ID   E2AQI4_CAMFO            Unreviewed;       728 AA.
AC   E2AQI4;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   SubName: Full=Angiotensin-converting enzyme {ECO:0000313|EMBL:EFN64293.1};
GN   ORFNames=EAG_12076 {ECO:0000313|EMBL:EFN64293.1};
OS   Camponotus floridanus (Florida carpenter ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Formicinae; Camponotus.
OX   NCBI_TaxID=104421 {ECO:0000313|Proteomes:UP000000311};
RN   [1] {ECO:0000313|EMBL:EFN64293.1, ECO:0000313|Proteomes:UP000000311}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C129 {ECO:0000313|Proteomes:UP000000311};
RX   PubMed=20798317; DOI=10.1126/science.1192428;
RA   Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA   Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA   Wang J., Liebig J.;
RT   "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT   saltator.";
RL   Science 329:1068-1071(2010).
CC   -!- SIMILARITY: Belongs to the peptidase M2 family.
CC       {ECO:0000256|ARBA:ARBA00008139}.
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DR   EMBL; GL441773; EFN64293.1; -; Genomic_DNA.
DR   RefSeq; XP_011262230.1; XM_011263928.2.
DR   RefSeq; XP_011262232.1; XM_011263930.2.
DR   RefSeq; XP_011262233.1; XM_011263931.2.
DR   RefSeq; XP_019884228.1; XM_020028669.1.
DR   AlphaFoldDB; E2AQI4; -.
DR   EnsemblMetazoa; XM_011263928.3; XP_011262230.1; LOC105254945.
DR   EnsemblMetazoa; XM_011263930.3; XP_011262232.1; LOC105254945.
DR   EnsemblMetazoa; XM_011263931.3; XP_011262233.1; LOC105254945.
DR   EnsemblMetazoa; XM_020028669.2; XP_019884228.1; LOC105254945.
DR   GeneID; 105254945; -.
DR   KEGG; cfo:105254945; -.
DR   InParanoid; E2AQI4; -.
DR   OMA; AFQLYEY; -.
DR   OrthoDB; 3671409at2759; -.
DR   Proteomes; UP000000311; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR   GO; GO:0008241; F:peptidyl-dipeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR001548; Peptidase_M2.
DR   PANTHER; PTHR10514; ANGIOTENSIN-CONVERTING ENZYME; 1.
DR   PANTHER; PTHR10514:SF27; ANGIOTENSIN-CONVERTING ENZYME; 1.
DR   Pfam; PF01401; Peptidase_M2; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000311};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..728
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003157596"
FT   TRANSMEM        693..713
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   728 AA;  83950 MW;  F63419D6AE9D1F91 CRC64;
     MLSKWNWIIF NLIVCVTTAP LNDNLLKDEI KAFLQLIELD YEDACYSTAN VQWSFITSPS
     NKTLSIWEMQ QYNDSKSIKT WKNEAINKIE DTKERLDQSL QYKYDIIKKP GDILLRDKDW
     EKLIHFAGIM ELQPIISHTN KSHNYSREDV EYFLSHSGKF EDKQTVWNNW YRQLIPLVTN
     YSNNLQLVTK AAKENGAKTV EEYWEMLSGY SDGYDKINNE WSRINNLYKK IVKFISMNLA
     QKYEFAINDT LPAHLLGGLQ RYDWTDVSSD VLPHSELIYD IKKNLWTKKY VGKSLYKTAS
     KLGSILLKQV PQAEFWDKSE FNQSCPSRLL NFCHDGTMRV STCSKATMSN FLRAHEDMGK
     ILFNQMIIES TPILNTINRY SGLEEGISTL FGILSVSPAW LNQTHLMNGT NDNEQRMIVS
     LMLTALNVLP RLAYYYAADL WRLNAIQENI TDPANLVSSW WKYREEYEGI SSNNKDNPTF
     LDDNHIIMNK PYLPKILGIM VSFLLYEYTV DSTEVRYSEI DGKLINGNII KMIQQGGALH
     WQDILDKFIN IDDVSVDALI SYFTPLEEFI EENEKEFKYK SGAIADKELQ ELEKDVLQEI
     NAPTTVTPQP TNTVISTVTK ATSSPNKITS NAKNMQAKVE KSLETKSSMY IREDKLNNSD
     LNSSNKTSLN KSLTLDAFDD TQDNTHQINT SKAVWTVSSV LVAIVIICII AIFGRRRCHK
     TPKNRRYV
//