ID E2A801_CAMFO Unreviewed; 1179 AA.
AC E2A801;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=EAG_08733 {ECO:0000313|EMBL:EFN70438.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421 {ECO:0000313|Proteomes:UP000000311};
RN [1] {ECO:0000313|EMBL:EFN70438.1, ECO:0000313|Proteomes:UP000000311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C129 {ECO:0000313|Proteomes:UP000000311};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; GL437468; EFN70438.1; -; Genomic_DNA.
DR RefSeq; XP_011253194.1; XM_011254892.2.
DR AlphaFoldDB; E2A801; -.
DR STRING; 104421.E2A801; -.
DR EnsemblMetazoa; XM_011254892.3; XP_011253194.1; LOC105249432.
DR GeneID; 105249432; -.
DR KEGG; cfo:105249432; -.
DR InParanoid; E2A801; -.
DR OMA; HYKNTNL; -.
DR OrthoDB; 103262at2759; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 2.60.40.1110; -; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR014020; Tensin_C2-dom.
DR InterPro; IPR029023; Tensin_phosphatase.
DR PANTHER; PTHR22967:SF57; AUXILIN, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR22967; SERINE/THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF10409; PTEN_C2; 1.
DR SMART; SM00271; DnaJ; 1.
DR SMART; SM01326; PTEN_C2; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51182; C2_TENSIN; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS51181; PPASE_TENSIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EFN70438.1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000311};
KW Transferase {ECO:0000313|EMBL:EFN70438.1}.
FT DOMAIN 34..309
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 413..588
FT /note="Phosphatase tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51181"
FT DOMAIN 592..728
FT /note="C2 tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51182"
FT DOMAIN 1113..1179
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT REGION 313..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 765..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 818..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1041
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..345
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..374
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..789
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 982..1029
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1179 AA; 129412 MW; FBD79A8E543FDE66 CRC64;
MSDYLRSAFG YLNGGSGGGN EYVGQTLDIN NVRLRVTRLI AEGGWALVFA VEDITTGKEY
ALKKLIAVDE DTNKTIIQEI ETLKKLSGHP NIIQFFYAQR LEREDRKGYE YLVVTELCPG
GTIADILRNV SANTLTLAQV CKVAYQATQA VHYMHSQQPE PFVHRDIKLE NFLIGKDGLV
KLCDFGSAST QQILPNPSWN AQKRATLEDQ MAKYTTPMYR APEMMDTWNN EPIGPPVDCW
ALGCILYSLI TLRHPFPEGN KLAIVNGKYP PLPPNPRYAC LNDLVKGCLQ VSPIQRSTTA
QLLERLAAIA ESNNFDPREP PQIEVTAVRP SPPPRPTPPP PPSSSSSSSS SSNMPPPRPS
QPATMPPPRP APMQVSKIPA TQATTGLFNS LRGGAGSILR NLKDTSSKVM HTVQQSMART
ELDASYMTSR MLVMPYPADG IESAYRANHV EDVRAFLQAR HPPPAKIQLY NLSRGRPNVT
RLPGRHIDCS FAYATPESNA PMLFALYQIC QDIYQYLNAD FNHVVVLYCT DGYRASATVA
CTLLIHCRAL TTAEEAIALF TTRRCQPPQL QPSELRSINY MSLLSSGRLP HTKPLVFRSV
VIQPVPLFTR ARDGCRPYIE IYSNGALVFT TKKVIYEEMK LFGMMEGKVC LILGDAAVRG
DVTIIIHHAR QQLGRVIGIK IASLHFHTGY VPITESALTF EKHDLDDAPE IGGKFRIVLN
VMIGEENSKL SRVPAPWEAE TCINLVPDPL FGSTLEMEET LENFRTAPHP EEIQAPSNET
DNNMKQHEAI PQQPEDLKEE EEANTNEEIN FQEADLLNLG MPDNTNSTSN TPASTAPNPG
LDIFSSSSQN ENDLLGGFGM SAPHTETANS PLINNSASAD LLFGHDSSAT RNNSTANNNL
NMNDLLFGQN QTMSSNVKQV NEMLFDPLGG SSANNLLGGF AAAKSPNAED NLPRNASVPN
FAAQANKDPF ANLASSLGAG LTGSWNGTPR NSSTPQSASP APASTPIHSS PNTIHRSNDA
NSANSGNTDA LGAKAKEKAS GDAFEDLLGS QGYKFSRKAE KDSPKTINQM RKVEAAKTMD
PDRLKIAEWT EGKKGNLRAL LCTLHTVLWP EADRWQRCEM HQLVTSADVK KAYRKACLVV
HPDKQTGTAN ENIAKLIFME LNNAWSTFDN DPSQQNLFS
//
