ID E2BQ90_HARSA Unreviewed; 484 AA.
AC E2BQ90;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Digestive cysteine proteinase 1 {ECO:0000313|EMBL:EFN82144.1};
GN ORFNames=EAI_09540 {ECO:0000313|EMBL:EFN82144.1};
OS Harpegnathos saltator (Jerdon's jumping ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN [1] {ECO:0000313|EMBL:EFN82144.1, ECO:0000313|Proteomes:UP000008237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN82144.1,
RC ECO:0000313|Proteomes:UP000008237};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; GL449698; EFN82144.1; -; Genomic_DNA.
DR AlphaFoldDB; E2BQ90; -.
DR STRING; 610380.E2BQ90; -.
DR MEROPS; C01.067; -.
DR EnsemblMetazoa; XM_011144804.3; XP_011143106.1; LOC105185372.
DR InParanoid; E2BQ90; -.
DR OMA; KAFHHFK; -.
DR Proteomes; UP000008237; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF975; 26-29KD-PROTEINASE; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000008237};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 181..237
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 266..483
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 484 AA; 55228 MW; 15223131A2D3A08A CRC64;
MVKTYQLSHK GQYGASIKIA PVTTETASNK DTCLQVNGTS DLKIQPQTIL PDTSEMECIG
EEMINGLMCE KWRLVQEIEE KTNKYTLWIR YKKSPYVPQL KEAIPVRYEM RGFNSLLGSH
YDHYYLEYDW YSSETPSSDI FKITENATCV SFPGPGENHI YTFNPMREFI HNYEDHLDEA
FHNFKKTHKK YYNSDLDHKY RKEVFRQNIR FIHSLNRANL GYQLNVNHLA DRTDLELRAL
RGNRHTKGYN GGAPFQHDIE NEISDVPDSI DWRLYGAVTP VKDQSVCGSC WSFGTTGTIE
GAYYMKYNKL VRLSQQALID CSWGYGNNGC DGGEDFRAYQ WIMKHDGLPT EEDYGGYLGQ
DGYCHINNVT KTAKITGYVN VTPLSVAALK IAIAKHGPIS VAIDASHKTF SFYSHGVYYD
PACGNTEDKL DHAVLAVGYG NMNGKDYWLV KNSWSNYWGN DGYILMAQKD DNCGVLLAPT
YVTM
//
