UniProt: E2BAV2

Database: UniProt
Entry: E2BAV2_HARSA

LinkDB:  E2BAV2_HARSA 
Original site:  E2BAV2_HARSA

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Ontology (3)   
   GO (3)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (2)   
   RefSeq(pep) (2)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (3)   
   InterPro (1)   
   Pfam (1)   
   PROSITE (1)   
Literature (1)   
   PubMed (1)   
All databases (12)   

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ID   E2BAV2_HARSA            Unreviewed;       396 AA.
AC   E2BAV2;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Innexin {ECO:0000256|RuleBase:RU010713};
GN   Name=inx {ECO:0000256|RuleBase:RU010713};
GN   ORFNames=EAI_06617 {ECO:0000313|EMBL:EFN87180.1};
OS   Harpegnathos saltator (Jerdon's jumping ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX   NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN   [1] {ECO:0000313|EMBL:EFN87180.1, ECO:0000313|Proteomes:UP000008237}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN87180.1,
RC   ECO:0000313|Proteomes:UP000008237};
RX   PubMed=20798317; DOI=10.1126/science.1192428;
RA   Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA   Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA   Wang J., Liebig J.;
RT   "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT   saltator.";
RL   Science 329:1068-1071(2010).
CC   -!- FUNCTION: Structural component of the gap junctions.
CC       {ECO:0000256|RuleBase:RU010713}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU010713};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU010713}. Cell
CC       junction, gap junction {ECO:0000256|RuleBase:RU010713}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00351, ECO:0000256|RuleBase:RU010713}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00351,
CC       ECO:0000256|RuleBase:RU010713}.
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DR   EMBL; GL446860; EFN87180.1; -; Genomic_DNA.
DR   RefSeq; XP_011135329.1; XM_011137027.1.
DR   RefSeq; XP_011135330.1; XM_011137028.2.
DR   AlphaFoldDB; E2BAV2; -.
DR   EnsemblMetazoa; XM_011137027.2; XP_011135329.1; LOC105180755.
DR   EnsemblMetazoa; XM_011137028.3; XP_011135330.1; LOC105180755.
DR   GeneID; 105180755; -.
DR   KEGG; hst:105180755; -.
DR   InParanoid; E2BAV2; -.
DR   OMA; VVKFSNM; -.
DR   OrthoDB; 2873211at2759; -.
DR   PhylomeDB; E2BAV2; -.
DR   Proteomes; UP000008237; Unassembled WGS sequence.
DR   GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR000990; Innexin.
DR   PANTHER; PTHR11893; INNEXIN; 1.
DR   PANTHER; PTHR11893:SF37; INNEXIN INX3; 1.
DR   Pfam; PF00876; Innexin; 1.
DR   PRINTS; PR01262; INNEXIN.
DR   PROSITE; PS51013; PANNEXIN; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|RuleBase:RU010713};
KW   Gap junction {ECO:0000256|ARBA:ARBA00022868, ECO:0000256|PROSITE-
KW   ProRule:PRU00351}; Ion channel {ECO:0000256|RuleBase:RU010713};
KW   Ion transport {ECO:0000256|RuleBase:RU010713};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW   ProRule:PRU00351}; Reference proteome {ECO:0000313|Proteomes:UP000008237};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW   ProRule:PRU00351};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|PROSITE-
KW   ProRule:PRU00351}; Transport {ECO:0000256|RuleBase:RU010713}.
FT   TRANSMEM        115..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT                   ECO:0000256|RuleBase:RU010713"
FT   TRANSMEM        272..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00351,
FT                   ECO:0000256|RuleBase:RU010713"
SQ   SEQUENCE   396 AA;  44665 MW;  15C49797A0F2298C CRC64;
     MAVFGLVSSV AGFVKVRYLI DKAIIDNMVF RAHYRVTSAI LFACCIIVTA NNLIGDPINC
     VADGAVSPHV LNTYCWITYT FTLPQNNLKP VGTHVAHPGL GGDYGEKRFH SYYQWVPFML
     FFQGVLFYVP HWMWKQWEEG KVRIISEGMR GANVETKQER QAKIDRLVQY VIETLHLHNS
     YAAGYFFCEA LNFVNVVGNI FFVDTFLGGA FLTYGTDVVK FSNLNQEQRS DPMVEVFPRV
     TKCTFHKFGA SGTIQKFDAL CVLALNILNE KIYIFLWFWF IILAVMSGAA LLYSMAVVLL
     PSTREAILKK RFKFGTPAIV SALIRKTQVG DFLLLHLLGQ NMNIMAFNEV LEELCRRLQF
     GSSSGASPTS VPSAPSTLEM SPIYPEIEKY AKDTEI
//

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