ID E2A8L7_CAMFO Unreviewed; 712 AA.
AC E2A8L7;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
DE Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
DE Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
DE AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
GN ORFNames=EAG_14007 {ECO:0000313|EMBL:EFN70204.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421 {ECO:0000313|Proteomes:UP000000311};
RN [1] {ECO:0000313|EMBL:EFN70204.1, ECO:0000313|Proteomes:UP000000311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C129 {ECO:0000313|Proteomes:UP000000311};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
CC Nucleus {ECO:0000256|RuleBase:RU361195}.
CC -!- SIMILARITY: Belongs to the dwarfin/SMAD family.
CC {ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}.
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DR EMBL; GL437652; EFN70204.1; -; Genomic_DNA.
DR AlphaFoldDB; E2A8L7; -.
DR STRING; 104421.E2A8L7; -.
DR InParanoid; E2A8L7; -.
DR OMA; NIAYFEL; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009791; P:post-embryonic development; IEA:UniProt.
DR GO; GO:0050793; P:regulation of developmental process; IEA:UniProt.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0051239; P:regulation of multicellular organismal process; IEA:UniProt.
DR CDD; cd10492; MH1_SMAD_4; 1.
DR CDD; cd10498; MH2_SMAD_4; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 3.90.520.10; SMAD MH1 domain; 1.
DR InterPro; IPR013790; Dwarfin.
DR InterPro; IPR003619; MAD_homology1_Dwarfin-type.
DR InterPro; IPR013019; MAD_homology_MH1.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR001132; SMAD_dom_Dwarfin-type.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036578; SMAD_MH1_sf.
DR PANTHER; PTHR13703:SF45; MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG; 1.
DR PANTHER; PTHR13703; SMAD; 1.
DR Pfam; PF03165; MH1; 1.
DR Pfam; PF03166; MH2; 1.
DR SMART; SM00523; DWA; 1.
DR SMART; SM00524; DWB; 1.
DR SUPFAM; SSF56366; SMAD MH1 domain; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS51075; MH1; 1.
DR PROSITE; PS51076; MH2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|RuleBase:RU361195};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361195};
KW Reference proteome {ECO:0000313|Proteomes:UP000000311};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361195};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361195}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 42..166
FT /note="MH1"
FT /evidence="ECO:0000259|PROSITE:PS51075"
FT DOMAIN 488..712
FT /note="MH2"
FT /evidence="ECO:0000259|PROSITE:PS51076"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 61..88
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 262..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 712 AA; 76359 MW; 39B2A359CBE35579 CRC64;
MVGLAGGGGH LYPSPPMQPN PELREMTGIA PSAPTSADAC LSIVHSLMCH RQGGESESFS
KRAIESLVKK LKEKRDELDS LITAITTNGA HPSKCVTIQR TLDGRLQVAG RKGFPHVIYA
RIWRWPDLHK NELKHVKYCQ FAFDLKCDSV CVNPYHYERV VSPGIGLVNE FTEMLEKLRN
AREQIIDYCG LLDVLMEWVG FPRTDPFFTD LSGLTLQSGV GVGPGGRLVK DEYTVGGGGT
AAAAAAAAVG SAMDVDGEMN QTIQHHPPTP QSTASNNAQQ AQQGFIPGLS TPNPTSTEGM
FNAGGSGNNG NPHAKLDDNN CPRQTWIPTS HHSAGRNMHH PVVHPMSHTV GSQQQSLNAA
SSGTSGAQIL SPAQGQSTAD TFYGTNTPPQ DINQPPTVDA LAASLGEGQS SPVSPVHLHH
PNGFPVGTAP YNSGTPQWTG ANTLTYTQSM QPPDPRHLHT ASYWGGHGND VGGNIGGLLS
TQPAPEYWCS VGYFELDIQV GETFKVSSSC PTVTVDGYVD PSGGNRFCLG ALSNVHRTEQ
SERARLHIGK GVVLDLRGEG DVWLKCQSEH SVFVQSYYLD REAGRAPGDA VHKIYPSAYI
KVFDLRQCHK QMRGQAATAQ AAAAAQAAAV AGHLTHGGPI AKSISAAAGI GVDDLRRLCI
LRLSFVKGWG PDYPRQSIKE TPCWIEVHLH RALQLLDEVL HTMPIDGPRA IE
//
