ID   E2BWU5_HARSA            Unreviewed;       756 AA.
AC   E2BWU5;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   SubName: Full=Biotin--protein ligase {ECO:0000313|EMBL:EFN79809.1};
GN   ORFNames=EAI_11015 {ECO:0000313|EMBL:EFN79809.1};
OS   Harpegnathos saltator (Jerdon's jumping ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX   NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN   [1] {ECO:0000313|EMBL:EFN79809.1, ECO:0000313|Proteomes:UP000008237}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN79809.1,
RC   ECO:0000313|Proteomes:UP000008237};
RX   PubMed=20798317; DOI=10.1126/science.1192428;
RA   Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA   Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA   Wang J., Liebig J.;
RT   "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT   saltator.";
RL   Science 329:1068-1071(2010).
CC   -!- SIMILARITY: Belongs to the biotin--protein ligase family.
CC       {ECO:0000256|ARBA:ARBA00009934}.
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DR   EMBL; GL451188; EFN79809.1; -; Genomic_DNA.
DR   AlphaFoldDB; E2BWU5; -.
DR   STRING; 610380.E2BWU5; -.
DR   EnsemblMetazoa; XM_025304824.1; XP_025160609.1; LOC105187433.
DR   InParanoid; E2BWU5; -.
DR   OMA; VEHCPLH; -.
DR   Proteomes; UP000008237; Unassembled WGS sequence.
DR   GO; GO:0004077; F:biotin-[acetyl-CoA-carboxylase] ligase activity; IEA:InterPro.
DR   GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR   InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR   InterPro; IPR004408; Biotin_CoA_COase_ligase.
DR   InterPro; IPR003142; BPL_C.
DR   InterPro; IPR004143; BPL_LPL_catalytic.
DR   NCBIfam; TIGR00121; birA_ligase; 1.
DR   PANTHER; PTHR12835; BIOTIN PROTEIN LIGASE; 1.
DR   PANTHER; PTHR12835:SF5; BIOTIN--PROTEIN LIGASE; 1.
DR   Pfam; PF02237; BPL_C; 1.
DR   Pfam; PF03099; BPL_LplA_LipB; 1.
DR   SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR   PROSITE; PS51733; BPL_LPL_CATALYTIC; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:EFN79809.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008237}.
FT   DOMAIN          493..681
FT                   /note="BPL/LPL catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51733"
SQ   SEQUENCE   756 AA;  85493 MW;  E09398E2616104AF CRC64;
     MQIDWDIYVE KLMALSTAAQ EASKEQKPQK IADYIIYPQN QETDAKITLS ATSIDSIKEL
     MDDTGNETLS ETSQASHLKS AADNIKEHNL EPPVNTSITS KEVHAASSMT KESGDSTIVQ
     SYDITKKKDN ILSSTNNEIS MKDMYQSKST VVTKNFKAPF TLKEDKKSSK MVKPPNVVVY
     ADSPDAINNV KTILEKVLDP DRYIIYVLSR ETACSNVWID QVALVVICGN VDSEIKTQLV
     EYVIHGGKLL ALCSDMLHTL LPSFKTAEVR ESELVHFSYG KWKHMRMMHH IFCYHASPVR
     ARFSQDQEDT RTPGLNPPAS TSVKDKRGNL HSFNVKVLGT EETWHNPSIL LATLASSGGK
     VVFSQIHLEV DPTQYEYEED KFKALKESNA ARLEIISDLL STHLEMEIRS HAKAVATYTP
     AYFLGRYEEK IEVLKKLKSK MQPYDLLKMS QLSIQFCSKY NELQRIAPSA SCLPILIHGC
     PDNFSTTKYF ERLDTKKLGR LVIYADVLTS SMHVTDCTLL EHGLAVIPRQ QTKGEGRSQN
     IWLSPIGCAM FTLQMHFNVN SVIGSHISIL QHYIAVAMVH TIRSKPGYEN IDLRLKWPND
     IYVGNSTKIG GLLIKTKIDG TNCICDIGTG INLFNSKPTL CINNIIEDYN QKHGTNLQTI
     SYEEFIAEIF NCIEYLIDKT IYPEDTKFFY ELYYKYWLHE NSNVTVVKRN GESENVTIKG
     IDDFGYLLVE DDKGNKFFLH PDGNTFDLLK GLIIPK
//