ID E1VMB7_9GAMM Unreviewed; 1607 AA.
AC E1VMB7;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Alpha-2-macroglobulin family protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HDN1F_23760 {ECO:0000313|EMBL:CBL45959.1};
OS gamma proteobacterium HdN1.
OC Bacteria; Pseudomonadota; Gammaproteobacteria.
OX NCBI_TaxID=83406 {ECO:0000313|EMBL:CBL45959.1, ECO:0000313|Proteomes:UP000002677};
RN [1] {ECO:0000313|EMBL:CBL45959.1, ECO:0000313|Proteomes:UP000002677}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HdN1 {ECO:0000313|Proteomes:UP000002677};
RA Widdel F., Rabus R., Grundmann O., Werner I., Schreiber F., Ehrenreich P.,
RA Behrends A., Wilkes H., Kube M., Reinhardt R., Zedelius J.;
RT "Alkane degradation by a new type of denitrifying bacterium with possible
RT involvement of the electron acceptor in substrate activation.";
RL Environ. Microbiol. 0:0-0(2010).
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
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DR EMBL; FP929140; CBL45959.1; -; Genomic_DNA.
DR STRING; 83406.HDN1F_23760; -.
DR MEROPS; I39.008; -.
DR KEGG; gpb:HDN1F_23760; -.
DR eggNOG; COG2373; Bacteria.
DR HOGENOM; CLU_004561_0_0_6; -.
DR Proteomes; UP000002677; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF136; ALPHA-2-MACROGLOBULIN HOMOLOG-RELATED; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF01835; MG2; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002677};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 667..813
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 878..981
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1607 AA; 178074 MW; 6F1474E70F186425 CRC64;
MRNHIVIDNK EFLLKDGGID LWLILITAML ISLLPAFSYA NENIPDSNYQ AQQGEAFFLL
SDTTFSSDEI AKVRLEAPGR DHRRYSMESY GGVDIRVYRL ENPLEFLKKQ KNLHRILQEG
SLKGEGVANA LAYLWDNWYS KSRRVMQRAF SYQTRKEVTA EVPQLKMGDA IEAPTQYQSP
NVFAPLKGFP LVSEFRYPLW DAKPIQPPTE VKLSGSSSNF LETNPGNVYI PLGKLAPGLY
FVEAMVGRHR ATTTVFVSNT VAISKISGNE LFVWTVHRAQ QTPVAHAKVL WTDGLGILQR
GESDEDGTVR LLHKSPERSF VIGEDTEGGI FIAENFYYDS EVYDTRLYTF TDRPLYRPGD
RVSFKVLGRK FSASQTSVAA GSSPVDITVI DANGTTLQTL RANYDKENGA DGEFSLPENA
TAGGYELRVT YQGRVYSSAF RVAEYVKPHF EIAIHLDQPA FKSGEKIAGS LTLVYPDGSP
VKNANIELRL RAQALSMVDN DLRYLGEFPV ELETKDMRSN SEGKVALSLP AADRPSRYVL
TVFASDGAAY RVKTTREILI ERGANQYSIL GDRNFSKLNE SVTFSVHQQG IATVDAQQQI
PSRWEWQRLE DQTRAEGSVP ENGLHFQLSF NRPGTYVIHV RDQDGKLLGA THHSVSGAGI
VSAPGSVRIV LDKQEYQVGE TAEALVTFPE PVKDALFSLE RDHVEYAALL SRPAPWLSVE
RIDSAQYRLL IPVTAEFSPN ITLSALYVKG SEYAFQNAGI KVPTPKLDVS VRADKSVYAP
GDTVTVQIDT HLNGMPAPSQ LVVSVVDEMV YALQPEIAPS INDFFYRMRR NNVRTGASLS
FISYDVATPA SGEVPSRSYR NERGVKVLER PRREEIDTAA WLPRLQTDAE GHAQFQFVMP
DSLTRWRITV RAIRSVETAG PANATKLADG VTGQITRFIR SEKPLYLKWS GPKIFRRGDQ
PALGVLAFNQ GSQPLKAKML ARLGDQVQER SVDLPTGVSY QAFDQINASA GDLRVSIALD
QAPEQLLDQL DVSLSDQAAT WPEMRTLNIT LTEKETPIAL PANAFDVRMT LSNTTEQRYL
DALSDLLDYP WGCIEQTASR LLPLSLAYPF IQSQFSGLQL NESQLNDSQF NESRNNVEIA
GGSNELLVRL RSIMQGNRLR LVQMAGEDAT FSWWGEGTEP NALLTAYAYY ADWETSRALN
IPLSSDHARR VLELYAKQAS DMPPLHRALA LGFLYEMRQP VSSLLSGVVK DLLQDSKSSA
DQAADANTTQ DMAIQEVATQ AESSDTSLVF NAPDSPLGLA VTWALIAELS RRADITLPEQ
VSSAYENAAH LLASSTLPIA RGAAIRAGWG DAKDAALLFQ EMMPSQPTFE RALLLAWFKP
GATTTTDGAK ILPAVHPLQP WTIAPKHTTT STEWRWQGDP LPAHIVLSDV PPPTTVAVIR
YQGEGRTESP YPVNIQRKLW LLQRGEKESH YRAEPVTAAS DGTRLQSDAL YLDEITVSTT
ANQRLRYGLL EVSLPPGADV EPSVAGIKVA GLSDSGEVSL EKARSEPGQL SYAIPLEQLQ
GSVRVRHLVR FSQKGQFHLP PSRYYPMYAP ARQSFEESPA MSSIVVR
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