ID E1ZE83_CHLVA Unreviewed; 535 AA.
AC E1ZE83;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=MLO-like protein {ECO:0000256|RuleBase:RU280816};
GN Name=MLO {ECO:0000256|RuleBase:RU280816};
GN ORFNames=CHLNCDRAFT_145348 {ECO:0000313|EMBL:EFN55984.1};
OS Chlorella variabilis (Green alga).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Trebouxiophyceae;
OC Chlorellales; Chlorellaceae; Chlorella clade; Chlorella.
OX NCBI_TaxID=554065 {ECO:0000313|Proteomes:UP000008141};
RN [1] {ECO:0000313|EMBL:EFN55984.1, ECO:0000313|Proteomes:UP000008141}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NC64A {ECO:0000313|EMBL:EFN55984.1,
RC ECO:0000313|Proteomes:UP000008141};
RX PubMed=20852019; DOI=10.1105/tpc.110.076406;
RA Blanc G., Duncan G., Agarkova I., Borodovsky M., Gurnon J., Kuo A.,
RA Lindquist E., Lucas S., Pangilinan J., Polle J., Salamov A., Terry A.,
RA Yamada T., Dunigan D.D., Grigoriev I.V., Claverie J.M., Van Etten J.L.;
RT "The Chlorella variabilis NC64A genome reveals adaptation to
RT photosymbiosis, coevolution with viruses, and cryptic sex.";
RL Plant Cell 22:2943-2955(2010).
CC -!- FUNCTION: May be involved in modulation of pathogen defense and leaf
CC cell death. {ECO:0000256|RuleBase:RU280816}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU280816}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU280816}.
CC -!- DOMAIN: The C-terminus contains a calmodulin-binding domain, which
CC binds calmodulin in a calcium-dependent fashion.
CC {ECO:0000256|RuleBase:RU280816}.
CC -!- SIMILARITY: Belongs to the MLO family. {ECO:0000256|ARBA:ARBA00006574,
CC ECO:0000256|RuleBase:RU280816}.
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DR EMBL; GL433843; EFN55984.1; -; Genomic_DNA.
DR RefSeq; XP_005848086.1; XM_005848024.1.
DR AlphaFoldDB; E1ZE83; -.
DR STRING; 554065.E1ZE83; -.
DR GeneID; 17355402; -.
DR KEGG; cvr:CHLNCDRAFT_145348; -.
DR eggNOG; ENOG502QPZ5; Eukaryota.
DR InParanoid; E1ZE83; -.
DR OMA; NTHGWYT; -.
DR OrthoDB; 297199at2759; -.
DR Proteomes; UP000008141; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR InterPro; IPR004326; Mlo.
DR PANTHER; PTHR31942; MLO-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR31942:SF77; MLO-LIKE PROTEIN 14; 1.
DR Pfam; PF03094; Mlo; 2.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|RuleBase:RU280816};
KW Membrane {ECO:0000256|RuleBase:RU280816, ECO:0000256|SAM:Phobius};
KW Pathogenesis-related protein {ECO:0000256|ARBA:ARBA00023265,
KW ECO:0000256|RuleBase:RU280816};
KW Plant defense {ECO:0000256|RuleBase:RU280816};
KW Reference proteome {ECO:0000313|Proteomes:UP000008141};
KW Transmembrane {ECO:0000256|RuleBase:RU280816, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280816,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 53..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 471..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 535 AA; 59286 MW; EF635D4DB1FF7BDC CRC64;
MSELPGWRIG IIFIIFFTVA FAWDAGTAAL EGWLKRHHKR GLRHVLQRLQ RELLVLGLLS
LLLIAFEGYL LKICIPCGTS CSWDCPAQQG SDAGSGSDGG HRRQLLASAA LDELSCRQAA
DTCGPGSEPF WSQLALIQAH VFLFTIAAVH ICYACVSMLL CLWKLRRWHR FEQHALQHEL
RPMSLRSLPR PGDNALTHFL WCIASMLTGG VNAEVYLGLR RLFVERLDVD PSFDFWSFLV
ESMEEEFSQV VGVNIVLWLL LLVWIMLPGA SYQMIWLSSL AVAAVFLVGI KLQSIIICLA
QGAYQLYGSR SADESAPAQQ EAQRPQLDAW PQVPQRERQQ QLERQYRGPD AASLFWFGKP
RLVLRTIQLV YFENSLSIAA VLFSVWQGVD FDWSRYGGWP FLVSMIVIEH ALKKNIKPDM
ARQVGMLALQ RMSAEPRWSP EPGEHVPDST GNAEQLAEAA DAGVYDVSTR PAGASSMQQL
EQEGGSELSG QQPDRGSSQA GVGLAAFAAG GSAAVLDISD ADDERLSITR LMESG
//
