ID E2AUJ6_CAMFO Unreviewed; 906 AA.
AC E2AUJ6;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=Enhancer of polycomb-like protein {ECO:0000256|RuleBase:RU361124};
GN ORFNames=EAG_08984 {ECO:0000313|EMBL:EFN62890.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421 {ECO:0000313|Proteomes:UP000000311};
RN [1] {ECO:0000313|EMBL:EFN62890.1, ECO:0000313|Proteomes:UP000000311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C129 {ECO:0000313|Proteomes:UP000000311};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC is involved in transcriptional activation of selected genes principally
CC by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. Involved in gene silencing by neighboring
CC heterochromatin, blockage of the silencing spreading along the
CC chromosome, and required for cell cycle progression through G2/M.
CC {ECO:0000256|ARBA:ARBA00025513}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU361124}.
CC -!- SIMILARITY: Belongs to the enhancer of polycomb family.
CC {ECO:0000256|ARBA:ARBA00008035, ECO:0000256|RuleBase:RU361124}.
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DR EMBL; GL442829; EFN62890.1; -; Genomic_DNA.
DR RefSeq; XP_011264238.1; XM_011265936.2.
DR RefSeq; XP_019884616.1; XM_020029057.1.
DR AlphaFoldDB; E2AUJ6; -.
DR STRING; 104421.E2AUJ6; -.
DR EnsemblMetazoa; XM_020029057.2; XP_019884616.1; LOC105256205.
DR GeneID; 105256205; -.
DR KEGG; cfo:105256205; -.
DR InParanoid; E2AUJ6; -.
DR OMA; FGNWPWC; -.
DR OrthoDB; 5398022at2759; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR024943; Enhancer_polycomb.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR PANTHER; PTHR14898; ENHANCER OF POLYCOMB; 1.
DR PANTHER; PTHR14898:SF0; ENHANCER OF POLYCOMB-LIKE PROTEIN; 1.
DR Pfam; PF10513; EPL1; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361124};
KW Reference proteome {ECO:0000313|Proteomes:UP000000311};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU361124};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU361124}.
FT DOMAIN 7..141
FT /note="Enhancer of polycomb-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10513"
FT REGION 303..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..661
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 766..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..906
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 906 AA; 99796 MW; F80267BE65FCFAFF CRC64;
MSKLSFRARA LDASKPMPVY MAEELPDLPD YSAINRAVPQ MPSGMEKEEE CEHHLQRAIC
TGLIIPTPEV TDLADAEAYD RIYPADYKMP RQLIHMQPFA MEQDIPDYDM DSEDEKWVAV
QSRKMDLTPL QFEEMMDRLE KSSGQTVVTL SEAKALLKED DDLIIAVFDY WLNKRLKTQH
PLLLTVKTEN RFGSTTNNPY LAFRRRTEKM QTRKNRKNDE TSYEKMLKLR RDLSRAVTLL
EMVKRREKTK REHLHLTIEI YEKRYQAQDF NGQILAEVSA LKTPRPAFAP LFTNQFVHQN
WTNKDEVMPR KEKRQYKKRK HKTDSRTGNL EDTSVRSGTG SGSGRGNRPV LGGGLDPLIS
SDEDSPLPSH SHSQPSLSSD RDDEDTVDEG QFAFRRNRNN SYLPPVSGGF GNWPWCDKDE
GGLAEKKYRF ALTSISKPVP RCIGLARRRI GRGGRVILDR CTADIDDMWS SLDFTIHDSK
REQQMDSNAT ATATTTVKKE WLHFRPKTPP VSVHSPSEES SDDMDLDVEP MTSRSKLPYP
FPPEATSICI EVEPERAGDE SPFTSEFNIA DYFPTDTVSD FEFAVANLNS TGNTSGLSDN
SGVKESRTDD ELGSSHFVVT PLMSNLFAPP TTTQQARPPQ CSGGSFSGGS SVHTSTSSSS
IPPLSSVIVT CTTNQVAVAS STVSTQCTNV GMGVTVDTQS NHHQLNKQQH RQLPNNSNAA
SILSKSLTSP TNNRNGSNCG VGSGGGNGGG SGSSANIRVF SASTACSGGS GSSGGSGNGS
SVTNFGNSHQ NGPLPHINNS NNLTNSTHVV NNQQSTLVLP QKHPPSNLLP GLIAQSKLAS
LARQQQQQTQ NQAQQVPTSG EITLNSNSEN LDMEVDGVDN SPCDSKPQQQ QLVRANKTNS
LAMEVT
//
