ID E1Z318_CHLVA Unreviewed; 4500 AA.
AC E1Z318;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Dynein alpha chain, flagellar outer arm {ECO:0008006|Google:ProtNLM};
GN ORFNames=CHLNCDRAFT_133411 {ECO:0000313|EMBL:EFN60095.1};
OS Chlorella variabilis (Green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Trebouxiophyceae;
OC Chlorellales; Chlorellaceae; Chlorella clade; Chlorella.
OX NCBI_TaxID=554065 {ECO:0000313|Proteomes:UP000008141};
RN [1] {ECO:0000313|EMBL:EFN60095.1, ECO:0000313|Proteomes:UP000008141}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NC64A {ECO:0000313|EMBL:EFN60095.1,
RC ECO:0000313|Proteomes:UP000008141};
RX PubMed=20852019; DOI=10.1105/tpc.110.076406;
RA Blanc G., Duncan G., Agarkova I., Borodovsky M., Gurnon J., Kuo A.,
RA Lindquist E., Lucas S., Pangilinan J., Polle J., Salamov A., Terry A.,
RA Yamada T., Dunigan D.D., Grigoriev I.V., Claverie J.M., Van Etten J.L.;
RT "The Chlorella variabilis NC64A genome reveals adaptation to
RT photosymbiosis, coevolution with viruses, and cryptic sex.";
RL Plant Cell 22:2943-2955(2010).
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm, cytoskeleton, flagellum
CC axoneme {ECO:0000256|ARBA:ARBA00004611}.
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DR EMBL; GL433835; EFN60095.1; -; Genomic_DNA.
DR RefSeq; XP_005852197.1; XM_005852135.1.
DR STRING; 554065.E1Z318; -.
DR GeneID; 17359247; -.
DR KEGG; cvr:CHLNCDRAFT_133411; -.
DR eggNOG; KOG0379; Eukaryota.
DR eggNOG; KOG3595; Eukaryota.
DR InParanoid; E1Z318; -.
DR OMA; ITMDAHG; -.
DR OrthoDB; 312149at2759; -.
DR Proteomes; UP000008141; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00102; IPT; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF8; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 2.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF00630; Filamin; 1.
DR Pfam; PF13418; Kelch_4; 1.
DR Pfam; PF13854; Kelch_5; 1.
DR Pfam; PF12777; MT; 1.
DR Pfam; PF01833; TIG; 1.
DR SMART; SM00382; AAA; 4.
DR SMART; SM00557; IG_FLMN; 1.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 2.
DR SUPFAM; SSF117281; Kelch motif; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR PROSITE; PS50194; FILAMIN_REPEAT; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008141};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 305..392
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT REPEAT 392..502
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT DOMAIN 1621..1778
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1913..2074
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2263..2408
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2615..2801
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 3579..3615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3631..3653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4114..4143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3108..3163
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3455..3482
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 3595..3615
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4500 AA; 491866 MW; CCAA0F82A383CEF9 CRC64;
MLCWVACSGG SGPGASPAGP LPRCGHTFTT LANGDVHVLF GGAGRGTGTK ATYLADAHVA
RVAADGSVTW QAHKVRFNDC WILDVSAQRW ALAEVAGSPP TPRAHHTASK LGDKVFFFGG
YGGGGADLGD LWVLHLGGGG LRWEEVSASG PAPPPRFDHT ATLVATAANS PSPDKLLILG
GRDSTQNFTD AHVLDLESMA WEQAHGMPAL GGEICNHLCS SVESVPYHKV FAGFGKCDTL
QYGNTMQWSV PETAGPELPL GREETAWVWD AKSFSLVLFG GWANRWLGDT WRADVSTIIG
PGYACLGIAP AIGPVAGGTE VTITGLRFRD GQIRVKLISP RGENIVEGTF VSREAVRFKT
PAHEQHGALL CNVYVSIGSD NWTVNQLKFQ YFSNMLPSAS LAYGPGVLPQ VHCGIEMPFL
LVSKDTTNHK RTSGGDGFEI AVESESGAVV GSSRIVDRGT GTYECFYRAP APGRYKIHVR
GAGTGGEGGM AHIRGSPFSV EAADPWQQRG LVGVAPAKRA AATLSSVGTD LVLFGGDKSL
AAVCHAPGGE EPWQWFPTSE ADRATARKGH AAAGVAGTKQ LVVCGGQALE GEPADLADVR
LLVSNGSSFA GTSWHWQPAS AAVQLHQWTD GTEVPTERNS HCAVAFGSTL LVFGGEHQGQ
LLQELCLLDL SSKGAAAAAA GDGFVAIFGG CASNEQGEDV LLNDLHLVQV ESLSRVRCGQ
QEASGAAPPP RAGAILQEYG SGRLLLYGGT GAGGRPLGDA WVLDVAAQTW ECLYDGEPQT
PLVALHGGQL VSLASAPGSS RLDVVRSLNL EHAAESVSFL AKMRPEVASA AKDLEAWVAK
QQTGLDLAAK ADSTETLLKA GCRLPGCWLP SPQVMDALYL VRSKRRDTDL LFDQLKESCQ
LLAGEHRVKD AARTDRQLDD LRHRWEAVKK AAPQVRASIK AAQEAECERV KADMERFSAA
VAQYVGSIYS KRAFFAWATG VEAAFSDIEK TFKDLEAMHA EHSRLHTLGK LFDCSQLLEA
AAASIKATDE ELAALRALWQ QAAAAEKKLG DWNQTLFSAV DVAALEEGAK ALVKEVKALP
AAVREQDCFR GLEVLVKNYL ASVPLIGDLR SPAMRPRHWQ ALQEATKVHF EVGEEFRVED
LLRLQLHKYA EDVAEIVDRA QKEEKMETAL AKLQDTWSKV CFVFQPHRGS SEVSTVKMAE
DDFAALEDNQ VLGMMASRFV ATFRDDVLAW NKKLNAVADV VQLMAEIQRS WAYLESLFIQ
SEEVRRELPE ATQRFAGIDA AVRAVLLDMV VAKNCVACCT KEGLLRHLEA QQGELELCEK
ALADFMESKR RAFPRFYFVS SSDLLEILSN GNKPASIMPH MAKIFQAGCK LPAGGPDTEQ
QPTLTHPPFF LAINALRLDT DKPAAGVRPK ALGMESCVGV EYVAFQTPLA LEGKVEAYMG
RVVDKMRAEL RAVMGDSVRD YPAKPREKWM FDWPSQVALM VNQMYWCQEV EEAFGQLAGG
NKNAMKAYNE RQVAQLTRLI EITCTELSKA DRQKVMNHIT IDAHSRDVVQ HIVETGAADR
DCFAWQSQLR TYWDSSIGDC RVRICDASFP YGHEYLGNGP RLVITPLTDR IYVTATQAMW
LSLGTAPAGP AGTGKTETTK DLAAQLGLAC YVFNCAPEMD YHTLGNIFKG LAALVPEVLS
VCSVQYKCVT DAQRRKAALP GRGLEYVDAQ GVKHPAVQGF TFVAADGVEM PLEEGTSVFI
TMNPGYIGRA ELPESLKALF RPITVVVPDR QLIMENMLMA EGFVTAKALA KKFAALYYLL
EDLLSPQKHY DWGLRAIKSV LVVAGGLLRS QAGQDETDVL FRALRDFNLP KILAQDLVVF
NGLLADIFPQ TNPPRQRDPG FEAVVKQTAR ELGLEPDEEF VHNVVALSEL LAIRHCVFLM
GPTGCGRSEV IRVLAKAISA GCDAPSNPYL QANNRKKVVV RDLNPKSIST QELYGYVNMA
TREWKDGLLS CTLRELANVP DDNPKWIVLD GDLDANWIES ANSLMDDNKL LTLPSNERIR
LLPHMKLIFE IRDLRYATPA TATRAGILYI SEGRQWSSLV ESWLRRVSRA YAEKAKWGDA
EVPLRWLQEL FGKYVPPTAF EMRKSFSHVV PLGTMNFVGT LCSILEGLLR PENLPAKAEQ
PLFEMAFVFA CVWAFGGALC EKDGIKYRQA FDKWWKATWT AVRFPQKGTV YDYYPNFKSA
KFSPWADLVQ PVEYDGSVPM SQVFVPTPET VSLRFFLDMM LSLRKPIMFV GGSGVGKTQL
VKGKLQALGE DQSALSISMN YFTDVASFQK ILESQLEKKA GANYAPPANR QQIYFVDDLN
MPRLDAYETA MPISLMRQHL GYGHWYDRAK LTLKAVSGTQ YVACMNPTAG SFVVDPRLQR
LFVTLAVETP GVDSLMMIYG SFLHGHLKKF SQDVQELGNK LLQAALALHE KVVSTFRKTA
VNFHYEFTVR HLAQIFQGLM MSTPDKYNSD PSKLIRLWLH ESERTYADRL VSAADLAQFG
KLVVAVAKKY FSLPDIDDYY RAKDPKPLVF CHFAAGHGGD ACYNEVVDAA GWKRLQRTLA
EGLAEYNETN AVMDLVLFDD AIRHVCRISR IISSPGGHAL LVGVGGSGKQ SLARLAAHMC
GYTCDTIIIS GTYTLASFRE DLVRMYKRAG LKDEGVLFLL TDSQIVDEKM DRKDVIPTLR
NEVKGRGLAK TNENWWGLVY VNDLLSSGDI PDLFAPEDRE DVIAAMRSEV KARGLPDTND
NCWRVFIQRV VKNLHVCFTC SPVGDAFRVR SQRFLATVNS TTIDWFHPWP EASLLSVARK
NLEDLEVESE DVRKAVVEFM PASFAAVGAM AKQYLRAERR RVYSTPKTFL ELIKLYRSLL
AAKRQAVQAS TERLQVGLAK LTKTQKDVDV LVEQARVMAV EVEQKVAAAS RFAEEVGVEK
EKVNAENAAA QVEADACATI AREVTELQAR CESELAAAEP LVAQAQEALD TLTKKDLGEL
KALRNPPAGV DDITAVVLCL LENVPKDRSW GAASKMMNNV DAFLARLKGF KPTIDAGEVP
QKNVDACRSY LELPHFNKEA MSNKSKAAAG LCSWAINIVR YYDVWSTVEP KRQELAQANA
KLVEANEKLV AVRAKVEALN AQLQALEQQY AAAAAEQDAA LAQSEACQRK LDLANRLITA
LASEGGRWAS TVEQLRGDYR VLTGDMLLAA AFITYAGPFS SKFRELLVAD WLKFLHERGV
PMSPGLSDPL KRLVDDAMVA GWVREGLPAD PTSVQNGAIL TNSERWPLML DPQLQGVAWV
KERLAKQGLV CLRMGAPDML RAMERAISEG QTVLFENIGE SIDAVLTPVI TRATFKKASH
TEVEYNKAFR CILHTKLSNP HYAPEAETTL INFTVTEGGL EDQLLALVVN KERADLEEAK
SQLIVQNSEF VIKLQQLEDG LLEKLSTAQG DLTENEALIV QLEESKALAD EISEKVVEAR
ETEIQINEAR NVYRGVASRG SMLFFMLNSL GRMHAFYQYS LQAFVDVFER GIDAAPGGRR
KAVLAASAQQ HHVTLADLAR RQTQQPGNFD AVMELARRST MGGGRGERGI SLQGSRLELP
QNESSTGSAR QSVVGESTLK HARERLTHMG QSCPRRTTHQ HHHGGRGSVL GGALEDEPAE
LTPEQLEARL EALLQACTYT VFSYTQRGLF DRDKLTFTSL LTTQILLKNG TIDGKELEHL
CRWPRAATPP PMSEELSQWM SEGQWAALAP LAQQLPAFGG LLKDLEKNGE EWEKWAAGDA
PESVPMPGEW CKLSDFRRLL VLRALKPDRL PAALGALCER AMGAAYVNQE PFSARALLAE
STHATPIFFI LFPGYSPGAR IEAYARTVGH TSERGNFTLI SLGQGQEGPA ERALDKCMRE
GGWVFLENTH LMASWIPTLE RKLEAAADTA HSDFRCFFSA EPIAGAPHAA ILPESLLQAR
AGGGTAIRVS NEPPSDIRSN MRRAWAAFPP DFFLRASTEP KRAALRSIIF GLCFFHSVLL
GRKKFGTGIG SAGGGGGLGY CRAYSFNTGD LATCGDVILN YVEGKATVPW QDLRYLLGDV
FYGGHVVDDY DRRLLNTYLQ KLFTQELLPV GPGASDGHQA AMDGAATDQP ADGAGQPPLE
LAPGWRPPPA VDYESMTQYI ETSCPADSPA LYAMHGNTQL SLLNSQTEAL FQTILDVGGL
GAAASAAAAA AAAGGAAAGG EAAVRASLAD LLGRLPAPLG LVDIEARVKE KTPFVVEAER
MNGLLGEMRR SLEELQLGLD GALNMSPAME QLGAALGAGR VPPSWMACMS TRVQEVYALP
AWYADVLQRH AQLVGWTGGA VSPPRSIWLP GLFNPKACLT AVMQQFARQR RLPLDDVRFV
VEVTGKQPEA LSEAAPDGGM YIHGLTLEGA RWDAQDDCLR DSLPNQLRQA LPVLLVRPLT
AQAHQAALAA GNLYLCPVYA NGQRANVYSP LVSTFTLKTR EPPSKWVLAS TTLLLQDELA
//
