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Database: UniProt
Entry: E2BEA8_HARSA
LinkDB: E2BEA8_HARSA
Original site: E2BEA8_HARSA 
ID   E2BEA8_HARSA            Unreviewed;      1358 AA.
AC   E2BEA8;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   08-NOV-2023, entry version 46.
DE   RecName: Full=alpha-1,2-Mannosidase {ECO:0000256|RuleBase:RU361193};
DE            EC=3.2.1.- {ECO:0000256|RuleBase:RU361193};
GN   ORFNames=EAI_07877 {ECO:0000313|EMBL:EFN85953.1};
OS   Harpegnathos saltator (Jerdon's jumping ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX   NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN   [1] {ECO:0000313|EMBL:EFN85953.1, ECO:0000313|Proteomes:UP000008237}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN85953.1,
RC   ECO:0000313|Proteomes:UP000008237};
RX   PubMed=20798317; DOI=10.1126/science.1192428;
RA   Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA   Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA   Wang J., Liebig J.;
RT   "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT   saltator.";
RL   Science 329:1068-1071(2010).
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PIRSR:PIRSR601382-2};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 47 family.
CC       {ECO:0000256|ARBA:ARBA00007658, ECO:0000256|RuleBase:RU361193}.
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DR   EMBL; GL447768; EFN85953.1; -; Genomic_DNA.
DR   RefSeq; XP_011137212.1; XM_011138910.2.
DR   STRING; 610380.E2BEA8; -.
DR   EnsemblMetazoa; XM_011138910.3; XP_011137212.1; LOC105181861.
DR   GeneID; 105181861; -.
DR   InParanoid; E2BEA8; -.
DR   OMA; DFHYFHA; -.
DR   OrthoDB; 942598at2759; -.
DR   Proteomes; UP000008237; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004571; F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 1.50.10.10; -; 1.
DR   Gene3D; 3.50.30.30; -; 1.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR044674; EDEM1/2/3.
DR   InterPro; IPR001382; Glyco_hydro_47.
DR   InterPro; IPR046450; PA_dom_sf.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR036026; Seven-hairpin_glycosidases.
DR   PANTHER; PTHR45679; ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2; 1.
DR   PANTHER; PTHR45679:SF2; ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 3; 1.
DR   Pfam; PF01532; Glyco_hydro_47; 1.
DR   Pfam; PF02225; PA; 1.
DR   PRINTS; PR00747; GLYHDRLASE47.
DR   SUPFAM; SSF52025; PA domain; 1.
DR   SUPFAM; SSF48225; Seven-hairpin glycosidases; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|PIRSR:PIRSR601382-2};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Glycosidase {ECO:0000256|RuleBase:RU361193};
KW   Hydrolase {ECO:0000256|RuleBase:RU361193};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR601382-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008237};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..1358
FT                   /note="alpha-1,2-Mannosidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003157259"
FT   DOMAIN          650..744
FT                   /note="PA"
FT                   /evidence="ECO:0000259|Pfam:PF02225"
FT   REGION          1163..1195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        134
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT   ACT_SITE        279
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT   ACT_SITE        373
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT   ACT_SITE        391
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601382-1"
FT   BINDING         477
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601382-2"
SQ   SEQUENCE   1358 AA;  153926 MW;  DF761FD711B6D2B1 CRC64;
     MACDTLIWGL LFLGCSIQAL WAMSEDDPLE YMNKEEREAL KEEARDMFYH AYNAYMDNAY
     PADELMPLSC KGRYRGSEPN RGDIDSTLGN FSLTLVDTLD TLVVLGDLEE FENAVKLVAR
     DVSFDTDVIV SLFETNIRML GGLLSGHILA EYLQQRADIM PWYRGELLDL AKDLGYRFLP
     AFNTTTGIPY GRINLKHGMR GVPMEVSRET CTACAGSMIL EMAALSRLTG ESIFEEKAQK
     AMDVLWRMRH RGTDLMGSVL NVNSGDWVRR DSGVGAGIDS YYEYCLKAYI LLGDEKYLGR
     FNKHYQAVMK YVSQGPMLLD VHMHRPNTNS KNFMDALLAF WPGLQVLKGD IKPAVETHEM
     LYQVMQRHNF IPEAFTTDFQ VHWGHHPLRP EFLESTYFLY RATGDHYYLG VGRKVLKSLQ
     TYARVPCGYA AVSDVRTNKH DDTMDSFVLS ETFKYLFLLF TEPGELFLDL DEFIFTTEGH
     LLPLTLASIR TNISSDFERD IVHVDEFDRT CPNSLHLFPA SVRQPLRNMV EDVCPRRSLK
     RRLSASQFQA NNLEHLKMLS DMGITTLTLA DGRVQLLHTF SNAKTPQDSE EGLLFMQEMV
     ELSKMQTQQP ETKPQTVTFV KPKTDPPEKV TLLAGPAQFG PELQSFDKIT GKVIFTYPPA
     ACTELLNADK LAGKIVIMDR GNCMFIEKAR RIQQAGALAG IVLDNVAGSS AATSPMFAMS
     GDGKDVDDVT IPVVFLFFTE AAELMKAINT ANGDLTVTLG IYSSKEEVQL KAPTDLSLFE
     RVKGSLRSFL SRHLTPQATT TGSNMDITIP VVESQEYQED TIDFHYFHAE IIKDSLGGEV
     RITAPSEDAI IILRPVSTPV EILWHQLKEV FVNQIFLNSK QNKGIRIRSF ILESYYNWVN
     KARGVLTKTS LSYKVRWFLS ELLVVAPNSS IRKMGQLLEL TKQKLLKQYL LTNMDTMVLN
     LKTVATKLKN MKSVKPDMEQ LLKLSESGIA QVENYSFLRH LLADLFDEED EIVSQHIAFL
     DHIHAEVHIT YQEILIDGVQ KHLEKTGEED SSYYDILIAD LQKNLKNVDK GENLLGKTRE
     DDLAVAEFIS DCSSGKSELK GRNIKVLDQN MRILKKGREL DIEKLEDFEY FILTEIGKAI
     KHSAQNILHK YEGTSDVTKN AVTEGKKDKN SGKSEITLHS PLNQSKGEDR KSRARNSLKE
     EIDFLRTTKS ANVKIEETVV KDGQKEKFAD STVNMKASNI GITSTDEENV LLQEIRKDIS
     DTQHKQKTDS KAKLSKQKNV VESEIVPTDL LKEFKRPIWA VNEEKDFTEF RKDSQVSEPQ
     HSAVESSELK YEKKYINIDK DKEAKPKTHT AKHIDDEL
//
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