ID E2BW30_HARSA Unreviewed; 725 AA.
AC E2BW30;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=ATP-dependent RNA helicase {ECO:0000256|RuleBase:RU365068};
DE EC=3.6.4.13 {ECO:0000256|RuleBase:RU365068};
GN ORFNames=EAI_06481 {ECO:0000313|EMBL:EFN80062.1};
OS Harpegnathos saltator (Jerdon's jumping ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN [1] {ECO:0000313|EMBL:EFN80062.1, ECO:0000313|Proteomes:UP000008237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN80062.1,
RC ECO:0000313|Proteomes:UP000008237};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- FUNCTION: RNA helicase. {ECO:0000256|RuleBase:RU365068}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|RuleBase:RU365068};
CC -!- DOMAIN: The helicase domain is involved in the stimulation of RELA
CC transcriptional activity. {ECO:0000256|RuleBase:RU365068}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX1 subfamily.
CC {ECO:0000256|ARBA:ARBA00008765}.
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DR EMBL; GL451091; EFN80062.1; -; Genomic_DNA.
DR AlphaFoldDB; E2BW30; -.
DR STRING; 610380.E2BW30; -.
DR EnsemblMetazoa; XM_011147808.3; XP_011146110.1; LOC105187165.
DR InParanoid; E2BW30; -.
DR OMA; EYCIRAI; -.
DR Proteomes; UP000008237; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17938; DEADc_DDX1; 1.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR CDD; cd12873; SPRY_DDX1; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR24031:SF307; ATP-DEPENDENT RNA HELICASE DDX1; 1.
DR PANTHER; PTHR24031; RNA HELICASE; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU365068};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|RuleBase:RU365068, ECO:0000313|EMBL:EFN80062.1};
KW Hydrolase {ECO:0000256|RuleBase:RU365068};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365068};
KW Reference proteome {ECO:0000313|Proteomes:UP000008237};
KW RNA-binding {ECO:0000256|RuleBase:RU365068}.
FT DOMAIN 55..241
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 272..424
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 479..672
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 261..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 725 AA; 80346 MW; B37F6D7B012820E0 CRC64;
MGVLPEIAKA VDDIDWTLPT DVQAEAVPLI LGGGDVLMAA ETGSGKTGAF CLPILQIVWE
TLKDFESGGG SGASFALVQQ SAHWALSLFD RGRALAVTPD GLRCQSREQK EWHGCRANKG
VSRSGKYFFE CIVTDEGLCR VGWSTSQASL DLGTDKFGYG FGGTGKKSNA KQFDNYGEAF
GMHDVIGCFL DLVKGEIKFT KNGVDLGVAF TLNAQQKSQT YYPAVVLKNA EMSFNFGAQP
FKHSPSNDYV AVSSVPKESI KYNPVNSNQT QTSQSGKPTS NAPQAIIIEP SRELAEQTYS
QIQKFKTHLK DPMVRELLVI GGVNVKDQIA ILNSGVDMVV GTPGRLEDLI QGGYLSLTHC
RFFVLDEADG LLKQGCTELI DRLHKQIPKI TSDGKRLQMI VCSATLHAFE VKKMAERLMH
FPTWVDLKGE DAVPETVHHV VVTVDPQKDK SWHNLRSHIE TDGVHVRDNV RPGNSTAETL
SEAVKILKGE YCIRAIKEHK MDRALIFCRT KLDCDNLERF LRQSGSQQLS CVCLHGDRKP
AERKANLEKF KRQEVKFLIC TDVAARGLDI TGLPFMINVT LPDEKSNYVH RIGRVGRAER
MGLAISLVSS VPEKVWYHGE WCSSRGRNCQ NTNLTNQGGC CTWYNEPNYL AEIEDHLNVT
IQQVGMDIKV PLNEFDGKVT YGEKRMAMGS NYENHVQQMA PIVAELAALE SRAQLAFLKK
HVVER
//
