ID E1R009_OLSUV Unreviewed; 677 AA.
AC E1R009;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:ADK67973.1};
DE EC=2.4.1.129 {ECO:0000313|EMBL:ADK67973.1};
GN OrderedLocusNames=Olsu_0861 {ECO:0000313|EMBL:ADK67973.1};
OS Olsenella uli (strain ATCC 49627 / DSM 7084 / CIP 109912 / JCM 12494 /
OS NCIMB 702895 / VPI D76D-27C) (Lactobacillus uli).
OC Bacteria; Actinomycetota; Coriobacteriia; Coriobacteriales; Atopobiaceae;
OC Olsenella.
OX NCBI_TaxID=633147 {ECO:0000313|EMBL:ADK67973.1, ECO:0000313|Proteomes:UP000000333};
RN [1] {ECO:0000313|EMBL:ADK67973.1, ECO:0000313|Proteomes:UP000000333}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49627 / DSM 7084 / CIP 109912 / JCM 12494 / NCIMB 702895 /
RC VPI D76D-27C {ECO:0000313|Proteomes:UP000000333};
RX PubMed=21304694; DOI=10.4056/sigs.1082860;
RA Goker M., Held B., Lucas S., Nolan M., Yasawong M., Glavina Del Rio T.,
RA Tice H., Cheng J.F., Bruce D., Detter J.C., Tapia R., Han C., Goodwin L.,
RA Pitluck S., Liolios K., Ivanova N., Mavromatis K., Mikhailova N., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D.,
RA Rohde M., Sikorski J., Pukall R., Woyke T., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P., Lapidus A.;
RT "Complete genome sequence of Olsenella uli type strain (VPI D76D-27C).";
RL Stand. Genomic Sci. 3:76-84(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; CP002106; ADK67973.1; -; Genomic_DNA.
DR RefSeq; WP_013251725.1; NZ_JQCO01000001.1.
DR AlphaFoldDB; E1R009; -.
DR STRING; 633147.Olsu_0861; -.
DR GeneID; 78512278; -.
DR KEGG; ols:Olsu_0861; -.
DR PATRIC; fig|633147.7.peg.688; -.
DR eggNOG; COG0768; Bacteria.
DR HOGENOM; CLU_009289_1_2_11; -.
DR OrthoDB; 9766847at2; -.
DR Proteomes; UP000000333; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000313|EMBL:ADK67973.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000333};
KW Transferase {ECO:0000313|EMBL:ADK67973.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 59..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 103..275
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 322..658
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 677 AA; 71749 MW; 2BC0C8EA1483FB90 CRC64;
MNPIVVVIIV LAVILVALVA VFFLVGRGEA RFTFDIGGAV PRAAGGSDTS SESGFKSRLN
GLGVFSGSII ATLLVKLWTM QLVSSDSYSA QAESNRTRTI SLAAPRGRIL DRNGVELVGN
RASLSVMAEA SVADNEIECK LLGNLIGMPE MAVRRKIEDA SEGAQSLRTV AVDVSRRVVA
YINERSYLFA GVSVAEKAQR HYPLGNVAAH VLGYTGTVSS DQLGSTGGSD VEGAIRYESG
DIVGQAGVEY QYESVLQGIK GEQTVYVDAD GNVLSHTGSV DAQSGSDIVL TLDANIQKAA
EESLQGRIKT LYGAGKTECK GGCAIAMDVT NGEILAMASA PTFYPNVFVG GISTDDWDEL
SSEEGANPLM NRAVAGQYPS ASTIKPLSTL AALDYGIAGA DSGYDCTGYW TGFGKDYGQY
CWNHSGHGWM TLQTGITYSC DVVFYEVGKG FYYSDSKEGL QETYRAWGLG SAEGVDLPSE
SVGRVPDAEW KWNYYTSSDD SARSWQGGDS TNLAIGQGDL LVTPLQMLCA YAGLATGGTT
WRPHVLKSVK SNVGGGSVID YKCEVLRQID IEPSHLDLVH AGLTGVIYEE SEAQASHFTN
LSVRVAGKTG TAETPKKDPT GWFIAYAPSD DPKYVVASVI ENGGYGSEGA MYVVRDILGA
IYNEPDDSTA VDTSGVQ
//
