ID E2B210_CAMFO Unreviewed; 1047 AA.
AC E2B210;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Bumetanide-sensitive sodium-(Potassium)-chloride cotransporter {ECO:0000313|EMBL:EFN60266.1};
GN ORFNames=EAG_04345 {ECO:0000313|EMBL:EFN60266.1};
OS Camponotus floridanus (Florida carpenter ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Formicinae; Camponotus.
OX NCBI_TaxID=104421 {ECO:0000313|Proteomes:UP000000311};
RN [1] {ECO:0000313|EMBL:EFN60266.1, ECO:0000313|Proteomes:UP000000311}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C129 {ECO:0000313|Proteomes:UP000000311};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GL445031; EFN60266.1; -; Genomic_DNA.
DR RefSeq; XP_011267934.1; XM_011269632.2.
DR AlphaFoldDB; E2B210; -.
DR STRING; 104421.E2B210; -.
DR GeneID; 105258406; -.
DR KEGG; cfo:105258406; -.
DR InParanoid; E2B210; -.
DR OMA; DTISFEM; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000000311; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF103; SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000311};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 113..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 567..600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 116..645
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 654..1047
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 805..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..842
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1047 AA; 115725 MW; F96013B611B7023B CRC64;
MAHENGINGG DTDSETVELN LVRRTRFHVN RVDSLEGRTS LLGEQETKKS LRHMTREALP
RLDNYRNIMS IQAAHRPSLD ELHNPTLLNK GPGSHTLTVP QLKSTASGVK FGWIQGVLMR
CLLNIWGVML FLRLSWVVAQ TGIGQAILLI LTTTVVTTIT ALSMSAISTN GLIKGGGTYY
MISRSLGPEF GGSIGLIFSL ANAVACSMYV VGFCESLIDC LNSFNLCIVD CGITDIRIVG
CLTIVVLLII VVIGLEWEAK AQIFLLIILL LAIGDFTIGS FIGPKSNEEK AKGFIGYNAE
LFKENLYPNY RYSEGVEHNF FSVLAIFFPA ATGILAGANI SGDLKDPQTA IPKGTLLAIL
LTSLSYLIIA IIVGSTVMRD ASGNVNDLWA IYNSFSTLSI LGADNSTAIE NNTNIIESAN
RTWSVYQTAF NCTGGSCNYG THNSFEVIQL VSAFGPFIYA GCFAATISSA LASLVSAPKI
FQALCLDKLY PGIAWFSGDK DKEPIRGYLL TFIIAVGFIL IGELNAIAPL ISNFFLAAYT
LINFSTFHAS LAKPIGWRPT FKYYNMWLSL AGAILCVSVM FLISWWTALI TLSVVLALYL
IVSYRKPDVN WGSTTQAQTY NNALTAVQQL DRVEDHVKNY RPQLLVLTGA PNTRSSLVDF
AHHITKHQSL FICGHIIETS ISYKTRNSML QNCSSWLRAN KIKAFYSLVD GASFQDGATS
LLQAAGLGKM RPNILLMGYK QDWATCPQNN LNMYFNTMHK ALDMHIAVAL LRLQEGLDCS
VIGEDQKRLM PTSIPGNQSF SQLSQASSVS DISIPGSPAP RRSRTINEYP NPSSEEQREN
RSNIMPITNI LNVVTKFQRK HKKGTIDVWW LYDDGGLTLL LPYIISMRRN WSNSKLRVFA
LANKNSELEY EQRNMASLLS KFRIDYSALK VIPDISKPAQ TSTKAFFDSL IAGFQESSAD
SKNSDDDIIK DSELMAMNEK TNRHLRLREL LLENSMEANL VVMTLPMPRK GAVSAPLYMA
WLETLTRDMP PFLLVRGNQT SVLTFYS
//
