ID   E2CA48_HARSA            Unreviewed;       336 AA.
AC   E2CA48;
DT   30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2010, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   SubName: Full=Interferon-inducible double stranded RNA-dependent protein kinase activator A {ECO:0000313|EMBL:EFN75203.1};
GN   ORFNames=EAI_08868 {ECO:0000313|EMBL:EFN75203.1};
OS   Harpegnathos saltator (Jerdon's jumping ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Ponerinae; Ponerini; Harpegnathos.
OX   NCBI_TaxID=610380 {ECO:0000313|Proteomes:UP000008237};
RN   [1] {ECO:0000313|EMBL:EFN75203.1, ECO:0000313|Proteomes:UP000008237}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R22 G/1 {ECO:0000313|EMBL:EFN75203.1,
RC   ECO:0000313|Proteomes:UP000008237};
RX   PubMed=20798317; DOI=10.1126/science.1192428;
RA   Bonasio R., Zhang G., Ye C., Mutti N.S., Fang X., Qin N., Donahue G.,
RA   Yang P., Li Q., Li C., Zhang P., Huang Z., Berger S.L., Reinberg D.,
RA   Wang J., Liebig J.;
RT   "Genomic comparison of the ants Camponotus floridanus and Harpegnathos
RT   saltator.";
RL   Science 329:1068-1071(2010).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GL453920; EFN75203.1; -; Genomic_DNA.
DR   RefSeq; XP_011153401.1; XM_011155099.2.
DR   RefSeq; XP_019700843.1; XM_019845284.1.
DR   AlphaFoldDB; E2CA48; -.
DR   STRING; 610380.E2CA48; -.
DR   EnsemblMetazoa; XM_011155099.3; XP_011153401.1; LOC105191584.
DR   EnsemblMetazoa; XM_025299021.1; XP_025154806.1; LOC105191584.
DR   GeneID; 105191584; -.
DR   KEGG; hst:105191584; -.
DR   InParanoid; E2CA48; -.
DR   OMA; QEMMVKQ; -.
DR   OrthoDB; 3676715at2759; -.
DR   PhylomeDB; E2CA48; -.
DR   Proteomes; UP000008237; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:UniProt.
DR   CDD; cd19862; DSRM_PRKRA-like_rpt1; 1.
DR   Gene3D; 3.30.160.20; -; 2.
DR   InterPro; IPR014720; dsRBD_dom.
DR   PANTHER; PTHR46205; LOQUACIOUS, ISOFORM B; 1.
DR   PANTHER; PTHR46205:SF3; LOQUACIOUS, ISOFORM B; 1.
DR   Pfam; PF00035; dsrm; 2.
DR   SMART; SM00358; DSRM; 2.
DR   SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR   PROSITE; PS50137; DS_RBD; 2.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:EFN75203.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008237};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266};
KW   Transferase {ECO:0000313|EMBL:EFN75203.1}.
FT   DOMAIN          4..71
FT                   /note="DRBM"
FT                   /evidence="ECO:0000259|PROSITE:PS50137"
FT   DOMAIN          109..177
FT                   /note="DRBM"
FT                   /evidence="ECO:0000259|PROSITE:PS50137"
SQ   SEQUENCE   336 AA;  37296 MW;  718B5DA30A877397 CRC64;
     MNKTPVSILQ EMMVKKGSVP NYELIHDGGG THINTFTYKV TCDGFTATGT GRCKKDAKHE
     AANAMLTTIA THRNYPQLPA SPATSPVRTP MPDSLPMSPR MPANIPFVNT IGALQDLCAE
     NNLQEPEYVP VSDVGPPHAR VFTIRCVVSN FSEDGVGTTK KQAKHDAAKK MVDKINSLVN
     GKLKSLSIEN DPENNKDFEL SSEFAKSKYC ILKKLTRKTN LGIRLTEYHT VTRDNLDTDL
     RHKILEELCN LIPSDFSQVT DELLLEKLSK LGNLLSEVNI ALILQDARFI DTRNYTKIMQ
     LDTCPPIIQI GIGKTEAEAT FKALSYMIST LKLLWS
//