ID E2ALX5_CAMFO Unreviewed; 1019 AA.
AC E2ALX5;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Very low-density lipoprotein receptor {ECO:0000313|EMBL:EFN65567.1};
GN ORFNames=EAG_00992 {ECO:0000313|EMBL:EFN65567.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421 {ECO:0000313|Proteomes:UP000000311};
RN [1] {ECO:0000313|EMBL:EFN65567.1, ECO:0000313|Proteomes:UP000000311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C129 {ECO:0000313|Proteomes:UP000000311};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; GL440682; EFN65567.1; -; Genomic_DNA.
DR AlphaFoldDB; E2ALX5; -.
DR STRING; 104421.E2ALX5; -.
DR InParanoid; E2ALX5; -.
DR OMA; DEYACKN; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 9.
DR Gene3D; 4.10.1220.10; EGF-type module; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 8.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF8; VERY LOW-DENSITY LIPOPROTEIN RECEPTOR; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 9.
DR Pfam; PF00058; Ldl_recept_b; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 9.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 9.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 5.
DR PROSITE; PS50068; LDLRA_2; 9.
DR PROSITE; PS51120; LDLRB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:EFN65567.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:EFN65567.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000311};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 938..962
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 514..528
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 616..659
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 660..702
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 703..746
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 747..791
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 1000..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 61..73
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 68..86
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 162..174
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 169..187
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 203..215
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 210..228
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 222..237
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 264..279
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 283..295
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 290..308
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 302..317
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 330..348
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 342..357
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 369..381
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 430..445
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 460..478
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1019 AA; 113485 MW; 1B78219CCADD5060 CRC64;
MLHTGWWWCA LTQWWNEGRK DTTVRRKRVV MGQDSRGVLL LVALAALAAA DAFSIDSKVA
CPLRQFRCAN GRCIPISWVC DKSDDCTDNS DESPEECKYT NCCLIISNSI EINQLICVTE
TVPAKSRDIG RNSVSSQLAC ATIIPIGAVA HSSMNISDAQ ECKDSDFKCT NGRCIPNIWH
CDGDRDCPDG VDEDPAVCRA IPCSETEFQC SPGECIPKTW LCDHQADCTD GLDEKNCHRS
KSCTPEQFTC HSGNGECVAL TWMCDDNPDC SDGSDEAECN DTCRSDEFTC ANKHCIQQLW
VCDNDNDCGD NSDEKACEPT ACHPNTDFAC SEHYCITSRW RCDGDYDCPD RSDEIGCKEP
PNKERISHCD KEFDCDDGVT CIHQTWVCDG EKDCPNGADE SSQRCHNVTC RPDQFQCEDR
RSCISGYLYC NGKAECADES DEKNCTSKGI SCDRRIQFEC SEGSCISLEY VCNQKPDCIG
WEDESADLCG VNECAKNNGG CSQICVDMPI GYRCDCHAGY RLIDNRTCDD IDECLEPGSC
SQFCQNEKGS FKCSCAAGYL KDPRNSTRCK AAEGHASLLF ARRHDIRKVA LDRQEMTAIV
NNTKMATALD FVFRTGMIFW SDISEKKIYK APIDEGNERT VVIEKDLTTS DGLAVDWIYS
HIYWTDSGKD TIELANFEGN MRKTLIQDHI QEPRAIALNP LEGWMFWTDW SDEARIERAG
MDGTHRSVIV GNDVKWPNGL TLDLIGKRVY WVDAKLNIIG SCNYDGTGRR TVLYSPSNLR
HPFSITTFED YVYWTDWDKE TIFKANKFTG KEVEAVTSIK TLQHPMVVHV YHPYRQPDGM
NQCQAVNGHC SHLCLPAPKI NSRSPLLSCA CPDGLRLLPD GLMCVENVTT TVAPSTEAAM
LPFQRLKPLN VTTTLNPLSA ADADGKRNLA TESTDPGLVA GIVIGVVSLG LLLLALVAVL
CYRHYLHRNV TSMNFDNPVY RKTTEDQFSL EKNRFPLPAA TVGEEAQEPL TSPGTNDYV
//
