ID   E2BK35_HARSA            Unreviewed;       750 AA.
AC   E2BK35;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   SubName: Full=Homeobox protein SIX1 {ECO:0000313|EMBL:EFN83943.1};
GN   ORFNames=EAI_09612 {ECO:0000313|EMBL:EFN83943.1};
OS   Harpegnathos saltator (Jerdon's jumping ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX   NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN   [1] {ECO:0000313|EMBL:EFN83943.1, ECO:0000313|Proteomes:UP000008237}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN83943.1,
RC   ECO:0000313|Proteomes:UP000008237};
RX   PubMed=20798317; DOI=10.1126/science.1192428;
RA   Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA   Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA   Wang J., Liebig J.;
RT   "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT   saltator.";
RL   Science 329:1068-1071(2010).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC       ECO:0000256|RuleBase:RU000682}.
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DR   EMBL; GL448740; EFN83943.1; -; Genomic_DNA.
DR   AlphaFoldDB; E2BK35; -.
DR   InParanoid; E2BK35; -.
DR   Proteomes; UP000008237; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR031701; SIX1_SD.
DR   PANTHER; PTHR10390; HOMEOBOX PROTEIN SIX; 1.
DR   PANTHER; PTHR10390:SF61; HOMEOBOX PROTEIN SIX2; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF16878; SIX1_SD; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000008237}.
FT   DOMAIN          687..747
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DNA_BIND        689..748
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          123..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          190..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          269..295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          337..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          505..566
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        141..169
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        194..232
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..295
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        337..368
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        380..395
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        409..426
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        438..470
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        518..566
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   750 AA;  82742 MW;  DEBD6A7E505F0600 CRC64;
     MFLLVINQHE AHVPSSMLRR RLWDLLDFSR KDRNAPRIAK VNPSRATARR TRTSLPEVAA
     MFLGPRISAT QFSRFGANTR VTRVEALKPS AKHNDLPSIL STAARDVESS CLTKLALKSP
     LISDQQGSRM PAFATVSKPP PAASSEASQT NSQARGSTTD TSSRRSSSVM FTEMAIRKSD
     ILTSLQHELF PETSRNSHPA ERDVDNVATE RSSVEQRWSD RCEGHGTGET PAVDDRAEEA
     RAVLTHFQIG PPVAGFVTLR SLRAFSCDAS KEPSTDSEDS NNRHVAESRR SRCGKDARGR
     NVPFCEDTMY EKGRKDELKT CSSRRAGNLQ RAKRKCNAGK GRCDKGGKDD SNPLCDTVSK
     EKCTKGPAKC LPRKSTSDKQ QPRSSTREEK KPCELSQKPS STCTHERYCA NRKGSDAPKD
     QSREQRGGEE EEEEEEDPAE QRGRRRIEVP RATSRSIRSH SRREDDRVTT TVESGGGVRG
     VVVDAPGDDA MMAYGGTAGN GGAMGPSSGG ADVLGSAGDY SPQSTPTPLT GHSSGSVENA
     YTPGTTGAAS YSPQDSPASS AGGSGKGQLP SFGFTQEQVA CVCEVLQQAG SVERLSRFLW
     SLPACTRLHR HESVLKAKAI VAFHRGQFKE LYRILESHTF SPNNHPKLQA LWLKAHYIEA
     ERLRGRPLGA VGKYRVRRKF PLPRTIWDGE ETSYCFKEKS RSVLRDWYAT NPYPSPREKR
     ELAESTGLTT TQVSNWFKNR RQRDRAAEHR
//