ID E2BFZ1_HARSA Unreviewed; 1482 AA.
AC E2BFZ1;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=DNA polymerase alpha catalytic subunit {ECO:0000256|ARBA:ARBA00017212};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=EAI_14608 {ECO:0000313|EMBL:EFN85393.1};
OS Harpegnathos saltator (Jerdon's jumping ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN [1] {ECO:0000313|EMBL:EFN85393.1, ECO:0000313|Proteomes:UP000008237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN85393.1,
RC ECO:0000313|Proteomes:UP000008237};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755}.
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DR EMBL; GL448096; EFN85393.1; -; Genomic_DNA.
DR STRING; 610380.E2BFZ1; -.
DR InParanoid; E2BFZ1; -.
DR OMA; MTKMNVG; -.
DR Proteomes; UP000008237; Unassembled WGS sequence.
DR GO; GO:0042575; C:DNA polymerase complex; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:1902975; P:mitotic DNA replication initiation; IEA:InterPro.
DR CDD; cd05776; DNA_polB_alpha_exo; 1.
DR CDD; cd05532; POLBc_alpha; 1.
DR Gene3D; 2.40.50.730; -; 1.
DR Gene3D; 3.30.70.2820; -; 1.
DR Gene3D; 6.10.10.100; -; 1.
DR Gene3D; 1.10.3200.20; DNA Polymerase alpha, zinc finger; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR024647; DNA_pol_a_cat_su_N.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR038256; Pol_alpha_znc_sf.
DR InterPro; IPR045846; POLBc_alpha.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR015088; Znf_DNA-dir_DNA_pol_B_alpha.
DR NCBIfam; TIGR00592; pol2; 2.
DR PANTHER; PTHR45861; DNA POLYMERASE ALPHA CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR45861:SF1; DNA POLYMERASE ALPHA CATALYTIC SUBUNIT; 1.
DR Pfam; PF12254; DNA_pol_alpha_N; 1.
DR Pfam; PF00136; DNA_pol_B; 2.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR Pfam; PF08996; zf-DNA_Pol; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF90234; Zinc finger domain of DNA polymerase-alpha; 1.
PE 3: Inferred from homology;
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000008237};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 39..99
FT /note="DNA polymerase alpha catalytic subunit N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12254"
FT DOMAIN 469..762
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 832..1026
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT DOMAIN 1029..1232
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT DOMAIN 1269..1447
FT /note="Zinc finger DNA-directed DNA polymerase family B
FT alpha"
FT /evidence="ECO:0000259|Pfam:PF08996"
FT REGION 20..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1458..1482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1482 AA; 169103 MW; DCE9499FD4AD57AC CRC64;
MNDLSKYCSF ALLNETALAS TSGRSKRQRT DKTGRLSALE KLKEARSGKR KYEVGELENV
YDEVDEKEYS NTVLKRQRDD WIVDDGGSGY VEDGREIFDD DLDEESIQEA KRQKYNMAGP
RKKRKEEERR KGDIQNMFRN MPSKKSNTNC KDDDILGELL SEISTSKKTV DNSKRIQEPR
EIKNKFCHTV HSDLAYKNQS SPVNQEANDK KIIQKPEENA SQIIEDDDDT AAIFDAPQKK
NTNKPMASND VRCYRNMSQR IEDTKLEEMQ ENGISKQTES KDTKHCQSAS QLIDNESMEV
ELCSMSELAS VCLTAEKKSN MDLNECVGDL STIDFDDGSM DADFSSSVNS VKPQQNRTDI
TQNVTCKTTV IGIKVGNVVD FTEVVPQLVK TKDEVEVFRF YYLDAYENPY KNPGTVYLFG
KTYVASRDMY CSCCVMVHCI PRRIYLLPRK YLKTPKSGEP QLTTIEDVYK EFDEYASKMR
IMEFNCKETK KHYSFEKEGT PKTSDYLEVR YNARYPAIEA NYSGPAIERV FGSTVNALEL
LLIERKIKGP GWLDVKNVSP TAGRFAWCQQ IVVTSDIDNV SLCSQDNAKP PMMIATLNVR
MSLNSKLQNE VVMVAVLIHH KYNVDKEPPK PPYDRQFCFV TRPRDISWPR QVRDVLPRVP
NTEIIKCETE SELLEELLTL MQKADPDLIV GYDCAFQFDV LMQRMFALKV SNWNRMGRLK
STTPPLLRGK IVLNQAFVGR PICDIQISAK ELNLKVRSYD LLSLCSAVLK TKEHECKEIT
PAETPLYYNT ADKITSLIHA TLKEAKYIIT MVMDLNVIPL ALQITCLAGN ILSRTLLGGR
AERNEYLLLH AFHLKEYVTP DKKTEKKRDN DGPRKKAAAY IGGLVLDPKK GFYDKLVLLM
DFNSLYPSII QEYNLCFTTV PGAAYAEVEH LSIPDSTLET GVIPTEIHKL VKSRQQIKQL
MKTPNLTPEQ RMDYHIRQMA LKLTANSMYG CLGATHCRFY AKGLAALITA KGREILEDTK
HLVEKLQYEI MREVNNRYKK VELDIDGVFR YLLLLQKKKY AAVTMTKLPS GQLHLAQEHK
GLDIVRRDWC PLACETGKKI LDILLCDQSS ETRLEQVVQI LQNVAKSVKE GTAPMSSFVI
TKQLSKNPDA YPDKKQLSHV MVALRLNKAG GRMWKAGDTL PYIICEDGTE ASATERAYHI
DEVKNSEKLK VDVNYYLLSQ IFPVVLRICE PIEGIDDVFL ANNLGLQFIY KPKAIACEAT
LNLPLSINDE RFDNCVPLTF KCRNERCNTE IIIKDTITEF HSGRQFSLSM CPNQDCKLPP
WRYANAIQNM VQLAMRKAIG KYYNGWLECE NPLCSNRTRR LPLDFARKFP DCPVCKDISM
ARVYSGTELY NQLYYYHRMF DIGQPIYKHL LSQCPRDMIA AYNTLKEAID RQLKRNKFSC
VNITGIFSSV STNNRTGTFG GAGSQEDFDD LGDLSDDTDK EI
//
