ID E1TJB1_BURSG Unreviewed; 455 AA.
AC E1TJB1;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN OrderedLocusNames=BC1003_3791 {ECO:0000313|EMBL:ADN59731.1};
OS Burkholderia sp. (strain CCGE1003).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia.
OX NCBI_TaxID=640512 {ECO:0000313|EMBL:ADN59731.1};
RN [1] {ECO:0000313|EMBL:ADN59731.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCGE1003 {ECO:0000313|EMBL:ADN59731.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA Pitluck S., Daligault H., Davenport K., Detter J.C., Han C., Tapia R.,
RA Land M., Hauser L., Jeffries C., Kyrpides N., Ivanova N., Ovchinnikova G.,
RA Martinez-Romero E., Rogel M.A., Auchtung J., Tiedje J.M., Woyke T.;
RT "Complete sequence of chromosome2 of Burkholderia sp. CCGE1003.";
RL Submitted (SEP-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IB topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00006645}.
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DR EMBL; CP002218; ADN59731.1; -; Genomic_DNA.
DR AlphaFoldDB; E1TJB1; -.
DR STRING; 640512.BC1003_3791; -.
DR KEGG; bgf:BC1003_3791; -.
DR eggNOG; COG3569; Bacteria.
DR HOGENOM; CLU_046978_0_0_4; -.
DR OrthoDB; 9778962at2; -.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00659; Topo_IB_C; 1.
DR Gene3D; 1.10.132.120; -; 1.
DR Gene3D; 3.30.66.10; DNA topoisomerase I domain; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR035447; DNA_topo_I_N_sf.
DR InterPro; IPR049331; Top1B_N_bact.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR Pfam; PF21338; Top1B_N_bact; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF55869; DNA topoisomerase I domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ADN59731.1};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 49..97
FT /note="DNA topoisomerase IB N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21338"
FT DOMAIN 110..323
FT /note="DNA topoisomerase I catalytic core eukaryotic-type"
FT /evidence="ECO:0000259|Pfam:PF01028"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 455 AA; 50107 MW; 421F0DCA63A98DCC CRC64;
MPTTNSTTPN AHAPADDAAK QAAATTMPPG LRHADDSKPG YTRKREKDGF AYFDVEGKRI
EDEAEIQRIN SLAIPPAYED VWICPDPRGH IQATGRDTRG RKQYRYHPRW RETRDADKYE
RMREFGRALP KIRARVARDL ELPGMPCDKV MAAVVRLLDT TLVRIGSVEY ARENQSYGLT
TLRKKHVKVE AGQVRFKFRG KSGIEHDVTV DDARVKRIVR RCAELPGHDL FQYLDDEGNR
RTVGSADIND YLRRASGADF TAKDYRTWAG SVYALATLRR LVCESAAEAR RHIVATVKEV
AGLLRNTPAV CRRCYIHPAV ISAFEADELQ SLPPGQSRRG LKVDEVAFAA LLAHAEKRAA
KLARQAGAKG RKLREAQEAD SINGSISTLL QKSRAIRKEA NKAALKAGAK TARQGRGKAA
AKAGVQDEAQ AGIKARARSS RRAAAGPGAD KPAAG
//
