ID E1R3B9_SEDSS Unreviewed; 502 AA.
AC E1R3B9;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Protease Do {ECO:0000313|EMBL:ADK81550.1};
DE EC=3.4.21.108 {ECO:0000313|EMBL:ADK81550.1};
GN OrderedLocusNames=Spirs_2436 {ECO:0000313|EMBL:ADK81550.1};
OS Sediminispirochaeta smaragdinae (strain DSM 11293 / JCM 15392 / SEBR 4228)
OS (Spirochaeta smaragdinae).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Spirochaetaceae;
OC Sediminispirochaeta.
OX NCBI_TaxID=573413 {ECO:0000313|EMBL:ADK81550.1, ECO:0000313|Proteomes:UP000002318};
RN [1] {ECO:0000313|EMBL:ADK81550.1, ECO:0000313|Proteomes:UP000002318}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11293 / JCM 15392 / SEBR 4228
RC {ECO:0000313|Proteomes:UP000002318};
RX PubMed=21304743; DOI=10.4056/sigs.1143106;
RA Mavromatis K., Yasawong M., Chertkov O., Lapidus A., Lucas S., Nolan M.,
RA Del Rio T.G., Tice H., Cheng J.F., Pitluck S., Liolios K., Ivanova N.,
RA Tapia R., Han C., Bruce D., Goodwin L., Pati A., Chen A., Palaniappan K.,
RA Land M., Hauser L., Chang Y.J., Jeffries C.D., Detter J.C., Rohde M.,
RA Brambilla E., Spring S., Goker M., Sikorski J., Woyke T., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Klenk H.P., Kyrpides N.C.;
RT "Complete genome sequence of Spirochaeta smaragdinae type strain (SEBR
RT 4228).";
RL Stand. Genomic Sci. 3:136-144(2010).
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DR EMBL; CP002116; ADK81550.1; -; Genomic_DNA.
DR RefSeq; WP_013255013.1; NC_014364.1.
DR AlphaFoldDB; E1R3B9; -.
DR STRING; 573413.Spirs_2436; -.
DR KEGG; ssm:Spirs_2436; -.
DR eggNOG; COG0265; Bacteria.
DR HOGENOM; CLU_020120_1_0_12; -.
DR OrthoDB; 9758917at2; -.
DR Proteomes; UP000002318; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00987; PDZ_serine_protease; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 2.40.10.120; -; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011782; Pept_S1C_Do.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR001940; Peptidase_S1C.
DR NCBIfam; TIGR02037; degP_htrA_DO; 1.
DR PANTHER; PTHR22939; SERINE PROTEASE FAMILY S1C HTRA-RELATED; 1.
DR PANTHER; PTHR22939:SF129; SERINE PROTEASE HTRA2, MITOCHONDRIAL; 1.
DR Pfam; PF13180; PDZ_2; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SMART; SM00228; PDZ; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ADK81550.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:ADK81550.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002318};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 297..361
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT ACT_SITE 147
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR611782-1"
FT ACT_SITE 177
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR611782-1"
FT ACT_SITE 251
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR611782-1"
SQ SEQUENCE 502 AA; 54759 MW; 6D71A764B0234252 CRC64;
MNGKKLFRSK NFFVFNLLLV GLVAGFVVSM ITFGCSTRLS SGETAYAQEK QADPIQVPPS
MEEMQNSFRA VARKSLPVVV EVKVVEVVKQ AVPQSRGWPW DFLFPDQQNN NQGQQQPQER
EYRNQGLGSG VIVRNNGNTH YVLTNNHVAG KADEIKVVLN DGREYPAKLV GADERMDLAM
VSFDAKEDIP VAEIGDSDEL QVGDWVIAVG SPFGFVSSVT AGIVSAKGRS GPQNNISDFI
QTDAAINQGN SGGALMNIYG QVVGINTWIA APSGGSVGLG FAIPINNAKK AIDDFIDKGE
IEYGWLGVTV SELYPGMEES MGIDNQKGAF IQNVYIDSPA AKGGIEPGDF VTAIDNRSVR
SRDDLVRMVG ELTAGSSVDF DIIRDGKKIT LKVKIGKREN SEAIAGNMSK LWPGLTVIGL
DEDVRNELKI NAKENGVVVV GVEKGTKPYV AGIRNYDLIY RINDTQINNV GDFYDAMNDK
NVKEYKIYYK REGSEFFAGI VR
//
