ID E1XT69_BPSAV Unreviewed; 346 AA.
AC E1XT69;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=Thymidylate synthase {ECO:0000313|EMBL:CBW37928.1};
GN Name=thyA {ECO:0000313|EMBL:CBW37928.1};
GN ORFNames=Vi01_060c {ECO:0000313|EMBL:CBW37928.1};
OS Salmonella phage ViI.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Ackermannviridae; Cvivirinae; Kuttervirus.
OX NCBI_TaxID=1987993 {ECO:0000313|EMBL:CBW37928.1, ECO:0000313|Proteomes:UP000000339};
OH NCBI_TaxID=90370; Salmonella typhi.
RN [1] {ECO:0000313|EMBL:CBW37928.1, ECO:0000313|Proteomes:UP000000339}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20817773; DOI=10.1128/JB.00659-10;
RA Pickard D., Toribio A.L., Petty N.K., van Tonder A., Yu L., Goulding D.,
RA Barrell B., Rance R., Harris D., Wetter M., Wain J., Choudhary J.,
RA Thomson N., Dougan G.;
RT "A conserved acetyl esterase domain targets diverse bacteriophages to the
RT Vi capsular receptor of Salmonella enterica serovar Typhi.";
RL J. Bacteriol. 192:5746-5754(2010).
CC -!- SIMILARITY: Belongs to the thymidylate synthase family.
CC {ECO:0000256|ARBA:ARBA00009972}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FQ312032; CBW37928.1; -; Genomic_DNA.
DR Proteomes; UP000000339; Segment.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000339};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 66..233
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
SQ SEQUENCE 346 AA; 38931 MW; 6207BA3D48BC25BA CRC64;
MEIFALNNND MLKKAVLAIR EHGIESDPGN AEINTDGTRF IDGVTITVSD PRDRWLSVEG
RNSSAIAAIG ETFWVLSGRN DIRFLSKVLP RAANFSDDGV TWRGAYGPRL YNNGQLDSVI
SRLRNNPNTR QAYLTIYDPA LDSDEGLAAH SETGEAKTKD MICNLALLFS ITEGRLNITV
INRSQDVLWG MSSINFIEFS ILQEVLAKVL NVEVGYYKLF SNNLHYYNNE VSRKQLGGIT
KKTKTSSGMY NSLLEFSSEK VKSQKDICNL FLGVLHHCDI GSDFGKIREH LKGYQADTGL
MMDMSYCLWC RLNDTKIDKR RIADDGLRTA LLHSPVDQKF MWGYGE
//
