ID   E2SL50_9FIRM            Unreviewed;       739 AA.
AC   E2SL50;
DT   11-JAN-2011, integrated into UniProtKB/TrEMBL.
DT   11-JAN-2011, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=Diguanylate cyclase (GGDEF) domain protein {ECO:0000313|EMBL:EFP61949.1};
GN   ORFNames=HMPREF0983_01805 {ECO:0000313|EMBL:EFP61949.1};
OS   Erysipelotrichaceae bacterium 3_1_53.
OC   Bacteria; Bacillota; Erysipelotrichia; Erysipelotrichales;
OC   Erysipelotrichaceae.
OX   NCBI_TaxID=658659 {ECO:0000313|EMBL:EFP61949.1, ECO:0000313|Proteomes:UP000006223};
RN   [1] {ECO:0000313|EMBL:EFP61949.1, ECO:0000313|Proteomes:UP000006223}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3_1_53 {ECO:0000313|EMBL:EFP61949.1,
RC   ECO:0000313|Proteomes:UP000006223};
RG   The Broad Institute Genome Sequencing Platform;
RA   Ward D., Earl A., Feldgarden M., Young S.K., Pearson M., Zeng Q.,
RA   Alvarado L., Berlin A., Bochicchio J., Chapman S.B., Chen Z., Freedman E.,
RA   Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA   Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Roberts A.,
RA   Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T.,
RA   Walk T., White J., Yandava C., Allen-Vercoe E., Strauss J., Sibley C.,
RA   Daigneault M., Haas B., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Erysipelotrichaceae bacterium strain 3_1_53.";
RL   Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EFP61949.1}.
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DR   EMBL; ACTJ01000036; EFP61949.1; -; Genomic_DNA.
DR   AlphaFoldDB; E2SL50; -.
DR   STRING; 658659.HMPREF0983_01805; -.
DR   eggNOG; COG5001; Bacteria.
DR   HOGENOM; CLU_000445_36_1_9; -.
DR   BioCyc; EBAC658659-HMP:GMFE-1832-MONOMER; -.
DR   Proteomes; UP000006223; Unassembled WGS sequence.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 2.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013655; PAS_fold_3.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 2.
DR   PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   PANTHER; PTHR33121:SF71; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 2.
DR   Pfam; PF08447; PAS_3; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 2.
DR   SMART; SM00086; PAC; 1.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 2.
PE   4: Predicted;
FT   DOMAIN          49..183
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          346..479
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          488..739
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
SQ   SEQUENCE   739 AA;  85246 MW;  A2AF0E346FE731C4 CRC64;
     MVTSMRKISV SQDTSFADSG RDHLTGLWNK EEGERLLAAC ICENRKKETA FLTALLDIND
     LSIINKACGH QEGDRVLQKT AKKICAYLNA EDFAIRLGGD EFLIVYQSLS KKEASQQLFQ
     ILRELEQESK AFSYTIGFCF GLIQIDPDTE LSLKKIIMQA DDEMYLSKRR YHMEKSRAAF
     FSRPYHESQE VRQFTYDKEL LLSALMQSTD DYIYVCNMKE DPSCFRYSPA MVEEFDLPSE
     IIHDAANVWG ARIHEADQTV FLEGNQEIAD GRVDRHNVEY RAKNRNGEWV WLRCRGYVER
     DEDGKPALFA GIITNLGRKN KIDYLTGQFN KYELEDTLQM MIAKQEQFFM IMLDLDEFSS
     INKLYNHQFG DEVLAKTAQL IQSVLPENAR LYRNDGDEFI VLIRNSTDKE EIMTFYQHLQ
     QELSHQRVLD GKKYHCSVSA GCAAFPRDAN DMMTLTKNVG YALEISKRNG KNRLTLYEKE
     MSETELQELD MIEQLRYSIE HDFEGFQLHY QPQVEANSGR IIGAEALARW SSSMYGNVPP
     MTFIPLLEKS GMIVPAGKWI FETAVQQCAL WLKKHPDFCV SVNLSYLQLC DEGFPSFMKH
     VLHHYQVPSG NIVVEMTESY MVKSGEELRL IFHEIREIGI RIAMDDFGTG YSSLGVLKNS
     PADIVKIDRI FMKDILTSEF DATFIRFVVR LCHDVNIRVL LEGVETQEEY DKVKTMGLDY
     IQGYFFGRPM TLEAFESSL
//