ID   E1TBJ7_BURSG            Unreviewed;       673 AA.
AC   E1TBJ7;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   RecName: Full=Tetrapyrrole biosynthesis uroporphyrinogen III synthase domain-containing protein {ECO:0000259|Pfam:PF02602};
GN   OrderedLocusNames=BC1003_0919 {ECO:0000313|EMBL:ADN56903.1};
OS   Burkholderia sp. (strain CCGE1003).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia.
OX   NCBI_TaxID=640512 {ECO:0000313|EMBL:ADN56903.1};
RN   [1] {ECO:0000313|EMBL:ADN56903.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CCGE1003 {ECO:0000313|EMBL:ADN56903.1};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Daligault H., Davenport K., Detter J.C., Han C., Tapia R.,
RA   Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Ovchinnikova G.,
RA   Martinez-Romero E., Rogel M.A., Auchtung J., Tiedje J.M., Woyke T.;
RT   "Complete sequence of chromosome1 of Burkholderia sp. CCGE1003.";
RL   Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP002217; ADN56903.1; -; Genomic_DNA.
DR   AlphaFoldDB; E1TBJ7; -.
DR   STRING; 640512.BC1003_0919; -.
DR   KEGG; bgf:BC1003_0919; -.
DR   eggNOG; COG1587; Bacteria.
DR   eggNOG; COG2959; Bacteria.
DR   HOGENOM; CLU_015149_0_0_4; -.
DR   OrthoDB; 9787650at2; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR   GO; GO:0033014; P:tetrapyrrole biosynthetic process; IEA:InterPro.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR007470; HemX.
DR   PANTHER; PTHR38043; PROTEIN HEMX; 1.
DR   PANTHER; PTHR38043:SF1; PROTEIN HEMX; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   Pfam; PF04375; HemX; 1.
DR   SUPFAM; SSF69618; HemD-like; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        343..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          32..268
FT                   /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT                   synthase"
FT                   /evidence="ECO:0000259|Pfam:PF02602"
FT   REGION          290..334
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          366..432
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        290..333
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   673 AA;  71488 MW;  9CDB10375575618A CRC64;
     MAADTPRNAS SSGAGQAAFT VVITRPAGQS SELIARLAAA GVATLDFPLI DIAPVADDTP
     LRAALGSLER YALVVFVSPN AIDHAFAKSG AIWPHALPLG VVGPGSVRAL ARHGVSAPAY
     QVISPAAGVD DENGRFDSEG LYAAIEAALG ETGLEGKRVL IVRGDGGREW LADRLREAGA
     QVETVAAYRR LVPEPSIGAW ARVHQLLAGE AHAWLLTSSE GVRNLHELAH EHLTADEIAQ
     LKRALLVTPH PRIAQTARAL GFDRITVSGA GDERIAQALL AALPTVVQPV PSNPAHSPAQ
     SRMTETNAST NASPQPAATA SLPPNQPFTP YEAQKRRSAS GPLLWFVVVV LACAAGVGGY
     ALNRKLERTE QQIAQRQQAN DTQTNELRIK TEQALATVRQ SDSQVAQLEG KLADAQAAQQ
     ALQQQYADLA RNRDDWTLAE VGQMLSAASQ QLQLTGNTQL ALFALQSADT RLAASDSAQA
     VAVRKAIAQD IDKLKAAPST DLTGLAIKLD NAVDQVDSLP LSGEAPIAHA TPRAATWADT
     AKVAAATGEP RWKVWWREVT SGIGQQLTSL VQVRRIDHAD AMMVAPDQGY FVRENVKLRL
     LSARLALLSR NETTLKSDLQ AAQSALTRYF DASSKKTQNV VDLVKQVEAG SAAVELPNLN
     TSLQAVNQYR SRG
//