ID E2BZ84_HARSA Unreviewed; 1711 AA.
AC E2BZ84;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 08-NOV-2023, entry version 48.
DE SubName: Full=Tuberin {ECO:0000313|EMBL:EFN78990.1};
GN ORFNames=EAI_12143 {ECO:0000313|EMBL:EFN78990.1};
OS Harpegnathos saltator (Jerdon's jumping ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN [1] {ECO:0000313|EMBL:EFN78990.1, ECO:0000313|Proteomes:UP000008237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN78990.1,
RC ECO:0000313|Proteomes:UP000008237};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
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DR EMBL; GL451577; EFN78990.1; -; Genomic_DNA.
DR STRING; 610380.E2BZ84; -.
DR InParanoid; E2BZ84; -.
DR OMA; CDIMSAI; -.
DR Proteomes; UP000008237; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0033596; C:TSC1-TSC2 complex; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR003913; Tuberin.
DR InterPro; IPR018515; Tuberin-type_domain.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR InterPro; IPR024584; Tuberin_N.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR PANTHER; PTHR10063:SF0; TUBERIN; 1.
DR Pfam; PF11864; DUF3384; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF03542; Tuberin; 1.
DR PRINTS; PR01431; TUBERIN.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000008237}.
FT DOMAIN 1454..1681
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 821..845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 959..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1098..1194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1252..1305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1344..1381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1395..1416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 978..996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1115..1144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1161..1181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1254..1305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1356..1370
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1397..1411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1711 AA; 193087 MW; FA801E232CA4BF7F CRC64;
MVVKEYDVPE DIGPRLELLQ TLTEHGKDIL HLEERMGPFL LEWMPTVTAG DGKRGAEFLS
LLVNVIKFNS AYIDEDIVSG LVQYISHLCY YSNSTEVVSG CLEALDAIMC YSNLQSDSLQ
TFVIALCRSV NVETYCQTSW KIMRNLLGTH MGHCALYTMC RLLQDVNFQR DVRLLRGAVF
YVNMGLWGTH RIPKLECTPA SVLPSFYQAL QCNHPIVMYE VTLSIQRLVN KYGNELWDPT
WSIILDIVEE VIAHTETSNQ PATKQVSTSL HETITNIENL LDTNNYNGCI QRFYDLVERC
SDTRPEGSVL KLIEYRTCTI SPTYYQWQAK LGSLVERYYK IETRTTIRMK VLDVLINVIQ
VNRFRYEDEL IERIVVPYTQ HVDVDPDITI RNATANLLVD LCLECDTKLC LELLDILEKI
INKPFTSDTP VSTDADVKDV KTAIVGIIKI FTSKIYRLPS SHAICAYKIL VNHLEQHYKD
PSVFHDVSTI RYLIFESFLK IRANSLYHLG ILDVSNGVVM RFSPYLVLEH STTERINNAS
GGNSPPPASP APLQHLSCHV TPMSLTHAWK AVISCIKQEK DWKVLHLILK ELPQVMQNRA
LMLSRHSNDI DIFAAALCSM VSDKSLRLPE SLYNVPPKFT LSEFRVYVFP VLASLSSYHA
HLEPNLQQRL IKCLEVGLTA KCASQCVTSL TICTLEMRDA MNKLLTEVLL NLSKISATVY
IAIPILEFLS TLTRLPKVFA SFIGDQYMSV FAILLPYTNP FKYNHYTVSL AHHVIAVWFL
KCRLSFRRDF VKFIITGLNT NVIVPFEEGH LMKSDFSAIN EDSSNRKRSS SLTEQGSRGR
RERPIMSNRM IGESRALDLK PPIDEALMKF HIELTETCID LMARYTFSNF SARPKRLPAA
DFLLKEGQSM TWILGNRLIT VTTSGCSNKA MRGGLCDNCW IACKPGFLLL DQTKTSQSNL
QRTSSLETSK EDKLSRQSSG GHGSSNANTA ANSPTEESKK STEDSDNIKK DFLTEVTKID
KDQVEQSKLG QILNSNKQDG HVLCACWCQG WAEIYVRRPT GDMSWIMRIQ NSTQFETPMD
FPVHDIMALY MPNQDAVANK QQETATEFSG DETEDVPNKI NNQSLIEYNV KSTMSSSTSS
GPIAIPGSPV RPSPSRQSSR DSLESLEEGE EDTRRSRNPV RRSNSSPEMS ANWKNPFLNK
EKLNMQQQAD KDLASSDLEV KLDAELKKHS KNIYTKDMRV SCEAIPEEIF GMGTTPPSSE
NIGDHPTALR SQRSYPGATQ ISQTLSSTTS STVPPSPTTV QAPESYLGIQ TRSTQVQSSG
IIKAPQSPTQ IYSRLSNLDY NQKQVPLTVE SKPPIGRSHF SDKKDERPDP STLPPLPISF
RDRGHTISVM SPVKKSRGEW DNMRRGNSPR VKDPPRTGIN PSFVFLQLYH AAHFGITTEK
PLLVPQTTAI QRVVTNLDRI QPYETHKIGV LYVGPGQASN ETEILANQHG SLRYTEFLKR
LGTLVRLKDV DENVFLGGLD RNGENGDFAY IWQDDVTQVA FHVATLMPTK VSDPKCTSKK
THIGNNYVTL VYNESDEPYN IQTVKGQFNY ACVVIQPLDH GTNQLTVQAR EELAEHIGHS
EPKIISDQNL AILSRQLALH ANLASMVCSS LKQNSHNPYA SNWLERLRHI KRLRNRVLKE
TVNNNPDTTT DELSPRANKR VYMDDFTEYT T
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