ID E2B806_HARSA Unreviewed; 1508 AA.
AC E2B806;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Rho-guanine nucleotide exchange factor {ECO:0000313|EMBL:EFN88191.1};
GN ORFNames=EAI_17255 {ECO:0000313|EMBL:EFN88191.1};
OS Harpegnathos saltator (Jerdon's jumping ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN [1] {ECO:0000313|EMBL:EFN88191.1, ECO:0000313|Proteomes:UP000008237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN88191.1,
RC ECO:0000313|Proteomes:UP000008237};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; GL446268; EFN88191.1; -; Genomic_DNA.
DR STRING; 610380.E2B806; -.
DR InParanoid; E2B806; -.
DR OMA; TPHSHEF; -.
DR Proteomes; UP000008237; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd20815; C1_p190RhoGEF-like; 1.
DR CDD; cd15789; PH_ARHGEF2_18_like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR PANTHER; PTHR13944; AGAP007712-PA; 1.
DR PANTHER; PTHR13944:SF21; CYSTS, ISOFORM C; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008237}.
FT DOMAIN 668..856
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 80..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 403..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 465..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1195..1216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1407..1500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1276..1342
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 80..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..448
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..490
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1201..1216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1407..1479
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1480..1497
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1508 AA; 168434 MW; FD2C197E3E2B9483 CRC64;
MEKRQEVLAP FSSDECPNSG EDSEEDVITD YLGSSHSDCD RMPIINGDLR DLSLHGGIVT
ETGYTKDNTA KTPISMSAVG MTSDEQHQQQ QQQQHQQQQQ QQHHQHHHHH HHPLLTLGTN
IQAQPNPLVP IISVTPHSPG LAKNYPVLEE NLQQLHEIHD CIQRMRDLTL STLGYHNRAS
NNDAAQRLTS SCPTLCPLTS AELAPRPGNP HDTGSDPDLL ANCSTNSSPT HFPGSVGHSR
SQRAQAGIDR RRSWTGDLED LEESRRGGRH RYSGQNHLQA QNMVNIDRYL LGPEVGAGSI
SRQRSISLSS LDSENELELD GKSCTGPVAV SNRACRSQTS THSLNEADLV QSEYQKIVTK
RGSQRLAESS SLMPGLTGSR LPLQKSISTP SIVTPQVHAH LGEAGTRTTP SLAARHERNE
KGSGSETETE DLHTPHSHEF HEDREGTPSA QISLDELLTD GTVYDDHHSE KTRRKRGSIF
FRKKKDKSGK KTSQQQHLWV TMTVGTQGSL LCDVCMKHST NKPLLHCDNC GASVHQSQGC
KDQLVLECIK SKHHSGKSAA KSSSNASTMS NSNNVKRGST TSLPLPTSSG SGSQTINEEK
DGDGGQHRDL SSGWEEFDFG EDHQFTVGDL EEIDPELGLG KEEPDSWSAA IGRNVALRLV
DHCEREVKRQ EHIYEFVLTE KHHCLVLLAM ERIFAEGLQR HFRLGQPDLE RMFPRLRDLI
EIHLRFLQKL RKRQNANSVV STIADILVEQ FSGENAQRMK SAYGEFCSRH RDAVEAYKYY
QRHDSRFARF VRHCQTNPLL KKKGIPECIL FVTQRLTKYP LLVEPLIKTG VVQEESENLR
KALLLVKEIL ADVDACVADK EREDRKLEIY NKIDAKSFAT YRGAKFKKSD IMAFNRILKF
EGTAYLMQGR GKMTAIVVVV LSDILFFLAE RDQKYAFFVP DNKAGIVSLQ KLLVREKAGQ
ESSIYIISSN PAEPEMFELK IQKPKDKQLW IQSIRSAVEA CPQEPENEAD TLTESSSELR
DTRSSSISLI SVEEKQRIAK AKESHILRIV GELRKKDAEQ ALLFEEKINL QMRLLHAANI
WGANESDNER IEKLEKLEKE VPDYTRLAHN EGSDTTQLWQ EVVMAVQEAT RLASSLSFSA
GGATLSRSLS SAGERHSEAY VPPALCVPRR AETFAGFDHS KERHPLRDSN AVIPVPKLGE
LPKESPDEKE GQELETNKDQ QLAAIRLSHH VYTLLCIISN QMTTIDGLQA QLSACKEGSM
PMGKSSNSRP NSNRQLEELR NLQDQLCREK AAFRAASQQE KSQLEEERTD LVRQREQLAA
EQRDVTQQRD QLYRRLEALE RQGVTLVGSS ASSTTIHLSH LTQNAEAVQT RKSQPEAKRI
PLNLISATNQ QKVQSNLPVK QQLPLKLASG SNNNTSNNSP DRHSRTGSSP AIVTGSAYSS
PELGNNSHAG SSHTHSSNRS LRITRSPPDS YAHQTQHQQR GDPPPPPQQP PPPTSAQQQP
LEEEVIFF
//
