ID E1ZWI3_CAMFO Unreviewed; 1015 AA.
AC E1ZWI3;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Rho guanine nucleotide exchange factor 7 {ECO:0000313|EMBL:EFN74420.1};
GN ORFNames=EAG_08874 {ECO:0000313|EMBL:EFN74420.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421 {ECO:0000313|Proteomes:UP000000311};
RN [1] {ECO:0000313|EMBL:EFN74420.1, ECO:0000313|Proteomes:UP000000311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C129 {ECO:0000313|Proteomes:UP000000311};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}.
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DR EMBL; GL434853; EFN74420.1; -; Genomic_DNA.
DR AlphaFoldDB; E1ZWI3; -.
DR STRING; 104421.E1ZWI3; -.
DR InParanoid; E1ZWI3; -.
DR OMA; KSIHTTY; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01225; PH_Cool_Pix; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11877; SH3_PIX; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR046376; PH_Cool_Pix.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR PANTHER; PTHR46026:SF1; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000000311};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 5..64
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 90..269
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 291..393
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 65..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 971..998
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 72..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1015 AA; 115182 MW; E968737517256466 CRC64;
MSKPDAPKFV IALFSFKGKN NDELCFKKGD IITITQVDDE GWWEGTLHDK TGWFPSNYVK
EYRIPDGGHT SIKTSPERSP QESPAQQKLN RDIVLKDIVD SERVNVAELQ GLVNNFLQPL
EASNILKKDE YKQLLGNIHE ILETHHSLLA NLEATILQGL SARVGNLFLT IAPRLKSIHT
TYCNNHPQAV CILDRYRDEL NEFMERSGAI SPGILVLTTG LSKPFRRLDK YSAMLQELER
YTEKNHPDRG DTQRSIAVYR EITDHCASIR KQRELALQIL TSGIKGWEGE ELSSLGEIIY
VGSVTLATVD RRDRYFVLFP TTLLVLSTSP RMSSFIYEGK LPLTGINVTG IEDTDEIRNA
LEITGPMIES IVVLCATREE RQRWIDLLIQ EQGTSSLLKS PTVSRVSCHH PPYARLSRYF
AKLVRRKVIY PELMKKLLYM QYILKPDLSD VKMRKCNVTY IILTARSSEE SESNTSIESN
IQEEPRILRK SSLILDVRYV IDNTDLSMVG LANTSSLTNF ASRVDRSTFE TSKSLPADAT
MSHVLPLASS KSYTSKFHTR CNDFCREHLE IPHDQEHSGL TMNYSKTIEL YPKMSEIQYS
TTSTEKNSIK KETCANTSLQ SSDSGMAESY RLNSSEINSC YKSYASSHTK YTDPVRTSHS
ESDNDENKFE HQCICTSPFG STPRDSAHSL ASSKNIDECT SLAKPSDNDV NNDSNNSEKK
IQEISLLTHP LLNYGNVQGK RYTQPIPYAH QCVIKKVGRH VVRPIQPIME EHEPTNQVYS
SGLYAHWWLK KPIPIFGNTE QGKLPWHGCF FDHFSFLTIA GVFTNYHFSS KIVCPYFTAM
LCEQVNNQLN GKHQRPIMEH CTSPGIKTPW SLASLRPAPP LYSLKSFGKI DTTDTSRLQR
SCNERQFEED AIILKVIESY CLSVNARFTV HSGESNSMLD YDSQKSRDRT SYAHNKGIWE
SCNDRTLSET VKTLKNQMTD LQSQMSLLTK QLDEERRSRL SLAATVKRSM GVIDG
//
