ID E2RSF2_CANLF Unreviewed; 222 AA.
AC E2RSF2;
DT 30-NOV-2010, integrated into UniProtKB/TrEMBL.
DT 30-NOV-2010, sequence version 1.
DT 16-JAN-2019, entry version 63.
DE RecName: Full=Superoxide dismutase {ECO:0000256|RuleBase:RU000414};
DE EC=1.15.1.1 {ECO:0000256|RuleBase:RU000414};
GN Name=SOD2 {ECO:0000313|Ensembl:ENSCAFP00000000951,
GN ECO:0000313|VGNC:VGNC:53988};
GN Synonyms=sod2 {ECO:0000313|EMBL:AXQ04899.1};
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
OC Canis.
OX NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000000951, ECO:0000313|Proteomes:UP000002254};
RN [1] {ECO:0000313|Ensembl:ENSCAFP00000000951, ECO:0000313|Proteomes:UP000002254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000000951,
RC ECO:0000313|Proteomes:UP000002254};
RX PubMed=16341006; DOI=10.1038/nature04338;
RG Broad Sequencing Platform;
RA Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
RA Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C.,
RA Mauceli E., Xie X., Breen M., Wayne R.K., Ostrander E.A.,
RA Ponting C.P., Galibert F., Smith D.R., deJong P.J., Kirkness E.F.,
RA Alvarez P., Biagi T., Brockman W., Butler J., Chin C.-W., Cook A.,
RA Cuff J., Daly M.J., DeCaprio D., Gnerre S., Grabherr M., Kellis M.,
RA Kleber M., Bardeleben C., Goodstadt L., Heger A., Hitte C., Kim L.,
RA Koepfli K.-P., Parker H.G., Pollinger J.P., Searle S.M.J.,
RA Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
RA Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
RA Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L.,
RA Bachantsang P., Barry A., Bayul T., Benamara M., Berlin A.,
RA Bessette D., Blitshteyn B., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Brown A., Cahill P., Calixte N.,
RA Camarata J., Cheshatsang Y., Chu J., Citroen M., Collymore A.,
RA Cooke P., Dawoe T., Daza R., Decktor K., DeGray S., Dhargay N.,
RA Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L., Duffey N.,
RA Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
RA Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K.,
RA Foley C., Franke A., Friedrich D., Gage D., Garber M., Gearin G.,
RA Giannoukos G., Goode T., Goyette A., Graham J., Grandbois E.,
RA Gyaltsen K., Hafez N., Hagopian D., Hagos B., Hall J., Healy C.,
RA Hegarty R., Honan T., Horn A., Houde N., Hughes L., Hunnicutt L.,
RA Husby M., Jester B., Jones C., Kamat A., Kanga B., Kells C.,
RA Khazanovich D., Kieu A.C., Kisner P., Kumar M., Lance K., Landers T.,
RA Lara M., Lee W., Leger J.-P., Lennon N., Leuper L., LeVine S., Liu J.,
RA Liu X., Lokyitsang Y., Lokyitsang T., Lui A., Macdonald J., Major J.,
RA Marabella R., Maru K., Matthews C., McDonough S., Mehta T.,
RA Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T., Miller K.,
RA Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A., Naylor J.,
RA Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
RA Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K.,
RA Osman S., Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F.,
RA Priest M., Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C.,
RA Rege F., Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S.,
RA Sharpe T., Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J.,
RA Smith C., Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S.,
RA Stone C., Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S.,
RA Thoulutsang D., Thoulutsang Y., Topham K., Topping I., Tsamla T.,
RA Vassiliev H., Venkataraman V., Vo A., Wangchuk T., Wangdi T.,
RA Weiand M., Wilkinson J., Wilson A., Yadav S., Yang S., Yang X.,
RA Young G., Yu Q., Zainoun J., Zembek L., Zimmer A., Lander E.S.;
RT "Genome sequence, comparative analysis and haplotype structure of the
RT domestic dog.";
RL Nature 438:803-819(2005).
RN [2] {ECO:0000313|Ensembl:ENSCAFP00000000951}
RP IDENTIFICATION.
RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000000951};
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [3] {ECO:0000313|EMBL:AXQ04899.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Canine mammary cancer tissue {ECO:0000313|EMBL:AXQ04899.1};
RA Arora R., Saxena S., Shrivastava S., Hussain S., Kumar N.;
RT "Genetic Characterization and Expression Analysis of Recombinant
RT Manganese Superoxide Dismutase (MnSOD) from Spontaneously Occurring
RT Canine Mammary Tumor.";
RL Adv Anim Vet Sci 1:363-369(2016).
RN [4] {ECO:0000313|EMBL:AXQ04899.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Canine mammary cancer tissue {ECO:0000313|EMBL:AXQ04899.1};
RA Ehlers B., Leendertz F.H.;
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Destroys radicals which are normally produced within the
CC cells and which are toxic to biological systems.
CC {ECO:0000256|RuleBase:RU000414}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC ChEBI:CHEBI:18421; EC=1.15.1.1;
CC Evidence={ECO:0000256|RuleBase:RU000414};
CC -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase
CC family. {ECO:0000256|RuleBase:RU000414}.
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DR EMBL; AAEX03000317; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; MG010808; AXQ04899.1; -; mRNA.
DR RefSeq; XP_533463.3; XM_533463.5.
DR STRING; 9615.ENSCAFP00000000951; -.
DR PaxDb; E2RSF2; -.
DR PRIDE; E2RSF2; -.
DR Ensembl; ENSCAFT00000001037; ENSCAFP00000000951; ENSCAFG00000000671.
DR GeneID; 476258; -.
DR KEGG; cfa:476258; -.
DR CTD; 6648; -.
DR VGNC; VGNC:53988; SOD2.
DR eggNOG; KOG0876; Eukaryota.
DR eggNOG; COG0605; LUCA.
DR GeneTree; ENSGT00390000011877; -.
DR KO; K04564; -.
DR OMA; YEGWKGE; -.
DR OrthoDB; 1353361at2759; -.
DR TreeFam; TF105132; -.
DR Reactome; R-CFA-2151201; Transcriptional activation of mitochondrial biogenesis.
DR Reactome; R-CFA-3299685; Detoxification of Reactive Oxygen Species.
DR Proteomes; UP000002254; Chromosome 1.
DR Bgee; ENSCAFG00000000671; Expressed in 3 organ(s), highest expression level in adult mammalian kidney.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IBA:GO_Central.
DR GO; GO:0004784; F:superoxide dismutase activity; IBA:GO_Central.
DR GO; GO:0007568; P:aging; IBA:GO_Central.
DR Gene3D; 1.10.287.990; -; 1.
DR Gene3D; 2.40.500.20; -; 1.
DR InterPro; IPR001189; Mn/Fe_SOD.
DR InterPro; IPR019833; Mn/Fe_SOD_BS.
DR InterPro; IPR019832; Mn/Fe_SOD_C.
DR InterPro; IPR019831; Mn/Fe_SOD_N.
DR InterPro; IPR036324; Mn/Fe_SOD_N_sf.
DR InterPro; IPR036314; SOD_C_sf.
DR Pfam; PF02777; Sod_Fe_C; 1.
DR Pfam; PF00081; Sod_Fe_N; 1.
DR PIRSF; PIRSF000349; SODismutase; 1.
DR PRINTS; PR01703; MNSODISMTASE.
DR SUPFAM; SSF46609; SSF46609; 1.
DR SUPFAM; SSF54719; SSF54719; 1.
DR PROSITE; PS00088; SOD_MN; 1.
PE 2: Evidence at transcript level;
KW Complete proteome {ECO:0000313|Proteomes:UP000002254};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000349-1,
KW ECO:0000256|RuleBase:RU000414};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000414,
KW ECO:0000313|EMBL:AXQ04899.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002254}.
FT DOMAIN 25 106 Sod_Fe_N. {ECO:0000259|Pfam:PF00081}.
FT DOMAIN 113 216 Sod_Fe_C. {ECO:0000259|Pfam:PF02777}.
FT METAL 50 50 Divalent metal cation.
FT {ECO:0000256|PIRSR:PIRSR000349-1}.
FT METAL 98 98 Divalent metal cation.
FT {ECO:0000256|PIRSR:PIRSR000349-1}.
FT METAL 183 183 Divalent metal cation.
FT {ECO:0000256|PIRSR:PIRSR000349-1}.
FT METAL 187 187 Divalent metal cation.
FT {ECO:0000256|PIRSR:PIRSR000349-1}.
SQ SEQUENCE 222 AA; 24845 MW; F57E4BD7B8365999 CRC64;
MLSRAALSTS RTLVPALGCL GSRQKHSLPD LPYDYGALEP HINAQIMQLH HSKHHAAYVN
NLNTIEEKYL EALEKGDITA QIALQPGLKF NGGGHINHSI FWTNLSPKGG GEPKGELLEA
IKRDFGSFDK FKEKLTTVSV GVQGSGWGWL GFNKEQGRLQ IAACFNQDPL QGTTGLIPLL
GIDVWEHAYY LQYKNVRPDY LKAIWNVINW ENVTERYMAC KK
//
