ID E2C7R2_HARSA Unreviewed; 2285 AA.
AC E2C7R2;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Laminin subunit alpha-1 {ECO:0000313|EMBL:EFN76045.1};
GN ORFNames=EAI_16148 {ECO:0000313|EMBL:EFN76045.1};
OS Harpegnathos saltator (Jerdon's jumping ant).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN [1] {ECO:0000313|EMBL:EFN76045.1, ECO:0000313|Proteomes:UP000008237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN76045.1,
RC ECO:0000313|Proteomes:UP000008237};
RX PubMed=20798317; DOI=10.1126/science.1192428;
RA Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA Wang J., Liebig J.;
RT "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT saltator.";
RL Science 329:1068-1071(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR EMBL; GL453395; EFN76045.1; -; Genomic_DNA.
DR STRING; 610380.E2C7R2; -.
DR EnsemblMetazoa; XM_025303814.1; XP_025159599.1; LOC105190900.
DR InParanoid; E2C7R2; -.
DR OMA; TVRQHVH; -.
DR Proteomes; UP000008237; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00055; EGF_Lam; 8.
DR CDD; cd00110; LamG; 5.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009254; Laminin_aI.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF273; BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 1.
DR Pfam; PF00053; Laminin_EGF; 8.
DR Pfam; PF00054; Laminin_G_1; 2.
DR Pfam; PF02210; Laminin_G_2; 3.
DR Pfam; PF06008; Laminin_I; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00180; EGF_Lam; 8.
DR SMART; SM00281; LamB; 1.
DR SMART; SM00282; LamG; 5.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01248; EGF_LAM_1; 4.
DR PROSITE; PS50027; EGF_LAM_2; 7.
DR PROSITE; PS50025; LAM_G_DOMAIN; 5.
DR PROSITE; PS51115; LAMININ_IVA; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000008237};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 62..110
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 111..158
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 206..249
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 250..304
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 336..537
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 580..626
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 627..681
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 682..729
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1300..1492
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1502..1688
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1693..1913
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1925..2097
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2102..2282
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT COILED 828..862
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1273..1300
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 62..74
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 64..81
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 83..92
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 111..123
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 113..130
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 132..141
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 225..234
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 275..284
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 599..608
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 652..661
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 682..694
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 684..701
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 703..712
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 2255..2282
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 2285 AA; 254305 MW; 35F0B68AD1D76922 CRC64;
MPHELLMEPP STLVGASRLQ AASLNYVVCS AEVNSHRGES IRVRNLRVRE DTQRHIHTIA
GCGCSSFGST SSACDIVSGQ CQCKPQVVGR QCNECKIGYW GLASGTGCAT CNCDTMGSRN
VSCHSNTGQC YCKPGVGGSR CDTCLSGHYG FSANGCQLCD PCVRPGHMCD PDTGRCVCPS
LTYGEHCDRC RPGAWDLVPR VGCRPCACTL GATRPQCDHQ GQCPCRIGYD GLRCERCAKG
YYGYPRCRPC SCNAAGTTQC QDGICGCDDK GQCPCKELAV GRQCDQCKEG TFGLAADNAR
GCTECFCFRR SALCRQARLS WGQRRLTHPR ALYTNGTDHD ITITDFGATT VLPTVNGGLN
VTNGLTVIPG SDGDVTLPSN LYYNYPLYWR LPDSFLGDKV VSYGGFLRFK VSTEDGIPVR
SNLRYPLVQM QGNNKIVLEY YLRVPVSDDR YEIRFHESLW QLRNRPDYKV SREVLMVALQ
NLQYILIKAS DNSDFPRTTK ASSPLNLGIS FKLLEASLDA AVLTPTHSPS LAIGVEICEC
PPEYNGTSCQ DPSIGYYRWH ANTTAVSTGV VDFVGQARRC QCNGRSDVCD RETGYCLDCR
EYTIGAHCDV CMDSFYGHPE FGGCRPCPCP QVDKRFSSTC VIRMGIEPIC HCKPGYTGRK
CERCSYGYYG LPDLPDGKCV PCNCNLAGSV SDACDGETGQ CKCRPGSTGR DCSECTAYRH
VYINDVCTTC DDNCTGILLN TVEMMSARLA ADTNDIADGY ILPPWEALTH IDSNATEYLG
EVELRDRLRQ RMRNVPWHKY RKLAEEVEAM LRNTNTYAKH ADTLKTRSSD LKNNIFSAKI
EVEKLRRKIE DTILQLNQYS NDNRRIGIKK ALKTGKMILS YLKSVDISKR TMEVEDFLDE
VAKYVAWLNL LEDVTEPLAA IQDDTEDYTV KLNDITTVVE DTMETLFTYD GLYNGINKTF
IDTKEQCARI GTLRGETNKT IVEGQNLVDE ARGFLVDAEN DIQDLPGLQD KLAHWKEKLT
MREEILYRLN YEYNQQYVVP AIKHAKNLSS YADQYVSLFA ETRDIAASPL KASQAYKNIV
DSLQMARTTA LAAKAAAEEA HEKVFPPSGQ RSLLDEAKEA FSKSSQQWET AKEHDKLVKN
ANAELETQKH AVYTLKDTLN NTGIKDNQIN VKLRELQGSS KKFHEDLQNI LDENDKVKES
MKNTQRLIDD YNQGIADRLK PKLNELKREG DSKISLASEK LTEALSNIKK ADAKLISLSN
AAMKRKAVFD KWNDTLATKL QNLKDKIAEA RNTVDGIRVS VKSVDGKQCI RSYRPETLQP
SATTSIVMTF VLPAGRKEGS LFYLPSGIND DFVALEIVDR KVRFLWNVGG GTGILTHPEV
LENGDLQNDM SWYRVEAERT RHIGKLSVRK QTSTSGRYLP VINSTNSEYG RFDVLPTDRV
WIGGIPKSQR KPMELIAPNG LPGCVHQVIL DGKQIGLWNF ISTAPDMACT ACVEGVVDAR
DDIAYSFNGK GYAVRNRVSS VPYIWSLFGV SFSFRTYDEN ALLFLAINPD NNQHIMIYLR
EGKVILHVGY GGNVSMEMSS TYKYNTGNWT KMDAWRQYLV QKNIEKCSLS IDTDDDKRIG
APTPQPKKED IPNLARAKYY IGGLPPSFRA DDVVLPSQVS FLGCMSNIVV QDGYDPMAEL
YYGVEPSCRN KPLTVVGFYG DGYLEHPAST LKKKHSVLSF SFRTVQEAAM LLLSTSEGSE
VGSSSGTDDM NQEQNNKNYY SVCIVNGQVQ ARLNAGRGEL LLQSNGTFND GRYHSATVIK
TRKEIELRID DAYQSTGRLP TSAAIKAPNV NGGLFFGGLP ALINNTKMVT THTPLYGAIK
DVIINDQIIR FDDAVNFDHA LIGRSGPSMG KDPPTYVPSA SLSRGMSTQP EGCQKVPYYS
LEPGALKFGD KPHSHTQLYL NFKKFWEKKY MIEFDFRTYY PNGLLFITPG LRLKNHLMVI
IQDGQLLLSL KGKQQRQMLF KTPFNDGNWH HVVLSHDDRK LTLLVDTQTP RILKVPRRAG
LTSMMYIGGL PESGTPFPDN VISKLETLKG CIRGLRVNGN VYDMVGSTSR AFNVGQCFPS
VESGAYFQDE AYAIYQKNFE LGAVLELQLE FRTSELSGVL LSISAPDGSP SLALELNNGR
VIMSGDLGDN NPLYVEQRFA SPYAICDNRW HRIQAVYNDE ELALKVDELD QKYGLPTKAN
YHFADSTAYG PLYIGGIPAS AQKGSLVTRD HFNGCIRNVM IGGERRDWTD MDELHNIHLS
SCPVQ
//
