DVFCGDADSA TGESAAWARS
VARADIEFPS EKYATDLALA ISCARHEAAR RNARLELTLT GVTGGRPDHA LAVVGQLARN
ADASPRIVED GFECRLLSPS GTACWELGGA HVPAAGVEGT LFSAIPVAEG TMLSERGFKW
ELDHRELPLL GDEGISNVVT SATASVECHA GAVAAFLLA
//
