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Database: UniProt
Entry: E1RDP9_METP4
LinkDB: E1RDP9_METP4
Original site: E1RDP9_METP4 
ID   E1RDP9_METP4            Unreviewed;       328 AA.
AC   E1RDP9;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   16-JAN-2019, entry version 42.
DE   SubName: Full=Homoserine dehydrogenase {ECO:0000313|EMBL:ADN36002.1};
DE            EC=1.1.1.3 {ECO:0000313|EMBL:ADN36002.1};
GN   OrderedLocusNames=Mpet_1242 {ECO:0000313|EMBL:ADN36002.1};
OS   Methanolacinia petrolearia (strain DSM 11571 / OCM 486 / SEBR 4847)
OS   (Methanoplanus petrolearius).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanomicrobiales; Methanomicrobiaceae; Methanolacinia.
OX   NCBI_TaxID=679926 {ECO:0000313|EMBL:ADN36002.1, ECO:0000313|Proteomes:UP000006565};
RN   [1] {ECO:0000313|EMBL:ADN36002.1, ECO:0000313|Proteomes:UP000006565}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 11571 / OCM 486 / SEBR 4847
RC   {ECO:0000313|Proteomes:UP000006565};
RX   PubMed=21304750;
RA   Brambilla E., Djao O.D., Daligault H., Lapidus A., Lucas S.,
RA   Hammon N., Nolan M., Tice H., Cheng J.F., Han C., Tapia R.,
RA   Goodwin L., Pitluck S., Liolios K., Ivanova N., Mavromatis K.,
RA   Mikhailova N., Pati A., Chen A., Palaniappan K., Land M., Hauser L.,
RA   Chang Y.J., Jeffries C.D., Rohde M., Spring S., Sikorski J., Goker M.,
RA   Woyke T., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P.;
RT   "Complete genome sequence of Methanoplanus petrolearius type strain
RT   (SEBR 4847).";
RL   Stand. Genomic Sci. 3:203-211(2010).
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DR   EMBL; CP002117; ADN36002.1; -; Genomic_DNA.
DR   RefSeq; WP_013329180.1; NC_014507.1.
DR   STRING; 679926.Mpet_1242; -.
DR   EnsemblBacteria; ADN36002; ADN36002; Mpet_1242.
DR   GeneID; 9743708; -.
DR   KEGG; mpi:Mpet_1242; -.
DR   eggNOG; arCOG01351; Archaea.
DR   eggNOG; COG0460; LUCA.
DR   HOGENOM; HOG000076616; -.
DR   KO; K00003; -.
DR   OMA; FEASVCG; -.
DR   OrthoDB; 102435at2157; -.
DR   BioCyc; MPET679926:G1GN5-1262-MONOMER; -.
DR   Proteomes; UP000006565; Chromosome.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR022697; HDH_short.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF036497; HDH_short; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006565};
KW   NADP {ECO:0000256|PIRSR:PIRSR036497-2};
KW   Oxidoreductase {ECO:0000313|EMBL:ADN36002.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006565}.
FT   DOMAIN        7    135       NAD_binding_3. {ECO:0000259|Pfam:
FT                                PF03447}.
FT   DOMAIN      143    318       Homoserine_dh. {ECO:0000259|Pfam:
FT                                PF00742}.
FT   NP_BIND       7     12       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   ACT_SITE    211    211       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR036497-1}.
FT   BINDING     111    111       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     196    196       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR036497-2}.
SQ   SEQUENCE   328 AA;  35222 MW;  8D2993E67C33E80B CRC64;
     MKIAILGFGS VGRGIAQIVA ERDTGLVITA VADSKSGCID NNGIDPLELI NRKEETGLCG
     EKGITAEYII ENAEYDALVE VTPTNAETAE PSLGYIRLAL SRGRNVVTSN KGPIAKNYAE
     LKDLADKNGV RLKYEATVCG AIPIIHTLQY SLAGNKVKRL YGIFNGTCNY ILTRMADEKL
     TYKEALLEAR ELGYAEADPT YDVEGIDAAI KLVILANAIF GMNKKIEDVE ITGINSLTSQ
     ALELAEEDEL TIRLIGEINN EKGILKVSPR VIPKNHTLVV RDTLNAVTID TDLAGEITLI
     GKGAGSIETA SAIISDLLFI SNCHDGSP
//
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