ID E1ZAE1_CHLVA Unreviewed; 598 AA.
AC E1ZAE1;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0000259|PROSITE:PS50850};
GN ORFNames=CHLNCDRAFT_143760 {ECO:0000313|EMBL:EFN57045.1};
OS Chlorella variabilis (Green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Trebouxiophyceae;
OC Chlorellales; Chlorellaceae; Chlorella clade; Chlorella.
OX NCBI_TaxID=554065 {ECO:0000313|Proteomes:UP000008141};
RN [1] {ECO:0000313|EMBL:EFN57045.1, ECO:0000313|Proteomes:UP000008141}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NC64A {ECO:0000313|EMBL:EFN57045.1,
RC ECO:0000313|Proteomes:UP000008141};
RX PubMed=20852019; DOI=10.1105/tpc.110.076406;
RA Blanc G., Duncan G., Agarkova I., Borodovsky M., Gurnon J., Kuo A.,
RA Lindquist E., Lucas S., Pangilinan J., Polle J., Salamov A., Terry A.,
RA Yamada T., Dunigan D.D., Grigoriev I.V., Claverie J.M., Van Etten J.L.;
RT "The Chlorella variabilis NC64A genome reveals adaptation to
RT photosymbiosis, coevolution with viruses, and cryptic sex.";
RL Plant Cell 22:2943-2955(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. MFSD6 family.
CC {ECO:0000256|ARBA:ARBA00005241}.
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DR EMBL; GL433840; EFN57045.1; -; Genomic_DNA.
DR RefSeq; XP_005849147.1; XM_005849085.1.
DR AlphaFoldDB; E1ZAE1; -.
DR GeneID; 17356745; -.
DR KEGG; cvr:CHLNCDRAFT_143760; -.
DR eggNOG; KOG3762; Eukaryota.
DR InParanoid; E1ZAE1; -.
DR OMA; WGSISNG; -.
DR OrthoDB; 325157at2759; -.
DR Proteomes; UP000008141; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR024989; MFS_assoc_dom.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR16172:SF41; MFS_1_LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR16172; UNCHARACTERIZED; 1.
DR Pfam; PF12832; MFS_1_like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008141};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 72..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 512..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 379..598
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 224..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 598 AA; 61624 MW; E17DFE115CD2F696 CRC64;
MRIPQGEEWL GLGPFRTVLV PKVYFFTVSA GLVFLLPFVN VFYREIGFSE ELIGVLCSLI
VSAADASRRH MAVLLAVYLT AFIGRSFITF FTAFSVQLAL ALLTEAAASP MGALVDAAVM
ASATDEGGYG RIRMYASVGW GLTAPLAGWV VAAFGLRAAF LCYTFLVGAC LPLAALMPME
VLAAPKAAAQ AAPAAGDAGS QLCCQGASFE QLGLGSDGAG TRSDAENFSV HVSGGSEGQL
PHLATKEGSR HGCDGSAKRW SIGTALHAAP EPHHTQDPGS SPRPVIHLVA DARGGGARLL
SSPERPLLSP SSCPSSPDAP AIDRTWHTTT TTTCSTSTLE IAAGPSKARL AGPAGGPGPA
GGAPTSVWRG VRALLGDVHV AVFFFLAFLM GVGNGVIGYL FLYLDELGAS GTLMGLCLSS
NCAAEVPVFF FSGRLLARLG VERALHLAMA AYVARLLAYL ALPLLPSAWL VLPVELLQGC
TFALAWSAGT VQVKRIAPPH LRSTVQSLFQ GLYTGIGAGL GGLVGGLLYG SLGASALFRT
AALALAAGWL GALAVLRVWG GSSGGYAAQQ VQQSAEGQGQ LERQASGEEG EAAALLRP
//
