ID E2PT15_ASPNC Unreviewed; 366 AA.
AC E2PT15;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Contig An18c0040, genomic contig {ECO:0000313|EMBL:CAK47187.1};
DE EC=1.1.1.- {ECO:0000313|EMBL:CAK47187.1};
GN ORFNames=An18g01100 {ECO:0000313|EMBL:CAK47187.1};
OS Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=425011 {ECO:0000313|EMBL:CAK47187.1, ECO:0000313|Proteomes:UP000006706};
RN [1] {ECO:0000313|EMBL:CAK47187.1, ECO:0000313|Proteomes:UP000006706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892
RC {ECO:0000313|Proteomes:UP000006706};
RX PubMed=17259976; DOI=10.1038/nbt1282;
RA Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X.,
RA Contreras R., Cornell M., Coutinho P.M., Danchin E.G., Debets A.J.,
RA Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J.,
RA d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W.,
RA Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.,
RA van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M.,
RA Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J.,
RA Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U.,
RA Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J.,
RA Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA van Ooyen A.J., Visser J., Stam H.;
RT "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT niger CBS 513.88.";
RL Nat. Biotechnol. 25:221-231(2007).
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DR EMBL; AM270397; CAK47187.1; -; Genomic_DNA.
DR RefSeq; XP_001398574.2; XM_001398537.2.
DR AlphaFoldDB; E2PT15; -.
DR EnsemblFungi; CAK47187; CAK47187; An18g01100.
DR GeneID; 4989670; -.
DR VEuPathDB; FungiDB:An18g01100; -.
DR HOGENOM; CLU_026673_3_4_1; -.
DR Proteomes; UP000006706; Chromosome 8L.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd08276; MDR7; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR45033; -; 1.
DR PANTHER; PTHR45033:SF2; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:CAK47187.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006706}.
FT DOMAIN 18..342
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 366 AA; 39580 MW; DE1277EDCA52A053 CRC64;
MSHAQITHRR AVRRTDDYTP HTPKVNIVTE PLPLPLSPTA VLIRVHAVAL NYRDANIANG
GNPWPVLPHG ILGNDAAGEV IAVGEKVKTL AVGDRAAPIT DTEQITERAT KRSWLAADED
GVMADYIVYD ESVLCKLPAY LDWVQASMIP CAGVTAWSAL KGMRIGQTVL VQGTGGVSMF
ALKLALAAGL RVVLTSSSDA KLQAIKEKYA GSAILTVNYK NTPEWDEEVL KLTGGVGVDL
VVENGGTGSL VKSMRCTRRG GVVSQVGYLG KQDPSELSEL VPTLIDRRIN LRGINAGSKL
DMEDFCEALS ASQTLLDDLI DKVFPFEQAE EAVEYVWQEK DIGSERKIQN SFYHLGSYVG
TWSSAS
//
