ID E2AP45_CAMFO Unreviewed; 4072 AA.
AC E2AP45;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Dynein heavy chain 3, axonemal {ECO:0000313|EMBL:EFN64781.1};
GN ORFNames=EAG_03898 {ECO:0000313|EMBL:EFN64781.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421 {ECO:0000313|Proteomes:UP000000311};
RN [1] {ECO:0000313|EMBL:EFN64781.1, ECO:0000313|Proteomes:UP000000311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C129 {ECO:0000313|Proteomes:UP000000311};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL441452; EFN64781.1; -; Genomic_DNA.
DR RefSeq; XP_011261481.1; XM_011263179.2.
DR STRING; 104421.E2AP45; -.
DR EnsemblMetazoa; XM_011263179.3; XP_011261481.1; LOC105254483.
DR GeneID; 105254483; -.
DR KEGG; cfo:105254483; -.
DR InParanoid; E2AP45; -.
DR OMA; FFQSCAK; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000311}.
FT DOMAIN 1388..1525
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2016..2163
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 783..810
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2861..2923
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4072 AA; 469712 MW; 51D9A3F62A0622D4 CRC64;
MAEEKKTCGT LDKLNTVAQR MDYLLPETSK AFQFEEKPKL IQESSWTKTV PYKHWHNYVK
PTNSIGSIFT PSVCHRARIL TKRKIKPAQW YPLSADKILA TPPRILIERH NKEIQQRVAA
AEKKCDSLPE NIISLKDLAD GTWLQKKSRK ARALKRKELY IHKGRIMKKK LDREIVPYVE
AEIPKSVEEQ LTELTVAIDK EQTRTTTEDV AKVVYLRDYC ISDHHLQPYD YTNIDAAKRR
IIGKLQERKD FNKIIKDLEP EIIDDYKQSL RSAIVDYILM DSDERKRLSI EILPIEFPVL
CIRSPVPWHQ SKVTADHLMR HCLFIGNAIL KDIRDLWFSK YRQTRIIRTQ DFGTFPIPAA
EIEPKLNALC AAATDVLVKE WLADVAEIFL EKKYAWSQFF EMRPDASTAM IEKYFRSVNS
LLSKQLRIMI TETLEDFRDF FMQYKAGNAF EGDYEELKFL ETPFITVKVE PELFTTKLRC
KPSILQLHTT ISRCFDKIIK VGATIPKIET ILFPELRQTS YLFPISRFED MVLKVISDVL
DVIAKHITGP DSYLKCYENL LYITSGIAEE KLNNFFKLEP VPLLRDFEQQ IKAYDTLRKE
ISMFRCKVPL NMIEIDCSAV NDTMREILHA LRSRICNFFA DELRVNNREL CSIFDEIAEN
ISKMPETTQQ VVELYNYLCE SRDTTMFNLK RRLARSIELT LFLFDYQPLS DEDIYLNSRT
ITWPKEMEVV MELASNRLIM RKDFLETLLR SRRDTFEKKI NTMQLGIEQF KRKDPPVLTM
EEMEQAVEEI EHISTIMAEI RKEAEEINEE EGLLDMELSP YMELPIMSNT VDIFDKLWHT
ALDFHRNYDK WFYGPFIGLD AEQVREETEN TWRILYKLSR VLTEVPGARR VAEMVRGKVE
KFRQFIPVLQ TICTPGLQAR HWEAISKIVD LTIIPTDTSN LSEMIEYGLP AYIAKLEEIA
SAATKEYTLQ RNLQKMKEEW QEVYFELTLY RETGVAILTA VDDIQMLLDD HILKAQTMRG
SPFVKAFEEE MQQWEEKLIM MQDIIDQWLL CQSTWMYLEP IFSSEDIMRQ MPTESRNFRR
IDKIWRNIML YVSDNKRVID ATAMPNMLQE FKLCNSLLEE IQKGLNDYLE KKRLFFPRFF
FLSNDELLEI LSETKDPQRV QPHLRKCFEG ISKLRFTKDE EIIGMLSAEE EYVPLSGKIY
PADAKGMVER WLCQVEELMA ISLRDTAEES VIAYFEAIRE EWVLSWPGQI IICSSQIHWT
SEVYESFEDR TTASYLHKCT DQIEDIVTLV RGKLEPGARI TLNALIVIDV HARDVVKLLV
DKQVDNPLDF NWIAQLRYYW LDDCITVSMI TTNIMYAFEY LGNTSRLVIT PLTDRCYRTL
MGALKLNLGG SPEGPAGTGK TETAKDLAKA VAKQCIVFNC SEGLDYKAMG KFFKGIAQSG
AWACFDEFNR IDLEVLSVIA QQILSIQMAI SMKLDKFVFE GTELKLNPTC NVIITMNPGY
AGRQELPDNL KALFRTVAMM VPDYAMIGEI TLYSYGFMDA KNLAEKIVHT YKLCSEQLSS
QNHYDYGMRA VKTVLIAAGN LKLKYPKQDE SILVLRAIID VNLPKFLSQD VSLFNGIYTD
LFPEVHLPQP ERGELINMLK VNLEKRNLQA TDWYLEKIVQ IYEMILVRHG LMIVGMALSG
KTQAYQTLAD ALGDLSGIRK ATMREYRTIY RVINPKAITL DQLYGSFDPL SHEWKDGILA
NTFREYAQSV SLERKWIIFD GPVDAIWIES MNTVLDDNKK LCLMSGEIIQ MSVKMSMMFE
PADLEHASPA TVSRCGMIYM EPSQLGWPPI LESYKKHLKE KLLFEQYELV IELIEWLTEP
ILRFIQYNCK TFIDISEMHM FLSFTRVFSM MLAEETQVST VWLQCVLLFS MVWGMCSTLL
SGSRKLFDVY LRKLLLGNID EYPKPKVFKL TKQQIFPDRG TVYDWIYDKR NNGCWISWID
TMQQVPLSAT AKASELIIQT TETSIQHFFI KQFMRRSIPI LFVGPTGTGK SAIVLNYLMS
LPREKFLENV INFSARTNAP LTQEIVMSKL DRRRKGVYGP AMGKKCVLFV DDLSMPQVEM
YGAQPPIELL RQWIDHGYWF DPKDTSILYL ADILLIAAMV PPGGGSNIVT PRFTRHMHVI
GIDSFEEATM MKIFSSILDW HFAKGFIMEV SRLSKMMVNA TLDIFLGAIK NFLPIPSKSH
YKFNLRDFSR VINGVLLVPA ARMRDPNKLI RLWIHEIYRV FHDRLIDDTD RETLFKMVRH
TCYDQLRQPL DKVLANLLKP GEKMITSSHI RDLFFGNYIE PDADPKIYDE ITNLEDLQEK
MDYYLAEYNA VSQTPMNLVL FRYAIEHVSR ISRVLLQDNG HALLVGMGGS GRNSCARLAT
SMCEYLIQQI EITKTYEMPE WREDLKYLLL RVGCDGKPTV FIFGDHQIKD ESFIEDINMI
LNTADVPNLY AVEEKAEILE KMTTVAREMS GGKKVETTPM ALYNLFIERI KKNLHVILTM
SPIGEAFRNR LRMFPSLINC CTIDWYTLWP EDALERVARM SLRDLDIGSE LREKCVQICK
QFHTSVSITS EDYYLTYSRR YYVTPTSFLQ LIKSLYRLYG QKIEQITIQQ NRYETGLEKL
DFAAGQVAIM QDELQQLQPK LLAQSQLSDK LMIRIEQDTI NVEAKKEIVA ADEALANEAA
AAAQAIKDDC ESDLAEATPA LESALAALDT LKPADITIVK AMKSPPAGVR LVMEAVCVLK
GVKPDRVQDP ITGQMIDDYW PASIKLLGDM KFLENLKNFD KDNIPPAYMK RIRERFINDR
SFQPEAIKKV STACEGLCKW VRAMEVYDRV IKVVAPKKAM LAEAEAALAA QMEMLNEKRA
LLQEVTQKLQ SLNDEFAECM REKKKLEDQI DYCRQKLERA EKLLGGLSGE KDRWSETANK
LGASLGNVIG DVLLSSGMVA YLGAFTVEYR NKLINQWHAS CMNAAIPCST KFNLIDILGE
PIEIRSWTIQ ELPADSFSIE NGIIVKHADR WPLMIDPQNQ ANKWIKNMEK PNKLTVIKLT
DPNYVRVMET SIQLGTPVLL ENILEEIDAI LEPVLLKNIY KQRGVLYMKF GETVLEYNPN
FRFYITTRLR NPHYLPEITV KVTLLNFMIT PQGLQDQLLG IVVAKELPTL EEKKNQLIVE
GANNRKILKE IEDKILEVLT TSEGNILEDE TAIKILSTSK VLSEDIQAKQ EIAMKTSAEI
DKARNGYQPV SKHGAVLFFC ISELANIDPM YQYSLPWFLH LYVTAIAHSE HSDDLDTRMN
SLNSYFTASI YRNVCRSLFE KDKLIFSLVL CVGLLRAAHK LEEDLWVFLL TGGIALDNPY
PNPDPSWLSD KSWSEVVRSS LLPGLEKLRE SFQSNISQWK MYYDLSNPQE HPFPPPFERE
GESLRKLVIL RCVRKDKLVA AVQAFIIHHM GASFMEPPPF DLQSSYDDSN NVTPLIFVLS
PGSDPMAGLI KFAEDRGISK KNLMTISLGQ GQGPIATSMI ERGIKSGEWV ILQNCHLAIS
WMKELDRICD EIIVPENTHR DFRIWLTSYP SKGFPVSILQ NSVKMTNEPP KGLKNNLLRS
YMNDPISDPK FFRECTKVVE WRKLLFSLCF FHAVVQERRS FGPLGWNIPY EFNESDLRIS
ILQLQLFLND YNEVPFDALI YLTGECNYGG RVTDDKDRRL LNSLLKNFYN SEVITKIRYS
FSPSGIYHMP EDTDHDECLK YIRSLPINQM PEVFGLHENA DIAKDNREAI QLLAGALLTQ
PQISGIGVER DMDEVVFALA GEILSKMRPQ FDIESASNKY PVLYMNSMNT VLRQELVKFN
ELINVIKETL NNVQKAIRGQ VLMSPELEEV YVSMSIGKVP LAWDKKSYPS LKPLGSYVND
LLARLQFLQN WIDHDAPNVF WISGFFFTQS FLTAVLQNYA RKHKIPIDRL DFEFEITPFE
SSVDTAPSHG VYIIGLFLEG ARWNREKRLL DESKPKIMFD MLPIIWLKPG IKIKFDIRDV
YHCPVYKTSA RRGVLATTGH SSNFILYILI PTDIDESHWI KRGVAALCQL DD
//
