ID E1RDX0_METP4 Unreviewed; 94 AA.
AC E1RDX0;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit B {ECO:0000256|ARBA:ARBA00015127, ECO:0000256|HAMAP-Rule:MF_01094};
DE EC=2.1.1.86 {ECO:0000256|ARBA:ARBA00012514, ECO:0000256|HAMAP-Rule:MF_01094};
DE AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit B {ECO:0000256|ARBA:ARBA00029818, ECO:0000256|HAMAP-Rule:MF_01094};
GN Name=mtrB {ECO:0000256|HAMAP-Rule:MF_01094};
GN OrderedLocusNames=Mpet_2411 {ECO:0000313|EMBL:ADN37157.1};
OS Methanolacinia petrolearia (strain DSM 11571 / OCM 486 / SEBR 4847)
OS (Methanoplanus petrolearius).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales; Methanomicrobiaceae; Methanolacinia.
OX NCBI_TaxID=679926 {ECO:0000313|EMBL:ADN37157.1, ECO:0000313|Proteomes:UP000006565};
RN [1] {ECO:0000313|EMBL:ADN37157.1, ECO:0000313|Proteomes:UP000006565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 11571 / OCM 486 / SEBR 4847
RC {ECO:0000313|Proteomes:UP000006565};
RX PubMed=21304750;
RA Brambilla E., Djao O.D., Daligault H., Lapidus A., Lucas S., Hammon N.,
RA Nolan M., Tice H., Cheng J.F., Han C., Tapia R., Goodwin L., Pitluck S.,
RA Liolios K., Ivanova N., Mavromatis K., Mikhailova N., Pati A., Chen A.,
RA Palaniappan K., Land M., Hauser L., Chang Y.J., Jeffries C.D., Rohde M.,
RA Spring S., Sikorski J., Goker M., Woyke T., Bristow J., Eisen J.A.,
RA Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Methanoplanus petrolearius type strain (SEBR
RT 4847).";
RL Stand. Genomic Sci. 3:203-211(2010).
CC -!- FUNCTION: Part of a complex that catalyzes the formation of methyl-
CC coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-
CC tetrahydromethanopterin. This is an energy-conserving, sodium-ion
CC translocating step. {ECO:0000256|ARBA:ARBA00002533, ECO:0000256|HAMAP-
CC Rule:MF_01094}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2
CC Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2
CC Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286,
CC ChEBI:CHEBI:58319; EC=2.1.1.86;
CC Evidence={ECO:0000256|ARBA:ARBA00001816, ECO:0000256|HAMAP-
CC Rule:MF_01094};
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-
CC coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step
CC 2/2. {ECO:0000256|ARBA:ARBA00004839, ECO:0000256|HAMAP-Rule:MF_01094}.
CC -!- SUBUNIT: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD,
CC MtrE, MtrF, MtrG and MtrH. {ECO:0000256|ARBA:ARBA00011616,
CC ECO:0000256|HAMAP-Rule:MF_01094}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162,
CC ECO:0000256|HAMAP-Rule:MF_01094}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004162, ECO:0000256|HAMAP-Rule:MF_01094}.
CC Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the MtrB family. {ECO:0000256|ARBA:ARBA00010027,
CC ECO:0000256|HAMAP-Rule:MF_01094}.
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DR EMBL; CP002117; ADN37157.1; -; Genomic_DNA.
DR RefSeq; WP_013330334.1; NC_014507.1.
DR AlphaFoldDB; E1RDX0; -.
DR STRING; 679926.Mpet_2411; -.
DR GeneID; 9744904; -.
DR KEGG; mpi:Mpet_2411; -.
DR eggNOG; arCOG04867; Archaea.
DR HOGENOM; CLU_171544_1_0_2; -.
DR OrthoDB; 114034at2157; -.
DR UniPathway; UPA00640; UER00698.
DR Proteomes; UP000006565; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01094; MtrB; 1.
DR InterPro; IPR008690; MtrB_MeTrfase.
DR NCBIfam; TIGR04166; methano_MtrB; 1.
DR Pfam; PF05440; MtrB; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01094};
KW Membrane {ECO:0000256|HAMAP-Rule:MF_01094};
KW Methanogenesis {ECO:0000256|HAMAP-Rule:MF_01094};
KW Methyltransferase {ECO:0000256|HAMAP-Rule:MF_01094,
KW ECO:0000313|EMBL:ADN37157.1};
KW One-carbon metabolism {ECO:0000256|HAMAP-Rule:MF_01094};
KW Reference proteome {ECO:0000313|Proteomes:UP000006565};
KW Transferase {ECO:0000256|HAMAP-Rule:MF_01094, ECO:0000313|EMBL:ADN37157.1};
KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_01094};
KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01094}.
FT TRANSMEM 74..93
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01094"
SQ SEQUENCE 94 AA; 9787 MW; 40EC07FC67D3DD30 CRC64;
MGYIQVLPEF GLVADPVVGL VTTAGASLAP ILDEIGEVEK IADDIVGMLS GEGNFLASFP
HREKSLVYAG SVTAMWYGMA VGLLIAGLFA FALI
//
