ID E1QZM7_OLSUV Unreviewed; 682 AA.
AC E1QZM7;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Methionyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030904};
GN OrderedLocusNames=Olsu_0727 {ECO:0000313|EMBL:ADK67841.1};
OS Olsenella uli (strain ATCC 49627 / DSM 7084 / CIP 109912 / JCM 12494 /
OS NCIMB 702895 / VPI D76D-27C) (Lactobacillus uli).
OC Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales; Atopobiaceae;
OC Olsenella.
OX NCBI_TaxID=633147 {ECO:0000313|EMBL:ADK67841.1, ECO:0000313|Proteomes:UP000000333};
RN [1] {ECO:0000313|EMBL:ADK67841.1, ECO:0000313|Proteomes:UP000000333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49627 / DSM 7084 / CIP 109912 / JCM 12494 / NCIMB 702895 /
RC VPI D76D-27C {ECO:0000313|Proteomes:UP000000333};
RX PubMed=21304694; DOI=10.4056/sigs.1082860;
RA Goker M., Held B., Lucas S., Nolan M., Yasawong M., Glavina Del Rio T.,
RA Tice H., Cheng J.F., Bruce D., Detter J.C., Tapia R., Han C., Goodwin L.,
RA Pitluck S., Liolios K., Ivanova N., Mavromatis K., Mikhailova N., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Rohde M., Sikorski J., Pukall R., Woyke T., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., Lapidus A.;
RT "Complete genome sequence of Olsenella uli type strain (VPI D76D-27C).";
RL Stand. Genomic Sci. 3:76-84(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-
CC methionyl-tRNA(Met); Xref=Rhea:RHEA:13481, Rhea:RHEA-COMP:9667,
CC Rhea:RHEA-COMP:9698, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:57844, ChEBI:CHEBI:78442, ChEBI:CHEBI:78530,
CC ChEBI:CHEBI:456215; EC=6.1.1.10;
CC Evidence={ECO:0000256|ARBA:ARBA00001234};
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC MetG type 1 subfamily. {ECO:0000256|ARBA:ARBA00008258}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002106; ADK67841.1; -; Genomic_DNA.
DR RefSeq; WP_013251593.1; NZ_JQCO01000001.1.
DR AlphaFoldDB; E1QZM7; -.
DR STRING; 633147.Olsu_0727; -.
DR GeneID; 78512145; -.
DR KEGG; ols:Olsu_0727; -.
DR PATRIC; fig|633147.7.peg.821; -.
DR eggNOG; COG0143; Bacteria.
DR HOGENOM; CLU_408071_0_0_11; -.
DR OrthoDB; 9810191at2; -.
DR Proteomes; UP000000333; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006418; P:tRNA aminoacylation for protein translation; IEA:InterPro.
DR Gene3D; 2.170.220.10; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR InterPro; IPR023458; Met-tRNA_ligase_1.
DR InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR PANTHER; PTHR45765; METHIONINE--TRNA LIGASE; 1.
DR PANTHER; PTHR45765:SF1; METHIONINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR Pfam; PF09334; tRNA-synt_1g; 2.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363039};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363039};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363039};
KW Reference proteome {ECO:0000313|Proteomes:UP000000333}.
FT DOMAIN 19..251
FT /note="Methionyl/Leucyl tRNA synthetase"
FT /evidence="ECO:0000259|Pfam:PF09334"
FT DOMAIN 314..475
FT /note="Methionyl/Leucyl tRNA synthetase"
FT /evidence="ECO:0000259|Pfam:PF09334"
SQ SEQUENCE 682 AA; 76463 MW; 45A4B01584BB778B CRC64;
MADTSTPTAG RPSFPRRAVI TGGMPYGNKN LHFGHIGGVF VPADFFARFL RDRLGADNVV
FVSGTDCYGS PIMEGYRKKV EDDGYTGSIV DYVGANHDAQ RAALDAYGIS LDLFAGSGTK
DAAPYHERLT SEVIARLYER GHLHRMSTRQ FFDVEANQFL NGRQVIGRCP VRGCKSERAY
ADECDLGHQF EPEELISPVS QLTGTTPELR PVDNWYFDLP AFKGRLEGLV DAWDTDEQVR
PVVTKTVRES LAAPVMYIQD KFRDEFDAIA DRLPAHALRE PERGQQSFSV EFADWEQRDQ
ARSVLEEAHV RFRTGKTLLP FRITGNIDWG VPAPVLEDVR DLTVWCWPES LWAPISFTQA
LLDADARSGG MRYSSDDWRD WWCADDAKVY QFIGQDNIYF YCVAQPALWD ALDWGLSQDV
PVANYHILFM NRKASSSGAI KPPMATELLD HYSAEQLRCH WLSLGLDQRA VSFSPKPYDT
SVSHRDRKTG RDVLVRDDPR VVDPALKESA FLTNIFNRLA RSCLYGTQSA CAGHLPTLAA
HDDVMAACRE VTLRFERLAH GFDAHNALAA VDAFARAANK RWGEASKAAQ GDDVAYEQAL
ADAFQALRTV TLLMHPATPS GCEKVCEHLG FDSDLFFDWE HAFDSIAQLC QAQGTTPATH
QTVGLPPRFD FFERHPSQIR QK
//
