ID E1SAL4_PANVC Unreviewed; 521 AA.
AC E1SAL4;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=diguanylate cyclase {ECO:0000256|ARBA:ARBA00012528};
DE EC=2.7.7.65 {ECO:0000256|ARBA:ARBA00012528};
GN OrderedLocusNames=Pvag_2239 {ECO:0000313|EMBL:ADO10412.1};
OS Pantoea vagans (strain C9-1) (Pantoea agglomerans (strain C9-1)).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Pantoea.
OX NCBI_TaxID=712898 {ECO:0000313|EMBL:ADO10412.1, ECO:0000313|Proteomes:UP000006631};
RN [1] {ECO:0000313|EMBL:ADO10412.1, ECO:0000313|Proteomes:UP000006631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C9-1 {ECO:0000313|EMBL:ADO10412.1,
RC ECO:0000313|Proteomes:UP000006631};
RX PubMed=20952567; DOI=10.1128/JB.01122-10;
RA Smits T.H., Rezzonico F., Kamber T., Goesmann A., Ishimaru C.A.,
RA Stockwell V.O., Frey J.E., Duffy B.;
RT "The genome sequence of the biocontrol agent Pantoea vagans strain C9-1.";
RL J. Bacteriol. 192:6486-6487(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 GTP = 3',3'-c-di-GMP + 2 diphosphate; Xref=Rhea:RHEA:24898,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:58805; EC=2.7.7.65;
CC Evidence={ECO:0000256|ARBA:ARBA00034247};
CC -!- PATHWAY: Purine metabolism; 3',5'-cyclic di-GMP biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004665}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP002206; ADO10412.1; -; Genomic_DNA.
DR RefSeq; WP_013358689.1; NC_014562.1.
DR AlphaFoldDB; E1SAL4; -.
DR KEGG; pva:Pvag_2239; -.
DR eggNOG; COG2199; Bacteria.
DR HOGENOM; CLU_000445_134_6_6; -.
DR OrthoDB; 9812260at2; -.
DR Proteomes; UP000006631; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd18773; PDC1_HK_sensor; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR029151; Sensor-like_sf.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR45138:SF9; DIGUANYLATE CYCLASE DGCM-RELATED; 1.
DR PANTHER; PTHR45138; REGULATORY COMPONENTS OF SENSORY TRANSDUCTION SYSTEM; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF00990; GGDEF; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF103190; Sensory domain-like; 1.
DR PROSITE; PS50887; GGDEF; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 390..521
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
SQ SEQUENCE 521 AA; 56754 MW; D7227365FFD31330 CRC64;
MLKLFRPKAD LRNLIALLVI VSIVITLANT LYATWRVQRQ VLIDTTLEAN RAYAAKLAST
SEIFFQLAQS QLHYSANQLS RDFNNEALLE SEVSRLREQT SSFNSVAIVD AQGVIKAISP
ESLTLKGMHL TSDASREALT LRQPSISKPT LSAANNLLVF ISWPVWSADG DYLGYIGGTI
YLKKKSILNA LLGEQFYRDG TTVYVLDSNN EVLYHQNRQL VGKTLPAIVS PRDEQTNGSL
MLAGPGESAQ LAGFAIVPTT GWTVVALKPI NVTLDPLSGL LMKVLKNSVP FALLTLLVAV
VLARLIARPL FQLARKASRM DAQGVSKEIG GITAWYFEAA QVKRALLTGI GLVQDKIGRL
SSEAQTDPLT QLLNRRGLNA VLEYYRTLRQ PFSVLALDID HFKNVNDSWG HDVGDRVIQQ
VASTLRASAR QSDVVCRNGG EEFLMLLPGT ALDEAQIIAE RVRLGIAEAW LTDVGRITLS
IGVAAWNGTQ DAGLETSLKQ ADAALYAAKN AGRNCVIVAT A
//
